lumateperone (Tosylate)

Product Name: lumateperone (Tosylate)
CAS No.: 1187020-80-9
Chemical Name: lumateperone (Tosylate)
Synonyms: Lumateperone, Caplyta;ITI 007;ITI007 tosylate;ITI722 tosylate;ITI 007 tosylate;ITI 722 tosylate;ITI-007 tosylate;ITI-722 tosylate;Lumateperone(ITI-007);Lumateperone PTSA salt
CBNumber: CB93121116
Molecular Formula: C31H36FN3O4S
Formula Weight: 565.7
MOL File: 1187020-80-9.mol

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lumateperone (Tosylate) Property

storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
form: A solid
color: White to gray
optical activity: [α]/D -10 to -14, c =1 in DMSO
InChIKey: LHAPOGAFBLSJJQ-HXLBOWIHNA-N
SMILES: S(C1C=CC(C)=CC=1)(O)(=O)=O.CN1CCN2[C@@]3([H])CCN(CCCC(C4C=CC(F)=CC=4)=O)C[C@@]3([H])C3=CC=CC1=C32 |&1:16,34,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2866
Product name: Lumateperone tosylate
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $93.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2866
Product name: Lumateperone tosylate
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $376
Updated: 2025/07/31

ChemScene

Product number: CS-5540
Product name: Lumateperone tosylate
Purity: 99.42%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BL167386
Product name: Lumateperone tosylate
Packaging: 10mg
Price: $175
Updated: 2021/12/16

ChemScene

Product number: CS-5540
Product name: Lumateperone tosylate
Purity: 99.42%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

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lumateperone (Tosylate) Chemical Properties,Usage,Production

Uses

lumateperone (Tosylate) is a new second-generation antipsychotic indicated for treating schizophrenia that can potentially alleviate positive and negative symptoms. This drug interacts with dopamine, serotonin, and glutamate, making it unique compared to other antipsychotics. Its highly selective nature for D2R receptors in specific brain regions decreases unfavorable adverse effects and makes it a safer drug[1].

Biochem/physiol Actions

Lumateperone tosylate (ITI-007) is an orally active, potent 5-HT2A antagonist, postsynaptic D2 antagonist, and serotonin transporter SERT inhibitor (Ki = 0.5, 32, 62 nM, respectively) with in vivo antipsychotic efficacy and no effect toward receptors associated with cognitive and metabolic side effects of antipsychotic drugs (e.g., H1, 5-HT2C, muscarinic). ITI-007 blocks DOI-induced headtwitch (ID50 = 0.09 mg/kg, po.) and D-AMPH-induced hyperlocomotion in mice (ID50 = 0.95 mg/kg, po.), while also acting as a partial agonist at presynaptic striatal D2 receptors.

References

[1] Kunal Maini. “Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia.” Health Psychology Research (2021): 24932.

lumateperone (Tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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lumateperone (Tosylate) Suppliers

China 151 India 3 United States 10 Global 164

YICHANG TIANRUI BIOPHARM CO., LTD

Tel: 13469840438
Email: caiweiguo@renfu.com.cn
Country: China
ProdList: 49
Advantage: 58

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 252
Advantage: 58

Chengdu Aupone Pharmaceutical Co.,Ltd.

Tel: 18980796919
Email: 236656639@qq.com
Country: China
ProdList: 30
Advantage: 58

Chengdu Aupone Pharmaceutical Co.,Ltd.

Tel: 18980796919; 18980796919
Email: 236656639@qq.com
Country: China
ProdList: 29
Advantage: 58

Chengdu D-innovation Pharmaceutical Co.，LTD

Tel: 028-85929779 18881048017
Email: chenxuanruo@d-innovation.com
Country: China
ProdList: 262
Advantage: 58

Tianjin Zhennuo Pharmaceutical Group Co., Ltd

Tel: 15620629054
Email: ivyding@medhonor.com.cn
Country: China
ProdList: 64
Advantage: 58

Tsingxin Biopharmaceutical Co., Ltd

Tel: 18908011947
Email: 3903467217@qq.com
Country: China
ProdList: 134
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

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View Lastest Price from lumateperone (Tosylate) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: lumateperone (Tosylate) 1187020-80-9
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-13

Guangzhou Tosun Pharmaceutical Ltd

Product: lumateperone Tosylate 1187020-80-9
Price: US $0.00-0.00/kg
Min. Order: 5kg
Purity: 98%-102%
Supply Ability: 200kg
Release date: 2024-12-27

Shaanxi Dideu New Materials Co. Ltd

Product: lumateperone (Tosylate) 1187020-80-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-24

1187020-80-9, lumateperone (Tosylate)Related Search:

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1-(4-Fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone 4-methylbenzenesulfonate (1:1)

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lumateperone (Tosylate)

ITI 007

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Lumateperone toluenesulfonic acid (PTSA salt)

Lumateperone PTSA salt

Dopamine Receptor,ITI007,schizophrenia,lumateperone Tosylate,Inhibitor,inhibit,dopamine D1 receptor,5-HT2A,5-hydroxytryptamine Receptor,presynaptic D2 receptor,5-HT Receptor,Lumateperone,ITI 007,postsynaptic D2 receptor,Serotonin Receptor

1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 4-methylbenzenesulfonate

Lumateperone P-toluenesulfonate Salt

ITI 007 tosylate

ITI 722 tosylate

ITI007 tosylate

ITI-007 tosylate

ITI722 tosylate

ITI-722 tosylate

Lumateperone Tosylate Salt

lumateperone Tosylate, 10 mM in DMSO

Lumiperidone p-toluenesulfonate

Lumateperone Impurity 48

1187020-80-9

C24H28FN3OC7H8O3S