ChemicalBook > CAS DataBase List > Carbenoxolone disodium
Carbenoxolone disodium
- Product Name
- Carbenoxolone disodium
- CAS No.
- 7421-40-1
- Chemical Name
- Carbenoxolone disodium
- Synonyms
- neogel;sanodin;duogastrone;pyrogastrone;20-beta)-3-bet;ulcus-tablinen;sodiumcarbenoxolone;CARBENOXOLONE SODIUM;Carbenoxalone Sodium;Carbenoxolone disodi
- CBNumber
- CB3680281
- Molecular Formula
- C34H48Na2O7
- Formula Weight
- 614.72
- MOL File
- 7421-40-1.mol
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Carbenoxolone disodium Property
- Melting point:
- >275°C (dec.)
- storage temp.
- 2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- pKa1 4.18; pKa2 5.52(at 25℃)
- color
- White to Off-White
- Water Solubility
- Soluble in water to 100 mM.
- Stability:
- Hygroscopic
- LogP
- 7.083 (est)
- CAS DataBase Reference
- 7421-40-1(CAS DataBase Reference)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C4790
- Product name
- Carbenoxolone disodium salt
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $56
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- C4790
- Product name
- Carbenoxolone disodium salt
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $233
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 18240
- Product name
- Carbenoxolone (sodium salt)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $38
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18240
- Product name
- Carbenoxolone (sodium salt)
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $158
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18240
- Product name
- Carbenoxolone (sodium salt)
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $279
- Updated
- 2024/03/01
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Carbenoxolone disodium Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Biogastrone,Winthrop,UK,1963
Uses
Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.
Uses
Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative
Uses
beta-adrenergic agonist, growth stimulant
Definition
ChEBI: Carbenoxolone sodium is a triterpenoid.
Manufacturing Process
23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution
of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by
30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry
pyridine. The solution was heated on a boiling water bath for ten hours and
then poured into excess of dilute hydrochloric acid and ice. The fine gray
precipitate formed was filtered off, washed with water, dissolved in chloroform,
and the solution repeatedly extracted with dilute hydrochloric acid and later
with water. It was dried over sodium sulfate and evaporated to dryness.
Crystallization from methanol, using charcoal to effect decolorization, gave the
hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with
previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was
ground with a dilute (5%) aqueous solution containing two molecular
proportions of sodium hydroxide. The solution was filtered and evaporated in
vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a
creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from
licorice root.
Therapeutic Function
Antiinflammatory (gastric)
General Description
Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.
Biological Activity
Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.
storage
Store at +4°C
References
[1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.
[2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.
Carbenoxolone disodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbenoxolone disodium manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- Carbenoxolone disodium 7421-40-1
- Price
- US $1.00-1.00/Kg/Bag
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-30
Career Henan Chemical Co
- Product
- Carbenoxolone disodium 7421-40-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18
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