Description
ChemicalBook > CAS DataBase List > 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE

2-MERCAPTO-5-METHOXYBENZIMIDAZOLE

Description
Product Name
2-MERCAPTO-5-METHOXYBENZIMIDAZOLE
CAS No.
37052-78-1
Chemical Name
2-MERCAPTO-5-METHOXYBENZIMIDAZOLE
Synonyms
5-METHOXY-1H-BENZO[D]IMIDAZOLE-2-THIOL;Omeprazole Impurity A;OMeprazole Related CoMpound B;5-METHOXY-2-BENZIMIDAZOLETHIOL;5-METHOXY-2-MERCAPTOBENZIMIDAZOLE;5-methoxy-1H-benzoimidazole-2-thiol;H 118/87;5-Methoxy;OMEP IM-A;TIMTEC-BB SBB000219
CBNumber
CB9313620
Molecular Formula
C8H8N2OS
Formula Weight
180.23
MOL File
37052-78-1.mol
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2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Property

Melting point:
261-263 °C(lit.)
Boiling point:
309.4±44.0 °C(Predicted)
Density 
1.2425 (rough estimate)
vapor pressure 
0.001Pa at 25℃
refractive index 
1.5690 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Sparingly)
form 
Powder
pka
10.13±0.30(Predicted)
color 
Off-white to light yellow-brown
Water Solubility 
insoluble
Sensitive 
Air Sensitive
BRN 
3605123
LogP
1.52-2.399
CAS DataBase Reference
37052-78-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-37-22
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382485
Product name
5-Methoxy-2-benzimidazolethiol
Purity
99%
Packaging
5g
Price
$52.7
Updated
2024/03/01
Sigma-Aldrich
Product number
1478480
Product name
Omeprazole Related Compound B
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$1380
Updated
2024/03/01
TCI Chemical
Product number
M1256
Product name
2-Mercapto-5-methoxybenzimidazole
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$90
Updated
2024/03/01
Alfa Aesar
Product number
B20570
Product name
2-Mercapto-5-methoxybenzimidazole, 99%
Packaging
5g
Price
$26.65
Updated
2024/03/01
Alfa Aesar
Product number
B20570
Product name
2-Mercapto-5-methoxybenzimidazole, 99%
Packaging
25g
Price
$94.3
Updated
2023/06/20
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2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Chemical Properties,Usage,Production

Description

2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfonyl]-1H-benzimidazole, 5-methoxy-2[[(4-methoxy-3, 5-dimethylpyridin-2-yl-1-oxide) methyl] sulfonyl]-1H-benzimidazole as well as tris[μ-1,2-bis(diphenylphosphino)ethane]-1:2κ2P:P′;1:3κ2P:P′;2:3κ2P:P′-di-μ-bromido-1:2κ4Br:Br-bromido-3κBr-tricopper(I) acetone hemisolvate. Furthermore, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole1. Finally, it acts as an intermediate for manufacture of the anti-ulcer drug Omeprazole.

Chemical Properties

off-white to light yellowish-brown powder

Uses

Reagent used in the synthesis of COX-2 inhibitors

Uses

2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. Further, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole.

Uses

5-Methoxy-2-benzimidazolethiol may be used in the preparation of compounds present as contaminants in omeprazole, such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. It may be used in the synthesis of tris[μ-1,2-bis(diphenylphosphino)ethane]-1:2κ2P:P′;1:3κ2P:P′;2:3κ2P:P′-di-μ-bromido-1:2κ4Br:Br-bromido-3κBr-tricopper(I) acetone hemisolvate.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Flammability and Explosibility

Not classified

2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

Ufiprazole Omeprazole
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2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Suppliers

Americas 1 Belgium 3 Canada 7 CHINA 553 Czech Republic 1 Europe 5 France 3 Germany 6 India 107 Japan 7 Slovakia 1 South Korea 2 Sweden 2 Switzerland 5 Ukraine 1 United Kingdom 15 United States 54 Global 773
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Fine Corporation
Tel
--
Fax
--
Email
info@fine-c.jp
Country
Japan
ProdList
1427
Advantage
58
Showa Kako Corporation
Tel
--
Fax
--
Email
tanaka@showakako.co.jp
Country
Japan
ProdList
23
Advantage
58
K. Sakai & Co., Ltd.
Tel
--
Fax
--
Email
em@ksakai.co.jp
Country
Japan
ProdList
957
Advantage
58
OuchiShinko Chemical Industrial Co., Ltd
Tel
--
Fax
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Email
support@jp-noc.co.jp
Country
Japan
ProdList
185
Advantage
71
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
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Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
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Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
2-MERCAPTO-5-METHOXYBENZIMIDAZOLE 37052-78-1
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-08
Jinan Finer Chemical Co., Ltd
Product
5-Methoxy-2-mercaptobenzimidazole 37052-78-1
Price
US $0.00/Kg/Drum
Min. Order
1ASSAYS
Purity
99%
Supply Ability
50mt
Release date
2019-11-01
Hebei Longbang Technology Co., Ltd
Product
2-MERCAPTO-5-METHOXYBENZIMIDAZOLE 37052-78-1
Price
US $6.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-04-29

