ChemicalBook > CAS DataBase List > Carbenoxolone disodium
Carbenoxolone disodium
- Product Name
- Carbenoxolone disodium
- CAS No.
- 7421-40-1
- Chemical Name
- Carbenoxolone disodium
- Synonyms
- neogel;sanodin;duogastrone;pyrogastrone;20-beta)-3-bet;ulcus-tablinen;sodiumcarbenoxolone;CARBENOXOLONE SODIUM;Carbenoxalone Sodium;Carbenoxolone disodi
- CBNumber
- CB3680281
- Molecular Formula
- C34H48Na2O7
- Formula Weight
- 614.72
- MOL File
- 7421-40-1.mol
More
Less
Carbenoxolone disodium Property
- Melting point:
- >275°C (dec.)
- storage temp.
- 2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- pKa1 4.18; pKa2 5.52(at 25℃)
- color
- White to Off-White
- Water Solubility
- Soluble in water to 100 mM.
- Stability:
- Hygroscopic
- LogP
- 7.083 (est)
- CAS DataBase Reference
- 7421-40-1(CAS DataBase Reference)
More
Less
More
Less
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C4790
- Product name
- Carbenoxolone disodium salt
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $54.3
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- C4790
- Product name
- Carbenoxolone disodium salt
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $226
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J63714
- Product name
- Carbenoxolone disodium salt, 97+%
- Packaging
- 1g
- Price
- $45.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J63714
- Product name
- Carbenoxolone disodium salt, 97+%
- Packaging
- 5g
- Price
- $191.65
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 18240
- Product name
- Carbenoxolone (sodium salt)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $38
- Updated
- 2024/03/01
More
Less
Carbenoxolone disodium Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Biogastrone,Winthrop,UK,1963
Uses
Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.
Uses
Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative
Uses
beta-adrenergic agonist, growth stimulant
Definition
ChEBI: Carbenoxolone sodium is a triterpenoid.
Manufacturing Process
23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution
of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by
30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry
pyridine. The solution was heated on a boiling water bath for ten hours and
then poured into excess of dilute hydrochloric acid and ice. The fine gray
precipitate formed was filtered off, washed with water, dissolved in chloroform,
and the solution repeatedly extracted with dilute hydrochloric acid and later
with water. It was dried over sodium sulfate and evaporated to dryness.
Crystallization from methanol, using charcoal to effect decolorization, gave the
hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with
previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was
ground with a dilute (5%) aqueous solution containing two molecular
proportions of sodium hydroxide. The solution was filtered and evaporated in
vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a
creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from
licorice root.
Therapeutic Function
Antiinflammatory (gastric)
General Description
Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.
Biological Activity
Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.
storage
Store at +4°C
References
[1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.
[2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.
Carbenoxolone disodium Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Carbenoxolone disodium Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94657
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 19951945301
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19185
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7787
- Advantage
- 56
- Tel
- 0898-66518050 13307521111
- Fax
- +86 (898) 6677-5768
- mfy001@hnmfy.com
- Country
- China
- ProdList
- 85
- Advantage
- 60
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 0572-2745768-1 13167223168
- Fax
- 13167223168
- sales@puripharm.com
- Country
- China
- ProdList
- 297
- Advantage
- 65
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27313
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20806
