ChemicalBook > CAS DataBase List > 2-Methylcinnamic acid

2-Methylcinnamic acid

Product Name
2-Methylcinnamic acid
CAS No.
2373-76-4
Chemical Name
2-Methylcinnamic acid
Synonyms
5-Bromovaniline;2-Methylciamic acid;RARECHEM BK HC T303;TIMTEC-BB SBB003946;2-Methylcinnamicaci;2-METHYLCINNAMIC ACID;o-Methylcinnamic acid;SPECS AI-942/25034752;METHYLCINNAMIC ACID,2-;3-O-TOLYL-ACRYLIC ACID
CBNumber
CB9297335
Molecular Formula
C10H10O2
Formula Weight
162.19
MOL File
2373-76-4.mol
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2-Methylcinnamic acid Property

Melting point:
174-176 °C(lit.)
Boiling point:
228.88°C (rough estimate)
Density 
1.0281 (rough estimate)
refractive index 
1.5766 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
almost transparency in Methanol
form 
powder to crystal
pka
4.5(at 25℃)
color 
White to Almost white
BRN 
2500607
LogP
2.870 (est)
CAS DataBase Reference
2373-76-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-36-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
433101
Product name
2-Methylcinnamic acid, predominantly trans
Purity
99%
Packaging
5g
Price
$29.6
Updated
2025/07/31
TCI Chemical
Product number
M1295
Product name
2-Methylcinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$76
Updated
2025/07/31
TCI Chemical
Product number
M1295
Product name
2-Methylcinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$187
Updated
2025/07/31
TRC
Product number
M304958
Product name
2-Methylcinnamic Acid
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
I238
Product name
2-Methylcinnamic acid, predominantly trans
Packaging
100g
Price
$188
Updated
2021/12/16
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2-Methylcinnamic acid Chemical Properties,Usage,Production

Chemical Properties

White flakes or crystal

Uses

2-Methylcinnamic acid may be used as starting reagent for the total synthesis of the cytotoxic alkaloid, 22-hydroxyacuminatine and for the preparation of (E)-2-methylcinnamic acid i-butylammonium salt.

Definition

ChEBI: 2-Methylcinnamic Acid is a member of cinnamic acids.

General Description

2-Methylcinnamic acid has been reported to exhibit strong anti-fungal activity against white-rot fungus Lenzites betulina and brown-rot fungus Laetiporus sulphureus. Hydrogenation of 2-methylcinnamic acid using Walphos ligands and their biferrocene analogs has been studied.

Synthesis

141-82-2

529-20-4

939-57-1

GENERAL STEPS: 2-Methylbenzaldehyde (50 g, 417 mmol) was dissolved in pyridine (2 eq., 65 mL) under stirring conditions, followed by the addition of malonic acid (86.6 g, 834 mmol). The reaction mixture was heated to reflux for 4-5 hours. Upon completion of the reaction, the mixture was slowly poured into ice water and then acidified with 1N HCl. The precipitated white solid was collected by filtration, washed with water and dried under high vacuum for 3-4 h to give (E)-3-(o-tolyl)acrylic acid (57 g, 87% yield).

References

[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0173
[2] Patent: WO2013/5168, 2013, A2. Location in patent: Page/Page column 32
[3] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5371 - 5374
[4] Journal of Organic Chemistry, 1986, vol. 51, # 7, p. 1120 - 1123
[5] Patent: WO2013/74892, 2013, A1. Location in patent: Page/Page column 39-40

2-Methylcinnamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methylcinnamic acid manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Methylcinnamic Acid 2373-76-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2024-08-20
Henan Fengda Chemical Co., Ltd
Product
2-Methylcinnamic acid 2373-76-4
Price
US $34.00-1.10/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-25
Career Henan Chemical Co
Product
2-Methylcinnamic acid 2373-76-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-99.9%
Supply Ability
100kg
Release date
2020-01-10

2373-76-4, 2-Methylcinnamic acidRelated Search:

POLYMETHACRYLATE Ethyl methacrylate Octadecyl methacrylate 4-Nitrocinnamic acid 3-Nitrocinnamic acid Methyl methacrylate 2-Hydroxyethyl methacrylate Methacrylic acid Butyl methacrylate trans-Cinnamic acid Octyl 4-methoxycinnamate 4-Bromocinnamic acid Ethyl cinnamate Methyl cinnamate Citric acid Ascoric Acid à-methylcinnamic acid,ALPHA-METHYLCINNAMIC ACID,A-METHYLCINNAMIC ACID 9-FLUORENYLIDENEACETIC ACID

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  • 2373-76-4
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  • Carbonyl Compounds
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  • Cinnamic acid
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  • 2373-76-4
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