3-Oxoindane-1-carboxylic acid
- Product Name
- 3-Oxoindane-1-carboxylic acid
- CAS No.
- 29427-69-8
- Chemical Name
- 3-Oxoindane-1-carboxylic acid
- Synonyms
- 3-OXO-1-INDANCARBOXYLIC ACID;1-Indanone-3-carboxylic Acid;3-OXO-INDAN-1-CARBOXYLIC ACID;3-OXOINDANE-1-CARBOXYLIC ACID;3-Oxo-1-indan-2-carboxylic acid;3-OXO-1-INDAN-1-CARBOXYLIC ACID;3-Oxo-1-indancarboxylic acid 98%;3-Oxo-2,3-dihydro-indene-1-carboxylic acid;3-Oxo-indan-1-carboxylic acid methyl ester;2,3-dihydro-3-oxo-1h-indene-1-carboxylicaci
- CBNumber
- CB9305409
- Molecular Formula
- C10H8O3
- Formula Weight
- 176.17
- MOL File
- 29427-69-8.mol
3-Oxoindane-1-carboxylic acid Property
- Melting point:
- 111-113 °C (lit.)
- Boiling point:
- 365.0±41.0 °C(Predicted)
- Density
- 1.384±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.67±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 29427-69-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 410772
- Product name
- 3-Oxo-1-indancarboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $91
- Updated
- 2023/06/20
- Product number
- 410772
- Product name
- 3-Oxo-1-indancarboxylic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $435
- Updated
- 2023/06/20
- Product number
- O990078
- Product name
- 3-Oxoindane-1-carboxylicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 082963
- Product name
- 3-Oxoindane-1-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- N667
- Product name
- 3-Oxoindane-1-carboxylicacid
- Packaging
- 5g
- Price
- $128.9
- Updated
- 2021/12/16
3-Oxoindane-1-carboxylic acid Chemical Properties,Usage,Production
Uses
3-Oxoindane-1-carboxylic Acid is an indan acid and a potential oral hypoglycemic agents.
Definition
ChEBI: 3-oxoindane-1-carboxylic acid is a member of indanones.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 6702, 1984 DOI: 10.1021/ja00334a040
General Description
3-Oxo-1-indancarboxylic acid participates in the synthesis of 3-hydroxymethyl-1-indanol (±). Enantiomeric separation of 3-oxo-1-indancarboxylic acid on liquid chromatography chiral stationary phases (CSPs) by supercritical fluid chromatography (SFC) has been reported. Separation of 3-oxo-1-indancarboxylic acid enantiomers using a new immobilized polysaccharide chiral stationary phase, CHIRALPAK IA with hexane has been described.
Synthesis
1131-15-3
29427-69-8
The general procedure for the synthesis of 3-carbonyl-1-indenoic acid from phenylsuccinic anhydride was as follows: phenylsuccinic anhydride (10 g, 57 mmol) was dissolved in 1,2-dichloroethane (200 mL). The solution was slowly added dropwise to a solution of 1,2-dichloroethane (50 mL) containing aluminum trichloride (17 g, 130 mmol) at 0°C. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour at room temperature. Subsequently, water (50 mL) was added at 0 °C to terminate the reaction. The reaction mixture was extracted with ethyl acetate (3 x 60 mL), the organic phases were combined and concentrated by evaporation. After drying, the light yellow oily product 5A (8.3 g, 83% yield) was obtained.
References
[1] Bulletin de la Societe Chimique de France, 1982, vol. 2, # 5-6, p. 161 - 166
[2] Patent: CN108250128, 2018, A. Location in patent: Paragraph 0195; 0197; 0198; 0199
[3] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 661
[4] Tetrahedron, 2004, vol. 60, # 41, p. 9245 - 9253
[5] Canadian Journal of Chemistry, 1961, vol. 39, p. 2563 - 2571
3-Oxoindane-1-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Oxoindane-1-carboxylic acid manufacturers
- Product
- 3-oxo-1-indancarboxylic Acid 29427-69-8
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- GC>99%
- Supply Ability
- Inquiry
- Release date
- 2023-03-30
- Product
- 3-Oxoindane-1-carboxylic acid 29427-69-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-19