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lumateperone (Tosylate)

Product Name
lumateperone (Tosylate)
CAS No.
1187020-80-9
Chemical Name
lumateperone (Tosylate)
Synonyms
Lumateperone, Caplyta;ITI 007;ITI007 tosylate;ITI722 tosylate;ITI 007 tosylate;ITI 722 tosylate;ITI-007 tosylate;ITI-722 tosylate;Lumateperone(ITI-007);Lumateperone PTSA salt
CBNumber
CB93121116
Molecular Formula
C31H36FN3O4S
Formula Weight
565.7
MOL File
1187020-80-9.mol
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lumateperone (Tosylate) Property

storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
form 
A solid
color 
White to gray
optical activity
[α]/D -10 to -14, c =1 in DMSO
InChIKey
LHAPOGAFBLSJJQ-HXLBOWIHNA-N
SMILES
S(C1C=CC(C)=CC=1)(O)(=O)=O.CN1CCN2[C@@]3([H])CCN(CCCC(C4C=CC(F)=CC=4)=O)C[C@@]3([H])C3=CC=CC1=C32 |&1:16,34,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2866
Product name
Lumateperone tosylate
Purity
≥98% (HPLC)
Packaging
10MG
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2866
Product name
Lumateperone tosylate
Purity
≥98% (HPLC)
Packaging
50MG
Price
$430
Updated
2024/03/01
ChemScene
Product number
CS-5540
Product name
Lumateperone tosylate
Purity
99.42%
Packaging
5mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
BL167386
Product name
Lumateperone tosylate
Packaging
10mg
Price
$175
Updated
2021/12/16
ChemScene
Product number
CS-5540
Product name
Lumateperone tosylate
Purity
99.42%
Packaging
10mg
Price
$180
Updated
2021/12/16
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lumateperone (Tosylate) Chemical Properties,Usage,Production

Uses

lumateperone (Tosylate) is a new second-generation antipsychotic indicated for treating schizophrenia that can potentially alleviate positive and negative symptoms. This drug interacts with dopamine, serotonin, and glutamate, making it unique compared to other antipsychotics. Its highly selective nature for D2R receptors in specific brain regions decreases unfavorable adverse effects and makes it a safer drug[1].

Biochem/physiol Actions

Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (Ki = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID50 = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID50 = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.

References

[1] Kunal Maini. “Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia.” Health Psychology Research (2021): 24932.

lumateperone (Tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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lumateperone (Tosylate) Suppliers

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View Lastest Price from lumateperone (Tosylate) manufacturers

Guangzhou Tosun Pharmaceutical Ltd
Product
lumateperone Tosylate 1187020-80-9
Price
US $0.00-0.00/kg
Min. Order
5kg
Purity
98%-102%
Supply Ability
200kg
Release date
2024-12-27
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Lumateperone Tosylate 1187020-80-9
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-12-30
Chengdu Aupone Pharmaceutical Co.Ltd.
Product
Lumateperone Tosylate 1187020-80-9
Price
US $0.00/gram
Min. Order
5gram
Purity
99.99%
Supply Ability
1Tons/year
Release date
2024-03-14

1187020-80-9, lumateperone (Tosylate)Related Search:

TRIS(PENTAFLUOROPHENYL)BORANE 4'-Hydroxyacetophenone Aniline 2-FLUOROPHENYL CYCLOPENTYL KETONE

  • 1-(4-Fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone 4-methylbenzenesulfonate (1:1)
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