ChemicalBook > CAS DataBase List > EFONIDIPINE

EFONIDIPINE

Product Name
EFONIDIPINE
CAS No.
111011-76-8
Chemical Name
EFONIDIPINE
Synonyms
nz-105;nz105ethanolate;Hydrochloride ethanol;EFONIDIPINE USP/EP/BP;r,p-oxide,monohydrochloride;efonidipinehydrochlorideethanolate;NZ-105 HYDROCHLORIDE MONOETHANOLATE;2-(phenyl(phenylmethyl)amino)ethyleste;Efonidipine hydrochloride monoethanolate;Efonidipine Hydrochloride ethanol (1:1:1)
CBNumber
CB9317820
Molecular Formula
C34H38N3O7P
Formula Weight
631.66
MOL File
111011-76-8.mol
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EFONIDIPINE Property

Melting point:
151° (dec)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO : 25 mg/mL (35.01 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E0159
Product name
Efonidipine hydrochloride monoethanolate
Purity
≥98% (HPLC)
Packaging
5MG
Price
$100
Updated
2024/03/01
Sigma-Aldrich
Product number
E0159
Product name
Efonidipine hydrochloride monoethanolate
Purity
≥98% (HPLC)
Packaging
25MG
Price
$381
Updated
2024/03/01
Usbiological
Product number
255225
Product name
Efonidipine hydrochloride monoethanolate
Packaging
10mg
Price
$366
Updated
2021/12/16
ChemScene
Product number
CS-3622
Product name
Efonidipinehydrochloridemonoethanolate
Purity
99.83%
Packaging
10mg
Price
$96
Updated
2021/12/16
AK Scientific
Product number
U165
Product name
Efonidipinehydrochloridemonoethanolate
Packaging
10mg
Price
$56
Updated
2021/12/16
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EFONIDIPINE Chemical Properties,Usage,Production

Description

Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP) calcium channel blocker to reach the market, it functions by binding to the DHP receptors on voltage-dependent calcium channels to cause diuretic and natriuretic actions in patients with essential hypertension. Its vasodilating and calcium antagonist effects are very slow in onset and long-lasting in all types of experimentally hypertensive models and the agent is reported to exhibit an improved side effect profile compared with other drugs of the same class. This may be explained by the slow and long-lasting inhibition of transmembrane Ca+2 uptake, which is accompanied by its very slow binding to and dissociation from the DHP receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may suppress the development of atherosclerosis without affecting the plasma lipids. Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been reported.

Originator

Nissan Chemical (Japan)

Uses

Efonidipine Hydrochloride Monoethanolate is a potent inhibitor of the L-type calcium channel.

Definition

ChEBI: Efonidipine hydrochloride is a dihydropyridine.

brand name

Landel

Biological Activity

Selective blocker of L-type and T-type Ca 2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R (-) and S (+)-enantiomers displays different channel selectivity; S (+)-Efonidipine blocks L-type and T-type channels whereas R (-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

EFONIDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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EFONIDIPINE Suppliers

China 63 Germany 1 India 5 United Kingdom 3 United States 15 Global 87
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View Lastest Price from EFONIDIPINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Efonidipine 111011-76-8
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-07
Dideu Industries Group Limited
Product
EFONIDIPINE 111011-76-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-06
Shaanxi Dideu Medichem Co. Ltd
Product
Efonidipine 111011-76-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

111011-76-8, EFONIDIPINERelated Search:

Isosorbide dinitrate

  • Efonidipine hydrochloride monoethanolate
  • Efonidipine Hydrochloride ethanol (1:1:1)
  • 2-(phenyl(phenylmethyl)amino)ethyleste
  • 3-pyridinecarboxylicacid,1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-1,3,2-dioxa
  • efonidipinehydrochlorideethanolate
  • nz-105
  • nz105ethanolate
  • NZ-105 HYDROCHLORIDE MONOETHANOLATE
  • r,p-oxide,monohydrochloride
  • 5-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylicacid2-[phenyl(phenylmethyl)amino]ethylesterhydrochloridemonoethanolate
  • Hydrochloride ethanol
  • EFONIDIPINE USP/EP/BP
  • Ethanol, compd. with 2-(phenyl(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate P-oxide monohydrochloride (1:1)
  • 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate compound with ethanol (1:1) hydrochloride
  • 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride
  • inhibit,Efonidipine hydrochloride monoethanolate,Ca channels,Ca2+ channels,Calcium Channel,Inhibitor
  • 111011-76-8
  • C34H38N3O7P
  • C34H38N3O7PHClC2H5OH