lumateperone (Tosylate)

Product Name: lumateperone (Tosylate)
CAS No.: 1187020-80-9
Chemical Name: lumateperone (Tosylate)
Synonyms: Lumateperone, Caplyta;ITI 007;ITI007 tosylate;ITI722 tosylate;ITI 007 tosylate;ITI 722 tosylate;ITI-007 tosylate;ITI-722 tosylate;Lumateperone(ITI-007);Lumateperone PTSA salt
CBNumber: CB93121116
Molecular Formula: C31H36FN3O4S
Formula Weight: 565.7
MOL File: 1187020-80-9.mol

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lumateperone (Tosylate) Property

storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
form: A solid
color: White to gray
InChIKey: LHAPOGAFBLSJJQ-HXLBOWIHNA-N
SMILES: S(C1C=CC(C)=CC=1)(O)(=O)=O.CN1CCN2[C@@]3([H])CCN(CCCC(C4C=CC(F)=CC=4)=O)C[C@@]3([H])C3=CC=CC1=C32 |&1:16,34,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2866
Product name: Lumateperone tosylate
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $107
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2866
Product name: Lumateperone tosylate
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $430
Updated: 2024/03/01

Biosynth Carbosynth

Product number: BL167386
Product name: Lumateperone tosylate
Packaging: 10mg
Price: $175
Updated: 2021/12/16

ChemScene

Product number: CS-5540
Product name: Lumateperone tosylate
Purity: 99.42%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: 2943DF
Product name: Lumateperone tosylate
Packaging: 10mg
Price: $286
Updated: 2021/12/16

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lumateperone (Tosylate) Chemical Properties,Usage,Production

Uses

lumateperone (Tosylate) is a new second-generation antipsychotic indicated for treating schizophrenia that can potentially alleviate positive and negative symptoms. This drug interacts with dopamine, serotonin, and glutamate, making it unique compared to other antipsychotics. Its highly selective nature for D2R receptors in specific brain regions decreases unfavorable adverse effects and makes it a safer drug[1].

Biochem/physiol Actions

Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (Ki = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID50 = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID50 = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.

References

[1] Kunal Maini. “Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia.” Health Psychology Research (2021): 24932.

lumateperone (Tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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lumateperone (Tosylate) Suppliers

China 116 India 1 United States 10 Global 127

YICHANG TIANRUI BIOPHARM CO., LTD

Tel: 18671799682
Email: 2416114196@qq.com
Country: China
ProdList: 30
Advantage: 58

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 322
Advantage: 58

Chengdu Aupone Pharmaceutical Co.,Ltd.

Tel: 18980796919
Email: 236656639@qq.com
Country: China
ProdList: 30
Advantage: 58

Chengdu Aupone Pharmaceutical Co.,Ltd.

Tel: 18980796919
Email: 236656639@qq.com
Country: China
ProdList: 23
Advantage: 58

Chengdu D-innovation Pharmaceutical Co.，LTD

Tel: 028-85929779 18009044761
Email: pengxing@d-innovation.com
Country: China
ProdList: 231
Advantage: 58

Tianjin Hengze Pharmaceutical Technology Co. , Ltd.

Tel: 022-20629054 15620629054
Email: Iyding@medhonor.com.cn
Country: China
ProdList: 85
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 254
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 977
Advantage: 64

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View Lastest Price from lumateperone (Tosylate) manufacturers

Chengdu Aupone Pharmaceutical Co.Ltd.

Product: Lumateperone Tosylate 1187020-80-9
Price: US $0.00/gram
Min. Order: 5gram
Purity: 99.99%
Supply Ability: 1Tons/year
Release date: 2024-03-14

Hangzhou ICH Biofarm Co., Ltd

Product: lumateperone (Tosylate) 1187020-80-9
Price: US $16000.00/g
Min. Order: 1g
Purity: 99.0%min singleimpurity 0.5%max
Supply Ability: 50KG
Release date: 2023-06-09

1187020-80-9, lumateperone (Tosylate)Related Search:

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lumateperone (Tosylate)

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Lumateperone toluenesulfonic acid (PTSA salt)

Lumateperone PTSA salt

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1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 4-methylbenzenesulfonate

Lumateperone P-toluenesulfonate Salt

ITI 007 tosylate

ITI 722 tosylate

ITI007 tosylate

ITI-007 tosylate

ITI722 tosylate

ITI-722 tosylate

1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 4-methylbenzenesulfonate

Lumateperone Tosylate Salt

1187020-80-9

C24H28FN3OC7H8O3S