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Carbenoxolone disodium

Product Name
Carbenoxolone disodium
CAS No.
7421-40-1
Chemical Name
Carbenoxolone disodium
Synonyms
neogel;sanodin;duogastrone;pyrogastrone;20-beta)-3-bet;ulcus-tablinen;sodiumcarbenoxolone;CARBENOXOLONE SODIUM;Carbenoxalone Sodium;Carbenoxolone disodi
CBNumber
CB3680281
Molecular Formula
C34H48Na2O7
Formula Weight
614.72
MOL File
7421-40-1.mol
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Carbenoxolone disodium Property

Melting point:
>275°C (dec.)
storage temp. 
2-8°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
pka
pKa1 4.18; pKa2 5.52(at 25℃)
color 
White to Off-White
Water Solubility 
Soluble in water to 100 mM.
Stability:
Hygroscopic
LogP
7.083 (est)
CAS DataBase Reference
7421-40-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36
Safety Statements 
26-36
WGK Germany 
3
RTECS 
RK0250000
Toxicity
LD50 in male mice (mg/kg): 198 i.v.; 120 i.p.; in male rats (mg/kg): 3200 orally (Robson, Sullivan)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C4790
Product name
Carbenoxolone disodium salt
Purity
≥98%
Packaging
1g
Price
$54.3
Updated
2024/03/01
Sigma-Aldrich
Product number
C4790
Product name
Carbenoxolone disodium salt
Purity
≥98%
Packaging
5g
Price
$226
Updated
2024/03/01
Alfa Aesar
Product number
J63714
Product name
Carbenoxolone disodium salt, 97+%
Packaging
1g
Price
$45.65
Updated
2024/03/01
Alfa Aesar
Product number
J63714
Product name
Carbenoxolone disodium salt, 97+%
Packaging
5g
Price
$191.65
Updated
2024/03/01
Cayman Chemical
Product number
18240
Product name
Carbenoxolone (sodium salt)
Purity
≥98%
Packaging
1g
Price
$38
Updated
2024/03/01
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Carbenoxolone disodium Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Biogastrone,Winthrop,UK,1963

Uses

Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.

Uses

Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative

Uses

beta-adrenergic agonist, growth stimulant

Definition

ChEBI: Carbenoxolone sodium is a triterpenoid.

Manufacturing Process

23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.

Therapeutic Function

Antiinflammatory (gastric)

General Description

Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.

Biological Activity

Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.

storage

Store at +4°C

References

[1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.
[2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.

Carbenoxolone disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carbenoxolone disodium manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Carbenoxolone disodium 7421-40-1
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30
Hebei Mojin Biotechnology Co., Ltd
Product
Carbenoxolone disodium 7421-40-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-19
Dideu Industries Group Limited
Product
Carbenoxolone disodium 7421-40-1
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-02

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  • 7421-40-1
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  • Asymmetric Synthesis
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