Poly(1-vinylpyrrolidone-co-vinyl acetate)
- Product Name
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
- CAS No.
- 25086-89-9
- Chemical Name
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
- Synonyms
- VP/VA COPOLYMER;pvp-va;e335;kollidonva64;i735;i635;i535;e535;s630;kolima75
- CBNumber
- CB9295023
- Molecular Formula
- C10H15NO3
- Formula Weight
- 197.23
- MOL File
- 25086-89-9.mol
Poly(1-vinylpyrrolidone-co-vinyl acetate) Property
- Density
- 1.27 g/mL at 25 °C(lit.)
- refractive index
- 1.4300 to 1.4380
- Flash point:
- 72 °F
- solubility
- Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
- form
- powder
- color
- White
- Stability:
- Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
- InChI
- InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
- InChIKey
- FYUWIEKAVLOHSE-UHFFFAOYSA-N
- SMILES
- C(N1CCCC1=O)=C.O(C=C)C(=O)C
- LogP
- 0.370 (est)
- EPA Substance Registry System
- Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38-67-36-11-22
- Safety Statements
- 22-24/25-36/37/39-26-16
- RIDADR
- UN 1987 3/PG 2
- WGK Germany
- 1
- RTECS
- AH3539000
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29349990
- Toxicity
- LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 190837
- Product name
- Poly(1-vinylpyrrolidone-co-vinyl acetate) solution
- Purity
- average Mw ~13,000 (GPC vs. poly(ethylene oxide)), 50 wt. % in isopropanol
- Packaging
- 500g
- Price
- $126.6
- Updated
- 2024/03/01
- Product number
- 1148500
- Product name
- Poly(1-vinylpyrrolidone-co-vinyl acetate) solution
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $491
- Updated
- 2024/03/01
- Product number
- P0382
- Product name
- Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol)
- Packaging
- 25g
- Price
- $19
- Updated
- 2024/03/01
- Product number
- P0382
- Product name
- Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol)
- Packaging
- 500g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 190845
- Product name
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
- Purity
- average Mw ~50,000 (GPC vs. poly(ethylene oxide)), powder
- Packaging
- 250g
- Price
- $195
- Updated
- 2024/03/01
Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties,Usage,Production
Chemical Properties
white powder
Chemical Properties
Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.
Uses
Poly(1-vinylpyrrolidone-co-vinyl acetate)
Uses
Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.
Production Methods
Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.
General Description
～1:2.4 mole ratio of VP:VA
Pharmaceutical Applications
Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Safety Profile
Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.
Safety
Copovidone is used widely in pharmaceutical formulations and is
generally regarded as nontoxic. However, it is moderately toxic by
ingestion, producing gastric disturbances. It has no irritating or
sensitizing effects on the skin. A study was conducted to look at the
carcinogenicity and chronic toxicity of copovidone (Kollidon VA
64) in Wistar rats and Beagle dogs. The results of these studies
demonstrated the absence of any significant toxicological findings
of high dietary levels of copodivone in rats and dogs, resulting in noobserved-
adverse-effect levels of 2800 mg/kg body-weight/day in
rats and 2500 mg/kg body-weight/day in dogs, the highest doses
tested.
LD50 (rat, oral): >0.63 g/kg
storage
Copovidone is stable and should be stored in a well-closed container in a cool, dry place.
Incompatibilities
Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.
Regulatory Status
Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).
Poly(1-vinylpyrrolidone-co-vinyl acetate) Preparation Products And Raw materials
Raw materials
Preparation Products
Poly(1-vinylpyrrolidone-co-vinyl acetate) Suppliers
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View Lastest Price from Poly(1-vinylpyrrolidone-co-vinyl acetate) manufacturers
- Product
- VP/VA Copolymer 25086-89-9
- Price
- US $25.00-15.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20ton
- Release date
- 2023-10-19
- Product
- Vinylpyrrolidone PVP/VA Copolymer Powder 25086-89-9
- Price
- US $25.00-15.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2023-10-25
- Product
- PVP/VA 25086-89-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-19