LYN-1604
- Product Name
- LYN-1604
- CAS No.
- 2088939-99-3
- Chemical Name
- LYN-1604
- Synonyms
- CS-2635;CS-2610;LYN-1604;LYN-1604 Hcl;LYN-1604 2HCl;LYN1604;LYN 1604;LYN-1604;LYN 1604;LYN1604;1-(4-(2-(2,4-Dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl)piperazin-1-yl)-2-(diisobutylamino)ethanone , LYN-1604;Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-
- CBNumber
- CB93353955
- Molecular Formula
- C33H43Cl2N3O2
- Formula Weight
- 584.62
- MOL File
- 2088939-99-3.mol
LYN-1604 Property
- Boiling point:
- 670.9±55.0 °C(Predicted)
- Density
- 1.168±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 8.03±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 24007
- Product name
- LYN-1604
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 24007
- Product name
- LYN-1604
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $317
- Updated
- 2024/03/01
- Product number
- 24007
- Product name
- LYN-1604
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $593
- Updated
- 2024/03/01
- Product number
- 2413EL
- Product name
- CID131801113
- Packaging
- 1mg
- Price
- $187
- Updated
- 2021/12/16
- Product number
- CSN21387
- Product name
- LYN-1604
- Packaging
- 10mg
- Price
- $237
- Updated
- 2021/12/16
LYN-1604 Chemical Properties,Usage,Production
Description
LYN-1604 is an activator of unc-51-like kinase 1 (ULK1; EC50 = 18.94 nM). It increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 triple-negative breast cancer (TNBC) cells in a concentration-dependent manner, indicating an increase in autophagy. It also increases the cleavage of the pro-apoptotic protein caspase-3. LYN-1604 decreases the viability of MDA-MB-231 cells in vitro (IC50 = 1.66 μM), an effect that can be reversed by the autophagy inhibitor 3-methyladenine (3-MA; ). LYN-1604 (25, 50, and 100 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model.
LYN-1604 Preparation Products And Raw materials
Raw materials
Preparation Products
LYN-1604 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
- 2738
- Advantage
- 58
- Tel
- +8613564774135
- zijue.cai@tsbiochem.com
- Country
- United States
- ProdList
- 19885
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38631
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
View Lastest Price from LYN-1604 manufacturers
- Product
- LYN-1604 2088939-99-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29