ChemicalBook > CAS DataBase List > SR-95531

SR-95531

Product Name
SR-95531
CAS No.
104104-50-9
Chemical Name
SR-95531
Synonyms
GABAZINE;SR-95531;SR-95531【S106】;GABAZINE BROMIDE;SR 95531 hydrobromid;Gabazine Hydrobromide;SR 95531 HYDROBROMIDE;Gabazine, 10 mM in DMSO;SR 95531 hydrobromide NEW;Gabazine bromide (SR95531)
CBNumber
CB9356638
Molecular Formula
C15H18BrN3O3
Formula Weight
368.23
MOL File
104104-50-9.mol
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SR-95531 Property

Melting point:
200 °C(Solv: ethanol (64-17-5))
storage temp. 
Store at RT
solubility 
DMSO: 30 mg/mL
form 
solid
color 
white
Water Solubility 
water: 25mM
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S106
Product name
SR-95531
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$662
Updated
2025/07/31
Sigma-Aldrich
Product number
5.05986
Product name
SR95531 (Gabazine) - CAS 104104-50-9 - Calbiochem
Packaging
10mg
Price
$160
Updated
2025/07/31
Cayman Chemical
Product number
14585
Product name
SR 95531 (hydrobromide)
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
14585
Product name
SR 95531 (hydrobromide)
Purity
≥98%
Packaging
10mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
S106
Product name
SR-95531
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$196
Updated
2025/07/31
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SR-95531 Chemical Properties,Usage,Production

Description

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABAA receptors (Ki = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABAA receptor isoforms from mice, rats, and humans.

Uses

Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.

Biological Activity

Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

storage

Room temperature

References

[1] MICHEL HEAULME . Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site[J]. Brain Research, 1986, 384 2: Pages 224-231. DOI: 10.1016/0006-8993(86)91158-3
[2] ANITA MELIKIAN. Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists[J]. Journal of Medicinal Chemistry, 1992, 35 22: 4092-4097. DOI: 10.1021/jm00100a015
[3] DORTE KREHAN. Potent 4-Arylalkyl-Substituted 3-Isothiazolol GABAA Competitive/Noncompetitive Antagonists: Synthesis and Pharmacology[J]. Journal of Medicinal Chemistry, 2006, 49 4: 1388-1396. DOI: 10.1021/jm050987l
[4] ICHIRO UCHIDA  Jay Y  Ismar N Cestari. The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons[J]. European journal of pharmacology, 1996, 307 1: Pages 89-96. DOI: 10.1016/0014-2999(96)00156-2
[5] SURESH K MENDU. Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes.[J]. PLoS ONE, 2012: e42959. DOI: 10.1371/journal.pone.0042959

SR-95531 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-95531 Suppliers

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104104-50-9, SR-95531Related Search:

SR 3677 dihydrochloride N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR 35021 SR-95531,SR 95531 HYDROBROMIDE,SR-95531 SPECIFIC GABA-A ANTAG,SR-95531,2-(3-Carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium SR-95531 SR95531, [BUTYRYL-2,3-3H]-

  • Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide
  • 1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide
  • 6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br
  • 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide
  • Gabazine Hydrobromide
  • 4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide
  • GABAZINE
  • GABAZINE BROMIDE
  • 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
  • 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE
  • 6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE
  • SR 95531 HYDROBROMIDE
  • SR-95531
  • SR 95531 hydrobromide NEW
  • SR 95531 hydrobromid
  • 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid
  • Gabazine bromide (SR95531)
  • Inhibitor,Gamma-aminobutyric acid Receptor,Gabazine,γ-Aminobutyric acid Receptor,inhibit,SR 95531,GABA Receptor,SR-95531
  • SR95531 (Gabazine) (mM/ml), GABAA antagonist
  • SR95531 (Gabazine), GABAA antagonist
  • Gabazine, 10 mM in DMSO
  • SR-95531【S106】
  • 104104-50-9
  • 104105-50-9
  • C15H17N3O3HBr
  • C15H18BrN3O3
  • C15H18N3O3Br
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Ion Channels
  • Ligand-Gated Ion Channels
  • GABA and Glycine Receptor Modulators
  • GABA/Glycine receptor