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Carbenoxolone

Product Name
Carbenoxolone
CAS No.
5697-56-3
Chemical Name
Carbenoxolone
Synonyms
bioral;biogastrone;Carbenoxolon;CARBENOXOLONE;Carbenoxolona;CARBENOXOLONE [U;Carbenoxolone-d4;CARBENOXOLONE(RG);glycyrrhetnic acid;Carbenoxolone (YP 003)
CBNumber
CB9314814
Molecular Formula
C34H50O7
Formula Weight
570.76
MOL File
5697-56-3.mol
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Carbenoxolone Property

Melting point:
291-294 °C
alpha 
D20 +128° (chloroform)
Boiling point:
553.75°C (rough estimate)
Density 
1.20
refractive index 
1.5820 (estimate)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
pKa 6.7 (Uncertain)
color 
Cream crystals
Water Solubility 
6.621mg/L(24 ºC)
CAS DataBase Reference
5697-56-3(CAS DataBase Reference)
EPA Substance Registry System
Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3.beta.,20.beta.)- (5697-56-3)
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Safety

Toxicity
LD50 orl-rat: 2450 mg/kg OYYAA2 19,323,80
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C175903
Product name
Carbenoxolone
Packaging
500mg
Price
$60
Updated
2021/12/16
TRC
Product number
C175903
Product name
Carbenoxolone
Packaging
1g
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
076221
Product name
(3Beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
Purity
95+%
Packaging
5g
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
076221
Product name
(3Beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
Purity
95+%
Packaging
10g
Price
$179
Updated
2021/12/16
AK Scientific
Product number
W7055
Product name
Carbenoxolone
Packaging
5g
Price
$212
Updated
2021/12/16
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Carbenoxolone Chemical Properties,Usage,Production

Originator

Biogastrone,Winthrop,UK,1963

Uses

Glucocorticoid.

Manufacturing Process

23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.

Therapeutic Function

Antiinflammatory (gastric)

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Human systemic effects byingestion: muscle weakness and flaccid paralysis. Whenheated to decomposition it emits acrid smoke and fumes.

Carbenoxolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbenoxolone Suppliers

Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5877
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653713 17501653715
Email
xingui2022@126.com
Country
China
ProdList
10043
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9798
Advantage
50
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2984
Advantage
50
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20811
Advantage
60
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View Lastest Price from Carbenoxolone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Carbenoxolone 5697-56-3
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30
Hebei Mojin Biotechnology Co., Ltd
Product
Carbenoxolone 5697-56-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-19
Hebei Mojin Biotechnology Co., Ltd
Product
Carbenoxolone 5697-56-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-30

5697-56-3, CarbenoxoloneRelated Search:


  • CARBENOXOLONE
  • 3β-[(β-Carboxypropionyl)oxy]-11-oxoolean-12-en-30-oic acid
  • glycyrrhetinic acid hydrogen succinate
  • 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate
  • Olean-12-en-29-oic acid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,(3b,20b)-
  • CARBENOXOLONE(RG)
  • 2-Methylidene-2,3-dihydrofuran-3-one
  • CARBENOXOLONE [U
  • (3beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
  • 3-beta-(3-carboxypropionyloxy)-11-oxo-olean-12-en-30-oicacid
  • 3-beta-hydroxy-11-oxo-olean-12-en-30-oicacihydrogensuccinate
  • biogastrone
  • bioral
  • glycyrrhetnic acid
  • Carbenoxolone (YP 003)
  • Carbenoxolone-d4
  • Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3β,20β)-
  • Carbenoxolon
  • 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-OLEAN-12-EN-29-OIC ACID
  • Carbenoxolone USP/EP/BP
  • Carbenoxolona
  • 5697-56-3
  • C34H50O7
  • Pentacyclic Triterpenes