1,3-Diamino-2-propanol

Product Name: 1,3-Diamino-2-propanol
CAS No.: 616-29-5
Chemical Name: 1,3-Diamino-2-propanol
Synonyms: 1,3-DIAMINOPROPAN-2-OL;1,3-DIAMINO-2-HYDROXYPROPANE;Glycerol-α,γ-diamine;1,3-diamino-2-propano;1,3-DIAMINO-2-PROPANOL;2-Propanol, 1,3-diamino-;2-Hydroxypropylenediamine;1,3-Diamino-2-propanol>1,3-DIAMINO-2-HYDROXYPROPAN;1,3-Diamino-2-propanol ,97%
CBNumber: CB9315639
Molecular Formula: C3H10N2O
Formula Weight: 90.12
MOL File: 616-29-5.mol

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1,3-Diamino-2-propanol Property

Melting point:: 40-44 °C(lit.)
Boiling point:: 235°C
Density: 1.0352 (rough estimate)
refractive index: 1.4610 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: water: soluble1g/10 mL
form: Low Melting Solid
pka: 9.69, 7.93(at 20℃)
color: White to yellow
Water Solubility: Very soluble in water.
BRN: 741859
InChI: InChI=1S/C3H10N2O/c4-1-3(6)2-5/h3,6H,1-2,4-5H2
InChIKey: UYBWIEGTWASWSR-UHFFFAOYSA-N
SMILES: C(N)C(O)CN
CAS DataBase Reference: 616-29-5(CAS DataBase Reference)
EPA Substance Registry System: 2-Propanol, 1,3-diamino- (616-29-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
RIDADR: 3259
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29221990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33262
Product name: 1,3-Diamino-2-propanol
Purity: purum, ≥96.5% (GC)
Packaging: 5G
Price: $62.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 33262
Product name: 1,3-Diamino-2-propanol
Purity: purum, ≥96.5% (GC)
Packaging: 25g
Price: $158.2
Updated: 2025/07/31

TCI Chemical

Product number: H0497
Product name: 1,3-Diamino-2-propanol
Purity: >97.0%(T)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: H0497
Product name: 1,3-Diamino-2-propanol
Purity: >97.0%(T)
Packaging: 25g
Price: $104
Updated: 2025/07/31

Sigma-Aldrich

Product number: D18609
Product name: 1,3-Diamino-2-propanol
Purity: 95%
Packaging: 5g
Price: $49.7
Updated: 2025/07/31

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1,3-Diamino-2-propanol Chemical Properties,Usage,Production

Description

1,3-Diamino-2-propanol (DAP), also known as 2-hydroxy-1,3-diaminopropane, is a white to yellowish low melting solid. Keep in a cool, well-ventilated place. Avoid prolonged storage periods. Store under inert gas, in a tightly sealed container and at ambient temperatures. 1,3-Diamino-2-propanol is incompatible with acids and strong oxidizing agents and should not be stored or handled in their vicinity.

Chemical Properties

white to yellowish low melting solid

Uses

1,3-Diamino-2-propanol is a versatile bidentate diamine ligand which is used in the synthesis of a variety of organometallic compounds.
It is a precursor to synthesize the fluorogenic dsDNA binder, N¹,N³-bis(4-amidinophenyl)propane-1,3-diamine (BAPPA).
It can also be used as a branching unit in the synthesis of peptide dendrimers.

Application

1,3-diamino-2-propanol (DAPL), a close analog of 1,3-diaminopropane, is an indirect inhibitor of ornithine decarboxylase (ODC). It is administered orally and inhibits ODC activity in the livers of partially hepatectomized rats[1]. It contains amine and hydroxyl groups. Therefore, it can be crosslinked with the carboxyl group via covalent and hydrogen bonds and has been investigated as a diamine monomer in the aqueous phase to fabricate the high-performance RO membrane[2].

Preparation

1,3-Diamino-2-propanol is synthesized by reacting Epichlorohydrin with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.

Hazard

1,3-Diamino-2-propanoli is a hazardous chemical.
H302 (66.17%): Harmful if swallowed [Warning Acute toxicity, oral]. H314 (66.92%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]. H315 (33.08%): Causes skin irritation [Warning Skin corrosion/irritation]. H317 (66.17%): May cause an allergic skin reaction [Warning Sensitization, Skin]. H318 (66.17%): Causes serious eye damage [Danger Serious eye damage/eye irritation]. H319 (33.08%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]. H335 (34.59%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation.

Purification Methods

Dissolve it in an equal amount of water, shake it with charcoal and distil it at 68o/0.1mm. The distillate solidifies. It is too viscous to be distilled through a packed column. [Beilstein 4 IV 1694.]

References

[1] Raunio H, et al. The inhibition of induction of microsomal monooxygenase activity by 1,3-diamino-2-propanol, an inhibitor of ornithine decarboxylase. Biochemical and Biophysical Research Communications, 1979; 9: 285–290.
[2] Su T, et al. A novel polyamide thin-film nanocomposite reverse osmosis membrane constructed by a 3D multi-layer graphene oxide assembled with 1,3-diamino-2-propanol. Journal of Membrane Science, 2023; 681: 121773.

1,3-Diamino-2-propanol Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 1,3-Diamino-2-propanol manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 1,3-Diamino-2-propanol 616-29-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-21

Shaanxi Xianhe Biotech Co., Ltd

Product: 1,3-Diamino-2-hydroxypropane 616-29-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000KG
Release date: 2025-04-22

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1,3-Diamino-2-propanol 616-29-5
Price: US $99.00-45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-12-05

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616-29-5 L59259H635 1,3-Diamino-2-propanol 1,3-Diaminopropan-2-ol 2-Propanol, 1,3-diamino- AI3-15325 1,3-Diamino-2-hydroxypropane Diaminoisopropanol EINECS 210-474-2 2-Hydroxy-1,3-diaminoprop

616-29-5 L59259H635 1,3-Diamino-2-propanol 1,3-Diaminopropan-2-ol 2-Propanol, 1,3-diamino- AI3-15325 1,3-Diamino-2-hydroxypropane Diaminoisopropanol EINECS 210-474-2 2-Hydroxy-1,3-diaminopropane 2-Hydroxy-1,3-propanediamine NSC 6070 UNII-L59259H635 EC 210-474-2

1.3-Diamino-2-hydroxypropane1

616-29-5

NH2CH2CHOHCH2NH2

C3H10N2O1

C3H10N2O

C3H12N2O

Oxygen Compounds

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