2-Hydroxy-5-trifluoromethylpyridine
- Product Name
- 2-Hydroxy-5-trifluoromethylpyridine
- CAS No.
- 33252-63-0
- Chemical Name
- 2-Hydroxy-5-trifluoromethylpyridine
- Synonyms
- 2-Hydroxy-5-(t;BUTTPARK 24\01-67;Fampridine Impurity 216;5-Trifluoromethyl-Pyridin-2-;Hydroxy-5-(trifluoroMethyl)pyr;5-Trifluoromethyl-pyridin-2-ol;5-(Trifluoromethyl)-2-pyridone;5-(TRIFLUOROMETHYL)-2-PYRIDINOL;5-(Trifluoromethyl)pyridin-2-one;5-(Trifluoromethyl)-2-pyridinone
- CBNumber
- CB9321836
- Molecular Formula
- C6H4F3NO
- Formula Weight
- 163.1
- MOL File
- 33252-63-0.mol
2-Hydroxy-5-trifluoromethylpyridine Property
- Melting point:
- 145-149 °C (lit.)
- Boiling point:
- 221.2±40.0 °C(Predicted)
- Density
- 1.398±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Soluble), Ethanol (Sparingly), Methanol (Sightly)
- pka
- 9.55±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to beige
- InChI
- InChI=1S/C6H4F3NO/c7-6(8,9)4-1-2-5(11)10-3-4/h1-3H,(H,10,11)
- InChIKey
- BYRJSCNPUHYZQE-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(C(F)(F)F)C=C1
- CAS DataBase Reference
- 33252-63-0(CAS DataBase Reference)
- EPA Substance Registry System
- 2(1H)-Pyridinone, 5-(trifluoromethyl)- (33252-63-0)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-65-20/21/22-20/21
- Safety Statements
- 26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 442801
- Product name
- 2-Hydroxy-5-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 5G
- Price
- $53.56
- Updated
- 2025/07/31
- Product number
- T2539
- Product name
- 5-(Trifluoromethyl)-2-pyridone
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- T2539
- Product name
- 5-(Trifluoromethyl)-2-pyridone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $131
- Updated
- 2025/07/31
- Product number
- H971570
- Product name
- 2-Hydroxy-5-(trifluoromethyl)pyridine
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- JK388533
- Product name
- 2-Hydroxy-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $53
- Updated
- 2021/12/16
2-Hydroxy-5-trifluoromethylpyridine Chemical Properties,Usage,Production
Chemical Properties
Yellow to brown powder
Uses
2-Hydroxy-5-(trifluoromethyl)pyridine (cas# 33252-63-0) is a compound useful in organic synthesis.
General Description
2-Hydroxy-5-(trifluoromethyl)pyridine, a pyridine derivative, is a heterocyclic building block. They have useful applications in catalysis, drug design, molecular recognition, and natural product synthesis.
Synthesis
5006-66-6
33252-63-0
General procedure for the synthesis of 2-hydroxy-5-trifluoromethylpyridine from 6-hydroxynicotinic acid: 6-hydroxynicotinic acid (18.2 g, 0.13 mol), anhydrous hydrofluoric acid (2.6 mL, 0.13 mol, ≥95 wt%) and sulfur tetrafluoride (42.1 g, 0.39 mol) were added to a stainless steel pressure tank. The mixture was heated to 100 °C and reacted at 0.15 MPa pressure for 12 hours. The gaseous product generated during the reaction was treated by an exhaust gas absorption unit. Upon completion of the reaction, the remaining product was transferred to a polytetrafluoroethylene vessel and heated to 40°C to remove residual hydrogen fluoride. Subsequently, the product was dissolved in 150 mL of water and the pH was adjusted to 6.8-7.2 with saturated sodium carbonate solution. the aqueous phase was extracted with chloroform, and the organic phases were combined and dried. After filtration and drying, 2-hydroxy-5-trifluoromethylpyridine (15.3 g, 0.094 mol) was obtained in 72% yield.
References
[1] Patent: CN102875453, 2016, B. Location in patent: Paragraph 0023
2-Hydroxy-5-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Hydroxy-5-trifluoromethylpyridine manufacturers
- Product
- 2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE 33252-63-0
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Hydroxy-5-trifluoromethylpyridine 33252-63-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 2-Hydroxy-5-trifluoromethylpyridine 33252-63-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-20