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-58180488
- Fax
- 021-58180499
- sales@Medchemleader.com
- Country
- China
- ProdList
- 1005
- Advantage
- 58
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15951
- Advantage
- 58
- Tel
- 021-58958002 18930822973
- Fax
- 021-58958618
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 1942
- Advantage
- 58
- Tel
- 0751-2815688 13927872512
- Fax
- 0751-8963795
- 3007421951@qq.com
- Country
- China
- ProdList
- 10056
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57423
- Advantage
- 58
- Tel
- +8618530059196
- sale04@alfachem.cn
- Country
- China
- ProdList
- 11915
- Advantage
- 58
- Tel
- +86 13288715578 +8613288715578
- sales@hbmojin.com
- Country
- China
- ProdList
- 12830
- Advantage
- 58
- Tel
- +86-0551-65418671 +8618949823763
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34563
- Advantage
- 58
- Tel
- 571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52849
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15352
- Advantage
- 58
- Tel
- +86-029-89586680 +86-18192503167
- Fax
- +86-29-88380327
- 1026@dideu.com
- Country
- China
- ProdList
- 7724
- Advantage
- 58
- Tel
- 15151934985
- sales@yingsapharm.com
- Country
- China
- ProdList
- 4360
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49476
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29809
- Advantage
- 58
- Tel
- +86-29-87569262 +86-15003564040
- Fax
- 029-88380327
- 1087@dideu.com
- Country
- China
- ProdList
- 3167
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 4297
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4195
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 18642120371
- 2837458851@qq.com
- Country
- China
- ProdList
- 7995
- Advantage
- 58
- Tel
- 027-59106051 13627137652
- Fax
- 027-59223020
- 1438180055@qq.com
- Country
- China
- ProdList
- 9880
- Advantage
- 58
- Tel
- 027-59322316 15172518801
- Fax
- 027-59322316
- 1208480077@qq.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4494
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 0319-5925599 13373390591
- Fax
- 0319 5925599
- 13933732699@163.com
- Country
- China
- ProdList
- 12185
- Advantage
- 58
- Tel
- 0319-5925599 13315915972
- 13313090628@163.com
- Country
- China
- ProdList
- 2916
- Advantage
- 58
- Tel
- 13774214275
- zhouzz@univ-bio.com
- Country
- China
- ProdList
- 24998
- Advantage
- 58
- Tel
- 13564510648
- Fax
- 021-54301252
- 2985380065@qq.com
- Country
- China
- ProdList
- 110
- Advantage
- 58
- Tel
- 0371-55969461； 0371-86658258 19139748274
- Fax
- QQ：3311217266
- info@kehobio.com
- Country
- China
- ProdList
- 2555
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62075
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 4001650900 13817534909
- 3003940895@qq.com
- Country
- China
- ProdList
- 10717
- Advantage
- 58
- Tel
- 0371-53370800 18037197114
- 2853031799@qq.com
- Country
- China
- ProdList
- 9968
- Advantage
- 58
- Tel
- 029-87576359 15353716720
- 1039@dideu.com
- Country
- China
- ProdList
- 10009
- Advantage
- 58
- Tel
- 021-021-59178156 15300768757
- 359382369@qq.com
- Country
- China
- ProdList
- 10674
- Advantage
- 58
- Tel
- 18327245847 18327245847
- 1400838877@qq.com
- Country
- China
- ProdList
- 9959
- Advantage
- 58
More
Less
View Lastest Price from Carbenoxolone disodium manufacturers
Hebei Mujin Biotechnology Co.,Ltd
- Product
- Carbenoxolone disodium 7421-40-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19
Shaanxi Dideu Medichem Co. Ltd
- Product
- Carbenoxolone disodium 7421-40-1
- Price
- US $1.00-1.00/Kg/Bag
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-30
Career Henan Chemical Co
- Product
- Carbenoxolone disodium 7421-40-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18
7421-40-1, Carbenoxolone disodiumRelated Search:
Sodium chlorite
Sodium formate
Sodium salicylate
Ethylenediaminetetraacetic acid disodium salt
Sodium gluconate
Trisodium citrate dihydrate
Sodium carbonate
Sodium silicate
Sodium percarbonate
Sodium benzoate
18β-Glycyrrhetinic Acid
Sodium Monofluorophosphate
Carbenoxolone
SODIUM CYCLOHEXANEBUTYRATE
LAURIC ACID SODIUM SALT
Sodium cyclohexanecarboxylate
3-Methyl-5-ethyl-2-cyclohexen-1-one
SODIUM 4-HYDROXYBUTYRATE