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Carbenoxolone disodium

Product Name
Carbenoxolone disodium
CAS No.
7421-40-1
Chemical Name
Carbenoxolone disodium
Synonyms
neogel;sanodin;duogastrone;pyrogastrone;20-beta)-3-bet;ulcus-tablinen;sodiumcarbenoxolone;CARBENOXOLONE SODIUM;Carbenoxalone Sodium;Carbenoxolone disodi
CBNumber
CB3680281
Molecular Formula
C34H48Na2O7
Formula Weight
614.72
MOL File
7421-40-1.mol
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Carbenoxolone disodium Property

storage temp. 
2-8°C
pka
pKa1 4.18; pKa2 5.52(at 25℃)
Water Solubility 
Soluble in water to 100 mM.
CAS DataBase Reference
7421-40-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36
Safety Statements 
26-36
WGK Germany 
3
RTECS 
RK0250000
Toxicity
LD50 in male mice (mg/kg): 198 i.v.; 120 i.p.; in male rats (mg/kg): 3200 orally (Robson, Sullivan)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C4790
Product name
Carbenoxolone disodium salt
Purity
≥98%
Packaging
5g
Price
$135
Updated
2021/03/22
Sigma-Aldrich
Product number
C4790
Product name
Carbenoxolone disodium salt
Purity
≥98%
Packaging
1g
Price
$42
Updated
2021/03/22
Alfa Aesar
Product number
J63714
Product name
Carbenoxolone disodium salt, 97+%
Packaging
1g
Price
$45
Updated
2021/03/22
Alfa Aesar
Product number
J63714
Product name
Carbenoxolone disodium salt, 97+%
Packaging
5g
Price
$174
Updated
2021/03/22
Cayman Chemical
Product number
18240
Product name
Carbenoxolone (sodium salt)
Purity
≥98%
Packaging
5g
Price
$129
Updated
2021/03/22
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Carbenoxolone disodium Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Biogastrone,Winthrop,UK,1963

Uses

Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative

Uses

beta-adrenergic agonist, growth stimulant

Manufacturing Process

23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.

Therapeutic Function

Antiinflammatory (gastric)

Biological Activity

Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.

Carbenoxolone disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbenoxolone disodium Suppliers

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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021-54306202- ; ;
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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BOC Sciences
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United States
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Shanghai TaoShu Biochemical Technology Co., Ltd.
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021-33632979
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service1@targetmol.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200
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028-81705658
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2851167785@qq.com
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Hainan Manfangyuan Pharmaceutical Chemical Co., Ltd.
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0898-66518050
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+86 (898) 6677-5768
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China
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Sigma-Aldrich
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021-61415566- ;
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China
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48786
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
Country
United States
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View Lastest Price from Carbenoxolone disodium manufacturers

Dideu Industries Group Limited
Product
Carbenoxolone disodium USP/EP/BP 7421-40-1
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-02
Shaanxi Dideu Medichem Co. Ltd
Product
Carbenoxolone disodium 7421-40-1
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30
Career Henan Chemical Co
Product
Carbenoxolone disodium 7421-40-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

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