Carbenoxolone
- Product Name
- Carbenoxolone
- CAS No.
- 5697-56-3
- Chemical Name
- Carbenoxolone
- Synonyms
- bioral;biogastrone;Carbenoxolon;CARBENOXOLONE;Carbenoxolona;CARBENOXOLONE [U;Carbenoxolone-d4;CARBENOXOLONE(RG);glycyrrhetnic acid;Carbenoxolone (YP 003)
- CBNumber
- CB9314814
- Molecular Formula
- C34H50O7
- Formula Weight
- 570.76
- MOL File
- 5697-56-3.mol
Carbenoxolone Property
- Melting point:
- 291-294 °C
- alpha
- D20 +128° (chloroform)
- Boiling point:
- 553.75°C (rough estimate)
- Density
- 1.20
- refractive index
- 1.5820 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pKa 6.7 (Uncertain)
- color
- Cream crystals
- Water Solubility
- 6.621mg/L(24 ºC)
- CAS DataBase Reference
- 5697-56-3(CAS DataBase Reference)
- EPA Substance Registry System
- Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3.beta.,20.beta.)- (5697-56-3)
Safety
- Toxicity
- LD50 orl-rat: 2450 mg/kg OYYAA2 19,323,80
N-Bromosuccinimide Price
- Product number
- C175903
- Product name
- Carbenoxolone
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C175903
- Product name
- Carbenoxolone
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 076221
- Product name
- (3Beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 076221
- Product name
- (3Beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
- Purity
- 95+%
- Packaging
- 10g
- Price
- $179
- Updated
- 2021/12/16
- Product number
- W7055
- Product name
- Carbenoxolone
- Packaging
- 5g
- Price
- $212
- Updated
- 2021/12/16
Carbenoxolone Chemical Properties,Usage,Production
Originator
Biogastrone,Winthrop,UK,1963
Uses
Glucocorticoid.
Manufacturing Process
23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution
of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by
30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry
pyridine. The solution was heated on a boiling water bath for ten hours and
then poured into excess of dilute hydrochloric acid and ice. The fine gray
precipitate formed was filtered off, washed with water, dissolved in chloroform,
and the solution repeatedly extracted with dilute hydrochloric acid and later
with water. It was dried over sodium sulfate and evaporated to dryness.
Crystallization from methanol, using charcoal to effect decolorization, gave the
hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with
previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was
ground with a dilute (5%) aqueous solution containing two molecular
proportions of sodium hydroxide. The solution was filtered and evaporated in
vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a
creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from
licorice root.
Therapeutic Function
Antiinflammatory (gastric)
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Human systemic effects byingestion: muscle weakness and flaccid paralysis. Whenheated to decomposition it emits acrid smoke and fumes.
Carbenoxolone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbenoxolone manufacturers
- Product
- Carbenoxolone 5697-56-3
- Price
- US $400.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2021-06-02
- Product
- Carbenoxolone 5697-56-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- Carbenoxolone 5697-56-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19