Carbenoxolone

ChemicalBook > CAS DataBase List > Carbenoxolone

Product Name: Carbenoxolone
CAS No.: 5697-56-3
Chemical Name: Carbenoxolone
Synonyms: bioral;biogastrone;Carbenoxolon;CARBENOXOLONE;Carbenoxolona;CARBENOXOLONE [U;Carbenoxolone-d4;CARBENOXOLONE(RG);glycyrrhetnic acid;Carbenoxolone (YP 003)
CBNumber: CB9314814
Molecular Formula: C34H50O7
Formula Weight: 570.76
MOL File: 5697-56-3.mol

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Carbenoxolone Property

Melting point:: 291-294 °C
alpha: D20 +128° (chloroform)
Boiling point:: 553.75°C (rough estimate)
Density: 1.20
refractive index: 1.5820 (estimate)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: pKa 6.7 (Uncertain)
color: Cream crystals
Water Solubility: 6.621mg/L(24 ºC)
CAS DataBase Reference: 5697-56-3(CAS DataBase Reference)
EPA Substance Registry System: Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3.beta.,20.beta.)- (5697-56-3)

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Safety

Toxicity: LD50 orl-rat: 2450 mg/kg OYYAA2 19,323,80

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C175903
Product name: Carbenoxolone
Packaging: 500mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C175903
Product name: Carbenoxolone
Packaging: 1g
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 076221
Product name: (3Beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
Purity: 95+%
Packaging: 1g
Price: $47
Updated: 2021/12/16

Matrix Scientific

Product number: 076221
Product name: (3Beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
Purity: 95+%
Packaging: 5g
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 076221
Product name: (3Beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
Purity: 95+%
Packaging: 10g
Price: $179
Updated: 2021/12/16

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Carbenoxolone Chemical Properties,Usage,Production

Originator

Biogastrone,Winthrop,UK,1963

Uses

Glucocorticoid.

Manufacturing Process

23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.

Therapeutic Function

Antiinflammatory (gastric)

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Human systemic effects byingestion: muscle weakness and flaccid paralysis. Whenheated to decomposition it emits acrid smoke and fumes.

Carbenoxolone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carbenoxolone manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Carbenoxolone 5697-56-3
Price: US $400.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2021-06-02

Hebei Weibang Biotechnology Co., Ltd

Product: Carbenoxolone 5697-56-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-09-14

Hebei Mojin Biotechnology Co., Ltd

Product: Carbenoxolone 5697-56-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-19

5697-56-3, CarbenoxoloneRelated Search:

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CARBENOXOLONE

3β-[(β-Carboxypropionyl)oxy]-11-oxoolean-12-en-30-oic acid

glycyrrhetinic acid hydrogen succinate

3beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate

Olean-12-en-29-oic acid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,(3b,20b)-

CARBENOXOLONE(RG)

2-Methylidene-2,3-dihydrofuran-3-one

CARBENOXOLONE [U

(3beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid

3-beta-(3-carboxypropionyloxy)-11-oxo-olean-12-en-30-oicacid

3-beta-hydroxy-11-oxo-olean-12-en-30-oicacihydrogensuccinate

biogastrone

bioral

glycyrrhetnic acid

Carbenoxolone (YP 003)

Carbenoxolone-d4

Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3β,20β)-

Carbenoxolon

3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-OLEAN-12-EN-29-OIC ACID

Carbenoxolone USP/EP/BP

Carbenoxolona

5697-56-3

C34H50O7

Pentacyclic Triterpenes