EFONIDIPINE
- Product Name
- EFONIDIPINE
- CAS No.
- 111011-76-8
- Chemical Name
- EFONIDIPINE
- Synonyms
- nz-105;nz105ethanolate;Hydrochloride ethanol;EFONIDIPINE USP/EP/BP;r,p-oxide,monohydrochloride;efonidipinehydrochlorideethanolate;NZ-105 HYDROCHLORIDE MONOETHANOLATE;2-(phenyl(phenylmethyl)amino)ethyleste;Efonidipine hydrochloride monoethanolate;Efonidipine Hydrochloride ethanol (1:1:1)
- CBNumber
- CB9317820
- Molecular Formula
- C34H38N3O7P
- Formula Weight
- 631.66
- MOL File
- 111011-76-8.mol
EFONIDIPINE Property
- Melting point:
- 151° (dec)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO : 25 mg/mL (35.01 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E0159
- Product name
- Efonidipine hydrochloride monoethanolate
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $100
- Updated
- 2024/03/01
- Product number
- E0159
- Product name
- Efonidipine hydrochloride monoethanolate
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $381
- Updated
- 2024/03/01
- Product number
- 255225
- Product name
- Efonidipine hydrochloride monoethanolate
- Packaging
- 10mg
- Price
- $366
- Updated
- 2021/12/16
- Product number
- CS-3622
- Product name
- Efonidipinehydrochloridemonoethanolate
- Purity
- 99.83%
- Packaging
- 10mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- U165
- Product name
- Efonidipinehydrochloridemonoethanolate
- Packaging
- 10mg
- Price
- $56
- Updated
- 2021/12/16
EFONIDIPINE Chemical Properties,Usage,Production
Description
Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP) calcium channel blocker to reach the market, it functions by binding to the DHP receptors on voltage-dependent calcium channels to cause diuretic and natriuretic actions in patients with essential hypertension. Its vasodilating and calcium antagonist effects are very slow in onset and long-lasting in all types of experimentally hypertensive models and the agent is reported to exhibit an improved side effect profile compared with other drugs of the same class. This may be explained by the slow and long-lasting inhibition of transmembrane Ca+2 uptake, which is accompanied by its very slow binding to and dissociation from the DHP receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may suppress the development of atherosclerosis without affecting the plasma lipids. Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been reported.
Originator
Nissan Chemical (Japan)
Uses
Efonidipine Hydrochloride Monoethanolate is a potent inhibitor of the L-type calcium channel.
Definition
ChEBI: Efonidipine hydrochloride is a dihydropyridine.
brand name
Landel
Biological Activity
Selective blocker of L-type and T-type Ca 2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R (-) and S (+)-enantiomers displays different channel selectivity; S (+)-Efonidipine blocks L-type and T-type channels whereas R (-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.
EFONIDIPINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from EFONIDIPINE manufacturers
- Product
- Efonidipine 111011-76-8
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-07
- Product
- EFONIDIPINE 111011-76-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-06
- Product
- Efonidipine 111011-76-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11