EFONIDIPINE

Product Name: EFONIDIPINE
CAS No.: 111011-76-8
Chemical Name: EFONIDIPINE
Synonyms: nz-105;nz105ethanolate;Hydrochloride ethanol;EFONIDIPINE USP/EP/BP;r,p-oxide,monohydrochloride;efonidipinehydrochlorideethanolate;NZ-105 HYDROCHLORIDE MONOETHANOLATE;2-(phenyl(phenylmethyl)amino)ethyleste;Efonidipine hydrochloride monoethanolate;Efonidipine Hydrochloride ethanol (1:1:1)
CBNumber: CB9317820
Molecular Formula: C34H38N3O7P.C2H6O.ClH
Formula Weight: 714.19
MOL File: 111011-76-8.mol

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EFONIDIPINE Property

Melting point:: 151° (dec)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO : 25 mg/mL (35.01 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E0159
Product name: Efonidipine hydrochloride monoethanolate
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: E0159
Product name: Efonidipine hydrochloride monoethanolate
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $381
Updated: 2024/03/01

Usbiological

Product number: 255225
Product name: Efonidipine hydrochloride monoethanolate
Packaging: 10mg
Price: $366
Updated: 2021/12/16

AK Scientific

Product number: U165
Product name: Efonidipinehydrochloridemonoethanolate
Packaging: 10mg
Price: $56
Updated: 2021/12/16

ChemScene

Product number: CS-3622
Product name: Efonidipinehydrochloridemonoethanolate
Purity: 99.83%
Packaging: 10mg
Price: $96
Updated: 2021/12/16

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EFONIDIPINE Chemical Properties,Usage,Production

Description

Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP) calcium channel blocker to reach the market, it functions by binding to the DHP receptors on voltage-dependent calcium channels to cause diuretic and natriuretic actions in patients with essential hypertension. Its vasodilating and calcium antagonist effects are very slow in onset and long-lasting in all types of experimentally hypertensive models and the agent is reported to exhibit an improved side effect profile compared with other drugs of the same class. This may be explained by the slow and long-lasting inhibition of transmembrane Ca⁺² uptake, which is accompanied by its very slow binding to and dissociation from the DHP receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may suppress the development of atherosclerosis without affecting the plasma lipids. Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been reported.

Originator

Nissan Chemical (Japan)

Uses

Efonidipine Hydrochloride Monoethanolate is a potent inhibitor of the L-type calcium channel.

Definition

ChEBI: Efonidipine hydrochloride is a dihydropyridine.

brand name

Landel

Biological Activity

Selective blocker of L-type and T-type Ca 2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R (-) and S (+)-enantiomers displays different channel selectivity; S (+)-Efonidipine blocks L-type and T-type channels whereas R (-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

EFONIDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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EFONIDIPINE Suppliers

China 65 Germany 1 India 5 United Kingdom 3 United States 16 Global 90

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-18601685-898 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2773
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4668
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Taizhou Ruixin Chemical Co., Ltd.

Tel: 0576-89085261 15867635987
Fax: 0576-89085262
Email: jasonhu09@163.com
Country: China
ProdList: 442
Advantage: 50

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View Lastest Price from EFONIDIPINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Efonidipine 111011-76-8
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-07

Shaanxi Dideu Medichem Co. Ltd

Product: Efonidipine 111011-76-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

111011-76-8, EFONIDIPINERelated Search:

Isosorbide dinitrate

Efonidipine hydrochloride monoethanolate

Efonidipine Hydrochloride ethanol (1:1:1)

2-(phenyl(phenylmethyl)amino)ethyleste

3-pyridinecarboxylicacid,1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-1,3,2-dioxa

efonidipinehydrochlorideethanolate

nz-105

nz105ethanolate

NZ-105 HYDROCHLORIDE MONOETHANOLATE

r,p-oxide,monohydrochloride

5-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylicacid2-[phenyl(phenylmethyl)amino]ethylesterhydrochloridemonoethanolate

Hydrochloride ethanol

EFONIDIPINE USP/EP/BP

Ethanol, compd. with 2-(phenyl(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate P-oxide monohydrochloride (1:1)

2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate compound with ethanol (1:1) hydrochloride

2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride

inhibit,Efonidipine hydrochloride monoethanolate,Ca channels,Ca2+ channels,Calcium Channel,Inhibitor

3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride, compd. with ethanol (1:1:1)

111011-76-8

C34H38N3O7P

C34H38N3O7PHClC2H5OH