37052-78-1, 2-MERCAPTO-5-METHOXYBENZIMIDAZOLERelated Search:

2-Ethylhexyl mercaptoacetate Mercaptoacetic acid 2-Mercaptobenzimidazole 2-Methoxyethanol Benzimidazole 2-Methylbenzimidazole 3-Mercaptopropionic acid Ufiprazole OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Calcium thioglycolate Omeprazole 5-METHOXY-2-[((4-METHOXY-3,5-DIMETHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL]-BENZIMIDAZOLE Esomeprazole Impurity 3 (S)-4-Desmethoxy-4-chloro Omeprazole 4-Hydroxy Omeprazole Omeprazole EP Impurity F Omeprazole Sulfone N-Oxide EsoMeprazole related substance H431/41

  • 5-Methoxye-2-mercaplobenzinidazole
  • TIMTEC-BB SBB000219
  • 5-METHOXY-1H-BENZO[D]IMIDAZOLE-2-THIOL
  • 5-Methoxybenzimidazole-2-thiol
  • 5-METHOXY-2-THIOBENZIMIDAZOLE
  • 5-METHOXY-2-MERCAPTOBENZIMIDAZOLE
  • 5-METHOXY-2-BENZIMIDAZOLETHIOL
  • 2-MERCAPTO-5-METHOXY-1H-BENZIMIDAZOLE
  • 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE
  • 1,3-DIHYDRO-5-METHOXY-2H-BENZIMIDAZOLE-2-THIONE
  • LABOTEST-BB LT01596137
  • 2-Mercapoto-5-Methoxy-1H-benzimidazole
  • Esomeprazole Sodium Impurity Ⅴ:5-Methoxy-2-mercaptobenzimidazole
  • 5-Methoxy
  • H 118/87
  • 5-methoxy-2(1H)-benzimidazolinethione
  • 2-Mercato-5-methoxy benzimidazole
  • 5-METHOXY-2-THIOHYDROXYBENZIMIDAZOLE(INTERMEDIATE OF OMEPRAZOLE)
  • 2-Mercapto-5-MethoxyBenzimidazole(ForOmeprazole)
  • 5-METHOXY-2-BENZIMIDAZOLEETHIOL
  • 2-Mercapto-5-methoxy-1H-benzim
  • 5-methoxy-2-thiohydroxy benzimidazole
  • 5-Methoxy-2-thiobenzimidazole 99%
  • 2H-Benzimidazole-2-thione,1,3-dihydro-5-methoxy-(9CI)
  • 5-methoxy-1H-benzoimidazole-2-thiol
  • 5-METHOXY-2-MERCAPTOBENIMIDAZOLEOMEPRAZOLE
  • 5-METHOXYL-2-MERCAPTOBENZIMIDAZOLE
  • 5-Methoxy-1H-1,3-benzodiazole-2-thiol
  • 5-Methoxy-1,3-dihydrobenzimidazole-2-thione
  • 5-Methoxy-2-benzimidazolethiol ,99%
  • 5-METHOXY-2-MERCAPTOBENZIMIDAZOLE, 99+%
  • 6-Methoxy-1H-benzimidazole-2-thiol
  • 6-Methoxy-2-mercapto-1H-benzimidazole
  • 5-Methoxy-2-mercapto
  • 5-Methoxy-1H-benzimidazole-2-thiol 99%
  • (S)-Omeprazole Intermediate 2
  • 5-Methoxy-2-thio-1H-benzimidazole
  • Omeprazole EP impurity-A (USP RC B)
  • Esomeprazole impurity A
  • Omeprazole Imp. A(EP)(USP RC B): (5-Methoxy-1H-Benzimidazole-2-Thiol)
  • 2-mercapto-5-methyoxy benzimidazole (omeprazole-benzimidazole)
  • 5-DIFLUOROMETHOXY-2-MERCAPTO- BENZIMIDZO LE
  • Omeprazole RCB (USP)
  • Esomeprazol EP Impurity A(Omeprazole EP Impurity A)
  • 2-MERCAPTO -5-METHOXY BENZIMIDAZOLE (METOXITIONA )
  • OMEP IM-A
  • Omeprazole Impurity A
  • EsoMeprazole related substance A
  • EsoMeprazol iMpurity A
  • OMeprazole IMpurity-A (EP)
  • OMeprazole EP IMpurity A
  • 5-Methoxy-1H-benzimidazole-2-thiol, 2-Mercapto-5-methoxy-1H-benzimidazole
  • 5-Methoxy-2-thio-1H-benzimidazole 99%
  • 5-Methoxy-1H-benzo[d]iMidazole-2(3H)-thione
  • OMeprazole IMpurity A (5-Methoxy-1H-BenziMidazole-2-Thiol)
  • 5-Methoxy-1H-benzo[d]iMidazole-2-thiol (RelCpd A)
  • 2H-BenziMidazole-2-thione, 1,3-dihydro-5-Methoxy-
  • 2-Mercatto-5-Methoxy-1H-BenziMidazde