FLECAINIDE ACETATE
- Product Name
- FLECAINIDE ACETATE
- CAS No.
- 54143-56-5
- Chemical Name
- FLECAINIDE ACETATE
- Synonyms
- FLAC;Apocard;Tambocor;r-818;Ecrinal;Almarytm;Flucarney Acetate;FLECAINIDE ACETATE;Flecainide-d4 Acetate;Flecainide acetate CRS
- CBNumber
- CB9295801
- Molecular Formula
- C19H24F6N2O5
- Formula Weight
- 474.39
- MOL File
- 54143-56-5.mol
FLECAINIDE ACETATE Property
- Melting point:
- 145-147℃
- storage temp.
- 2-8°C
- solubility
- Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid.
- form
- Solid
- color
- White
- Water Solubility
- Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water.
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-63
- Safety Statements
- 22-26-36/37/39-45-46
- RIDADR
- 3249
- WGK Germany
- -
- RTECS
- CV5792550
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2933399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- F6777
- Product name
- Flecainide acetate salt
- Packaging
- 25mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- PHR2921
- Product name
- Flecainide Acetate
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 500MG
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 1270800
- Product name
- Flecainide acetate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- BP676
- Product name
- Flecainide acetate
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $259
- Updated
- 2023/06/20
- Product number
- J63527
- Product name
- Flecainide acetate, 98%
- Packaging
- 100mg
- Price
- $238
- Updated
- 2024/03/01
FLECAINIDE ACETATE Chemical Properties,Usage,Production
Description
Flecainide acetate (54143-56-5) is an open Na+?channel blocker that inhibits fast Na+?current in cardiac muscle in a use- and concentration-dependent manner.1?Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4
Chemical Properties
White or almost white, very hygroscopic, crystalline powder.
Uses
Class I antiarrhythmic.
Uses
Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias.
Definition
ChEBI: An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
brand name
Tambocor (3M Pharmaceuticals).
General Description
Flecainide acetate, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)benzamide monoacetate(Tambocor), is a class IC antiarrhythmic drug withlocal anesthetic activity; it is a chemical derivative of benzamide.The drug undergoes biotransformation, forming ameta-O-dealkylated compound, whose antiarrhythmic propertiesare half as potent as those of the parent drug, and ameta-O-dealkylated lactam of flecainide with little pharmacologicalactivity. Flecainide acetate is given orally to suppresschronic ventricular ectopy and ventricular tachycardia.It has some limitations because of CNS side effects.
Biological Activity
Open Na + channel blocker that inhibits fast Na + current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.
Biochem/physiol Actions
Class IC antiarrhythmic agent; sodium channel blocker
Drug interactions
Potentially hazardous interactions with other drugs Anti-arrhythmics: concentration increased by amiodarone - halve dose of flecainide; increased myocardial depression with other anti-arrhythmics. Antidepressants: concentration increased by fluoxetine; increased risk of ventricular arrhythmias with tricyclics. Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid. Antihypertensives: increased myocardial depression and bradycardia with beta-blockers; increased myocardial depression and asystole with verapamil. Antimalarials: concentration increased by quinine; avoid with artemether/lumefantrine. Antimuscarinics: increased risk of ventricular arrhythmias with tolterodine. Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval and phenothiazines; increased risk of arrhythmias with clozapine. Antivirals: concentration possibly increased by fosamprenavir, indinavir, lopinavir, ritonavir and saquinavir, increased risk of ventricular arrhythmias - avoid; use telaprevir with caution. Diuretics: increased cardiac toxicity if hypokalaemia occurs.
Metabolism
Flecainide is extensively metabolised (subject to genetic polymorphism), the 2 major metabolites being m-Odealkylated flecainide and m-O-dealkylated lactam of flecainide, both of which may have some activity. Its metabolism appears to involve the cytochrome P450 isoenzyme CYP2D6, which shows genetic polymorphism.Flecainide is excreted mainly in the urine, approximately 30% as unchanged drug and the remainder as metabolites. About 5% is excreted in the faeces. Haemodialysis removes only about 1% of unchanged flecainide.
storage
Desiccate at +4°C
References
1) Rouet and Ducouret (1994), Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle; J. Cardiovasc. Pharmacol.,?24?177 2) Singh?et al. (1984),?The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions; Ann. N.Y. Acad. Sci.,?432?210 3) Banitt?et al.?(1977),?Anti-arrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides; J. Med. Chem.,?20?821 4) Melgari?et al.?(2015),?Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide; J. Mol. Cell. Cardiol.,?86?42
FLECAINIDE ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
FLECAINIDE ACETATE Suppliers
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View Lastest Price from FLECAINIDE ACETATE manufacturers
- Product
- Flecainide acetate 54143-56-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Flecainide acetate 54143-56-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Flecainide acetate 54143-56-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09