ChemicalBook > CAS DataBase List > CALPAIN INHIBITOR II

CALPAIN INHIBITOR II

Product Name
CALPAIN INHIBITOR II
CAS No.
110115-07-6
Chemical Name
CALPAIN INHIBITOR II
Synonyms
ALLM;Calp II;SUAM 312;AC-LLM-CHO;Ac-Leu-Leu-Met-al;AC-LEU-LEU-MET-CHO;CALPAIN INHIBITOR II;AC-LEU-LEU-METHIONINAL;AC-LEU-LEU-MET-ALDEHYDE;AC-LEU-LEU-L-METHIONINAL
CBNumber
CB9305494
Molecular Formula
C19H35N3O4S
Formula Weight
401.56
MOL File
110115-07-6.mol
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CALPAIN INHIBITOR II Property

Boiling point:
676.5±55.0 °C(Predicted)
Density 
1.076±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
ethanol: 20 mg/mL
form 
powder
pka
13.32±0.46(Predicted)
color 
white
CAS DataBase Reference
110115-07-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
3-10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6060
Product name
Calpain Inhibitor II
Purity
powder
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
A6060
Product name
Calpain Inhibitor II
Purity
powder
Packaging
25mg
Price
$561
Updated
2024/03/01
Sigma-Aldrich
Product number
208721
Product name
ALLM - CAS 110115-07-6 - Calbiochem
Packaging
25mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
15994
Product name
Calpain Inhibitor II
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15994
Product name
Calpain Inhibitor II
Purity
≥98%
Packaging
5mg
Price
$78
Updated
2024/03/01
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CALPAIN INHIBITOR II Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Definition

ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.

General Description

A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

CALPAIN INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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CALPAIN INHIBITOR II Suppliers

China 69 Europe 1 Germany 3 Japan 2 Switzerland 2 United Kingdom 8 United States 21 Global 106
Alabiotech Inc.
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View Lastest Price from CALPAIN INHIBITOR II manufacturers

Career Henan Chemical Co
Product
CALPAIN INHIBITOR II 110115-07-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-12

110115-07-6, CALPAIN INHIBITOR IIRelated Search:

Bismuth hydroxide nitrate oxide, BiO5.1 CALPAIN INHIBITOR I Calpain Inhibitor I CALPAIN INHIBITOR II H-TRP-TRP-GLY-TRP-GLY-THR-MET-LEU-LEU-GLY-LEU-LEU-MET-ILE-CYS-OH GTMLLGLLMICSATE H-LEU-GLY-LEU-LEU-MET-ILE-CYS-SER-ALA-THR-GLU-LYS-LEU-TRP-VAL-OH FUSION GLYCOPROTEIN (92-106) [HUMAN RESPIRATORY SYNCYTIAL VIRUS] BIOTINYL-NEUROPEPTIDE W-23 (HUMAN) CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL) H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-SER-GLY-LEU-LEU-MET-GLY-LEU-OH EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT 3 GAMMA (242-250) [HOMO SAPIENS]/[RATTUS NORVEGICUS] H2N-SLLMWITQV-OH ALPHA-1 ANTITRYPSIN FRAGMENT [HOMO SAPIENS]/[PAPIO HAMADRYAS]/[CERCOPITHECUS AETHIOPS] BIOT-PKPPKPVSKMRMATPLLMQA-OH AC-CCLLMPPPPPLFPPPFF-AMIDE CD74 ANTIGEN (INVARIANT POLYPEPTIDE OF MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II ANTIGEN-ASSOCIATED) (98-117) [HOMO SAPIENS] N-ACETYL-LEU-LEU-MET-H

  • n-acetylleucyl-leucyl-methioninal
  • Ac-Leu-Leu-Met-al
  • N-Acetyl-L-Leu-L-Leu-L-Met-OH
  • Calpain Inhibitor II,96%
  • CALPAIN INHIBITOR II ;AC-LEU-LEU-MET-CHO
  • Calp II
  • SUAM 312
  • CALPAIN INHIBITOR II
  • ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL
  • AC-LLM-CHO
  • AC-LEU-LEU-L-METHIONINAL
  • AC-LEU-LEU-MET-ALDEHYDE
  • AC-LEU-LEU-MET-CHO
  • AC-LEU-LEU-MET-H (ALDEHYDE)
  • AC-LEU-LEU-METHIONINAL
  • ALLM
  • N-AC-LEU-LEU-METHIONINAL
  • N-ACETYL-LEU-LEU-MET-CHO
  • N-ACETYL-LEU-LEU-METHIONINAL
  • N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONAL
  • N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL
  • L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-
  • ALLM (Calpain inhibitor II)
  • 110115-07-6
  • C19H35N3O4S
  • Biochemicals and Reagents
  • BioChemical
  • A to C
  • Calpain I
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Pepetides
  • peptides
  • inhibitor