(S)-(+)-2-Amino-3-methyl-1-butanol

ChemicalBook > CAS DataBase List > (S)-(+)-2-Amino-3-methyl-1-butanol

(S)-(+)-2-Amino-3-methyl-1-butanol

Product Name: (S)-(+)-2-Amino-3-methyl-1-butanol
CAS No.: 2026-48-4
Chemical Name: (S)-(+)-2-Amino-3-methyl-1-butanol
Synonyms: L-VALINOL;L-VALINAL;S-VALINOL;H-VAL-OL;l-2-amino-3-methylbutan-1-ol;L-2-AMINO-3-METHYL-1-BUTANOL;(S)-2-AMINO-3-METHYL-1-BUTANOL;M0;val-ol;L-Valino
CBNumber: CB9319657
Molecular Formula: C5H13NO
Formula Weight: 103.16
MOL File: 2026-48-4.mol

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(S)-(+)-2-Amino-3-methyl-1-butanol Property

Melting point:: 30-34 °C
Boiling point:: 81 °C8 mm Hg(lit.)
alpha: 16 º (c=10,EtOH)
Density: 0.926 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4548(lit.)
Flash point:: 196 °F
storage temp.: Store at +2°C to +8°C.
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.82±0.10(Predicted)
form: Liquid After Melting
color: Clear slightly yellow
optical activity: [α]25/D +10°, c = 10 in H2O
Water Solubility: Soluble in water.
Sensitive: Air Sensitive
BRN: 1719137
InChIKey: NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS DataBase Reference: 2026-48-4(CAS DataBase Reference)
NIST Chemistry Reference: (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36-36/37/38
Safety Statements: 26-24/25-36
WGK Germany: 3
F: 10-23
HazardClass: IRRITANT
HS Code: 29221980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 186708
Product name: (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: 96%
Packaging: 1g
Price: $54.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 186708
Product name: (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: 96%
Packaging: 5g
Price: $88
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14082
Product name: (S)-(+)-2-Amino-3-methyl-1-butanol
Purity: for synthesis
Packaging: 1mL
Price: $12.3
Updated: 2024/03/01

TCI Chemical

Product number: V0058
Product name: L-Valinol
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $99
Updated: 2024/03/01

TCI Chemical

Product number: V0058
Product name: L-Valinol
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $297
Updated: 2024/03/01

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(S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.

Uses

(S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare:

Imines and oxazolines by reacting with aldehydes and nitriles, respectively.
Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety.

Purification Methods

Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]

(S)-(+)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-2-Amino-3-methyl-1-butanol Suppliers

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View Lastest Price from (S)-(+)-2-Amino-3-methyl-1-butanol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: L-Val-OL 2026-48-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-20

Henan Fengda Chemical Co., Ltd

Product: (S)-(+)-2-Amino-3-methyl-1-butanol 2026-48-4
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-22

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-(+)-2-Amino-3-methyl-1-butanol 2026-48-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

2026-48-4, (S)-(+)-2-Amino-3-methyl-1-butanolRelated Search:

3-Aminophenol Ketorolac tromethamine Fosfomycin tromethamine 3-Methyl-1-butanol 1-Butanol Glycine (R)-TERT-LEUCINOL Methylparaben Kresoxim-methyl VALINOMYCIN Bensulfuron methyl Methyl acrylate ALTRENOGEST 6-Aminocaproic acid tert-Butanol Thiophanate-methyl TRISTEARIN Dexketoprofen trometamol

L-VALINAL

(+)-L-VALINOL

L-(+)-VALINOL

L-VALINOL

L-2-AMINO-3-METHYL-1-BUTANOL

l-2-amino-3-methylbutan-1-ol

H-VALINOL

H-VAL-OL

H-L-VAL-OL

(2S)-2-AMINO-3-METHYL-BUTAN-1-OL

L-Valinol ,98%

(S)-2-Isopropyl-2-aminoethanol

(S)-(+)-2-Amino-3-methyl-1-butanol,96%

L-Valinol ,98% [ee: 95%]

L-Valinol ,95%

(S)-(+)-2-Amino-3-me

L-Valino

(S)-(+)-2-AMino-3-Methyl-1-butanol, 96% 1ML

(S)-(+)-2-AMINO-3-METHYL-1-BUTANOL FOR S

(S)-(+)-2-Amino-3-methyl-1-butanol(L-Valinal)

L-Valinol, 98%, ee: 95%

PKC PharMaceuticals, Inc.

L - valerian aMMonia alcohol

L-(+)-Valinol (S)-(+)-2-Amino-3-methyl-1-butanol L-2-Amino-3-methylbutan-1-ol

(S)-(+)-2-Amino-3-methyl-1-butanol 96%

L-Valinol Free Base

L-Valinol, ee: 95%

L-Valinol≥ 98% (GC)

L-Valinol,99%e.e.

L-Valinol,Elvitegravir intermediate

1-Butanol, 2-amino-3-methyl-, (S)-

(S)-(+)-2-Amino-3-methyl-1-butanol~H-Val-ol

Valinol,97%

(R)-(+)-2-Amino-3-methyl-1-butanolL-Valanol

L-Valinol(S)-(+)-2-Amino-3-methyl-1-butanol

L-Valanol

(S)-(+)-2-AMINO-3-METHYL-1-BUTANOL, 96% (95% EE/GLC)

L-Val-ol

(S)-2-AMINO-3-METHYL-1-BUTANOL 98.0%

1-Butanol, 2-amino-3-methyl-, (2S)-

S-VALINOL

(S)-2-AMINO-3-METHYL-L-BUTANOL

(S)-(+)-2-AMINO-3-METHYL-BUTANOL

(S)-2-AMINO-3-METHYL-BUTAN-1-OL

(S)-(+)-2-AMINO-3-METHYL-1-BUTANOL

(S)-2-AMINO-3-METHYL-1-BUTANOL

S-(-)-2-AMINO-3-METHYL-1-BUTANOL

H-Val-ol (S)-(+)-2-Amino-3-methyl-1-butanol)

-(+)-VaL

(S)-(+)-2-Amino-3-methyl-1-butanol USP/EP/BP

AMG-232-008

(+)-Valinol

val-ol

L-2-Amino-3-methyl-1-butanol, L-Valinol

2026-48-4

2046-48-4

226-48-4