Butanedioic acid, methylene-, 4-octyl ester
- Product Name
- Butanedioic acid, methylene-, 4-octyl ester
- CAS No.
- 3133-16-2
- Chemical Name
- Butanedioic acid, methylene-, 4-octyl ester
- Synonyms
- Itaconate;4-Octyl itaconate;Monooctyl Itaconate;itaconate(CTK1B2911);4-Octyl itaconate(CTK1B2911);4-Octyl itaconate >=98% (HPLC);4-Octyl itaconate, 10 mM in DMSO;2-Methylenebutanedioic acid 4-octyl ester;Butanedioic acid, methylene-, 4-octyl ester;2-Methylene-4-(octyloxy)-4-oxobutanoic acid
- CBNumber
- CB93223447
- Molecular Formula
- C13H22O4
- Formula Weight
- 242.32
- MOL File
- 3133-16-2.mol
Butanedioic acid, methylene-, 4-octyl ester Property
- Boiling point:
- 377.2±25.0 °C(Predicted)
- Density
- 1.026±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
- form
- A crystalline solid
- pka
- 3.84±0.11(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 25374
- Product name
- 4-octyl Itaconate
- Purity
- ≥98% (mixture of tautomers)
- Packaging
- 50mg
- Price
- $76
- Updated
- 2024/03/01
- Product number
- 25374
- Product name
- 4-octyl Itaconate
- Purity
- ≥98% (mixture of tautomers)
- Packaging
- 100mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- 25374
- Product name
- 4-octyl Itaconate
- Packaging
- 25mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 25374
- Product name
- 4-octyl Itaconate
- Purity
- ≥98% (mixture of tautomers)
- Packaging
- 250mg
- Price
- $292
- Updated
- 2024/03/01
- Product number
- 6662
- Product name
- 4-Octylitaconate
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $225
- Updated
- 2021/12/16
Butanedioic acid, methylene-, 4-octyl ester Chemical Properties,Usage,Production
Uses
4-Octyl Itaconate increases nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.
Biological Activity
4-Octyl itaconate (4-OI) possesses anti-inflammatory effects. It can obstruct glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and glycolysis in macrophages. It can be a good substitute to itaconate due to its thiol reactivity. The electrophilic α and β-unsaturated moieties of 4-OI might help to alkylate the thiol in cysteine residues of proteins through Michael reaction.', 'The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function. 4-Octyl itaconate is a cell-permeable itaconate derivative th at decreases cytokine production and is protective against lipopolysaccharide-induced lethality in vivo. Esterases in mouse myoblast cells and macrophages hydrolyze it to itaconate, which alkylates cysteine residues on KEAP1, allowing the transcription factor Nrf2 to increase the expression of anti-oxidant and anti-inflammatory downstream genes.
storage
Store at -20°C
Butanedioic acid, methylene-, 4-octyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Butanedioic acid, methylene-, 4-octyl ester Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from Butanedioic acid, methylene-, 4-octyl ester manufacturers
- Product
- Butanedioic acid, methylene-, 4-octyl ester 3133-16-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-07
- Product
- Butanedioic acid, methylene-, 4-octyl ester 3133-16-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25