ChemicalBook > CAS DataBase List > 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE

1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE

Product Name
1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE
CAS No.
14150-94-8
Chemical Name
1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE
Synonyms
1-Methyl-3,5-dinitropyridin-2(1H)-one;1-Methyl-3,5-dinitro-2-pyridone;Atogepant Impurity 14;1-Methyl-3,5-dinitro-1H-p...;1-Methyl-3,5-dinitropyridine-2;3,5-Dinitro-1-methyl-2-pyridone;1-Methyl-3,5-dinitro-2-pyridine;1-Methyl-3,5-dinitro-2-pyridinone;1-METHYL-3,5-DINITROPYRIDIN-2-ONE;1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE
CBNumber
CB9352014
Molecular Formula
C6H5N3O5
Formula Weight
199.12
MOL File
14150-94-8.mol
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1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE Property

Melting point:
174-178℃
Boiling point:
289.5±40.0 °C(Predicted)
Density 
1.60
storage temp. 
Store at 0-8℃
pka
-8.36±0.62(Predicted)
form 
powder to crystal
color 
Light orange to Yellow to Green
λmax
308nm(H2O)(lit.)
InChI
InChI=1S/C6H5N3O5/c1-7-3-4(8(11)12)2-5(6(7)10)9(13)14/h2-3H,1H3
InChIKey
QARVELJVEBLWGK-UHFFFAOYSA-N
SMILES
C1(=O)N(C)C=C([N+]([O-])=O)C=C1[N+]([O-])=O
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
680885
Product name
1-Methyl-3,5-dinitropyridin-2(1H)-one
Purity
97%
Packaging
1g
Price
$83.2
Updated
2023/06/20
TCI Chemical
Product number
M2820
Product name
1-Methyl-3,5-dinitro-2-pyridone
Purity
>98.0%(GC)
Packaging
1g
Price
$71
Updated
2025/07/31
Usbiological
Product number
284067
Product name
1-Methyl-3,5-dinitro-1H-pyridin-2-one
Packaging
500mg
Price
$333
Updated
2021/12/16
TRC
Product number
M218858
Product name
1-Methyl-3,5-dinitro-1H-pyridin-2-one
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
M218858
Product name
1-Methyl-3,5-dinitro-1H-pyridin-2-one
Packaging
50mg
Price
$60
Updated
2021/12/16
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1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE Chemical Properties,Usage,Production

Uses

1-Methyl-3,5-dinitro-1H-pyridin-2-one can be used as an organic synthesis intermediate involved in the efficient synthesis of nitrocyclic ether[b]pyridine. It is also a nucleophilic reagent. It reacts with primary amines to produce carbamates in an efficient way without using reducing agents. The electronic defects of the pyridine cation allow this nucleophilic attack.

Synthesis

694-85-9

14150-94-8

General procedure for the synthesis of 1-methyl-3,5-dinitro-1H-pyridin-2-one from 1-methyl-2-pyridone: To a stirred mixture of 1-methyl-2-pyridone (33.47 g, 0.306 mol) and concentrated sulfuric acid (300 mL) was added concentrated nitric acid (120 mL) in batches at 100 °C. The reaction mixture was heated at this temperature overnight and then poured into ice (1400 mL). The precipitate was collected by filtration and washed with water to afford 1-methyl-3,5-dinitro-1H-pyridin-2-one (yield: 18.66 g, 30%).1H NMR (400 MHz, CDCl3): δ 9.05 (d, 1H), 8.90 (d, 1H), 3.80 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5392 - 5397
[2] Patent: WO2004/69832, 2004, A2. Location in patent: Page 137-138
[3] Patent: US2011/98311, 2011, A1
[4] Patent: US2012/309758, 2012, A1
[5] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0698

1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE Suppliers

Americas 1 China 129 Europe 1 India 2 Japan 1 United Kingdom 1 United States 16 Global 151
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE manufacturers

Hpets Biotech Company (Chongqing) Co.,ltd
Product
1-Methyl-3,5-dinitropyridin-2(1H)-one 14150-94-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-03-23
Honest Joy Holdings Limited
Product
1-Methyl-3,5-dinitro-1H-pyridin-2-one 14150-94-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.9%
Supply Ability
100 tons
Release date
2022-01-26
Dideu Industries Group Limited
Product
1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE 14150-94-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26

14150-94-8, 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONERelated Search:

Pyridine Tosyl chloride 2-Cyanopyridine 3-Nitro-2-pyridinol 5-AMINO-1-METHYLPYRIDIN-2(1H)-ONE 2-HYDROXY-3,5-DINITROPYRIDINE 5-NITRO-1-METHYL-2(1H)-PYRIDINONE 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE

  • 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE
  • 2(1H)-Pyridinone, 1-methyl-3,5-dinitro-
  • 1-Methyl-3,5-dinitropyridin-2(1H)-one
  • 1-Methyl-3,5-dinitro-1,2-dihydropyridine-2-one
  • 3,5-Dinitro-1-methyl-2-pyridone
  • 1-Methyl-3,5-dinitropyridine-2
  • 1-Methyl-3,5-dinitro-1H-p...
  • 1-Methyl-3,5-dinitropyridine-2(1H)-one
  • 1-Methyl-3,5-dinitro-2-pyridone
  • 1-Methyl-3,5-dinitro-1,2-dihydropyridin-2-one
  • 1-<WBR>Methyl-<WBR>3,5-<WBR>dinitropyridin-<WBR>2(1<I>H</I>)-one
  • 1-Methyl-3,5-dinitro-2-pyridinone
  • 1-Methyl-3,5-dinitropyridin-2(1H)-one 97%
  • 1-Methyl-3,5-dinitropyridin-2(1<I>H</I>)-one
  • 1-METHYL-3,5-DINITROPYRIDIN-2-ONE
  • 1-methyl-3,5-dinitro-2(1H)-Pyridinone
  • 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE ISO 9001：2015 REACH
  • 1-Methyl-3,5-dinitro-2-pyridine
  • Atogepant Impurity 14
  • 14150-94-8
  • Pyridines
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Heterocycle-Pyridine series
  • C6