5-(Z-AMINO)-1-PENTANOL
- Product Name
- 5-(Z-AMINO)-1-PENTANOL
- CAS No.
- 87905-98-4
- Chemical Name
- 5-(Z-AMINO)-1-PENTANOL
- Synonyms
- Benzyl (5-hydroxypentyl)carbaMate;Z-APE(5)-OL;Z-NH-(CH2)5-OH;5-(Z-AMINO)-1-PENTANOL;5-(Cbz-amino)-1-pentanol;N-Cbz-5-hydroxypentylamine;N-CARBOBENZOXY-5-AMINO-1-PENTANOL;BENZYL N-(5-HYDROXYPENTYL)CARBAMATE;N-Benzyloxycarbonyl-5-aminopentanol;5-Amino-N-benzyloxycarbonylpentanol
- CBNumber
- CB9305883
- Molecular Formula
- C13H19NO3
- Formula Weight
- 237.29
- MOL File
- 87905-98-4.mol
5-(Z-AMINO)-1-PENTANOL Property
- Melting point:
- 43-47 °C
- Boiling point:
- 408.2±38.0 °C(Predicted)
- Density
- 1.105±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Dichloromethane (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.68±0.46(Predicted)
- color
- White to Pale Gray to Pale Beige
- BRN
- 4353228
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A599580
- Product name
- 5-Amino-N-benzyloxycarbonylpentanol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FA17797
- Product name
- 5-Amino-N-benzyloxycarbonylpentanol
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FA17797
- Product name
- 5-Amino-N-benzyloxycarbonylpentanol
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 4006AC
- Product name
- Benzyl(5-hydroxypentyl)carbamate
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- FA17797
- Product name
- 5-Amino-N-benzyloxycarbonylpentanol
- Packaging
- 2g
- Price
- $270
- Updated
- 2021/12/16
5-(Z-AMINO)-1-PENTANOL Chemical Properties,Usage,Production
Description
Benzyl (5-hydroxypentyl)carbamate is a linker capable of repairing damaged DNA by binding to the 5'-hydroxyl group on the sugar backbone. It can also bind to DNA ligands and can inhibit cell proliferation in resistant cell lines. However, benzyl (5-hydroxypentyl)carbamate is toxic to cells and can also cause DNA damage and strand breakage.
Chemical Properties
White Solid
Uses
Benzyl (5-hydroxypentyl)carbamate is a linker capable of repairing damaged DNA by binding to the 5'-hydroxyl group on the sugar backbone. Benzyl (5-hydroxypentyl)carbamate can also bind to DNA ligands and can inhibit cell proliferation in resistant cell lines. However, Benzyl (5-hydroxypentyl)carbamate is toxic to cells and can also cause DNA damage and strand breakage.
Synthesis
2508-29-4
501-53-1
87905-98-4
To a stirred mixture of 5-amino-1-pentanol (48.5 mmol, 5.0 g) and sodium bicarbonate (145.4 mmol, 12.2 g) in water (26 mL) was slowly added a solution of benzyl chloroformate (63.1 mmol, 9.0 mL) in THF (26 mL) dropwise at 0-5 °C. After the dropwise addition was completed, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the organic layer was separated by diluting the reaction mixture with EtOAc and water. The organic layer was washed with brine (2 x 30 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to remove the solvent. The crude product was dispersed with a minimal amount of cyclohexane and the resulting solid was filtered and dried under vacuum to give 5-(Cbz-amino)-1-pentanol as a white solid (8.2 g, 71%).1H NMR (400 MHz, CDCl3) δ 7.35 (m, 5H), 5.09 (s, 2H), 4.8 (brs, 1H), 3.65 (m, 2H), and 3.20 (m, 2H), 1.50-1.58 (m, 6H), 1.39 (m, 2H).
References
[1] Journal of the American Chemical Society, 2006, vol. 128, # 12, p. 4058 - 4073
[2] Chemical Communications, 2010, vol. 46, # 48, p. 9119 - 9121
[3] Chemistry - A European Journal, 2010, vol. 16, # 6, p. 1754 - 1760
[4] European Journal of Organic Chemistry, 2011, # 12, p. 2346 - 2353
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 23, p. 5098 - 5111
5-(Z-AMINO)-1-PENTANOL Preparation Products And Raw materials
Raw materials
Preparation Products
5-(Z-AMINO)-1-PENTANOL Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 13761914825
- Fax
- 02131135716
- wulesian@wulechem.com
- Country
- China
- ProdList
- 308
- Advantage
- 58
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4941
- Advantage
- 55
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 0531-88821801 15192360884
- Fax
- 0531-88821802
- 605818151@qq.com
- Country
- China
- ProdList
- 417
- Advantage
- 58