SR-95531

Product Name: SR-95531
CAS No.: 104104-50-9
Chemical Name: SR-95531
Synonyms: GABAZINE;SR-95531;GABAZINE BROMIDE;SR 95531 hydrobromid;Gabazine Hydrobromide;SR 95531 HYDROBROMIDE;SR 95531 hydrobromide NEW;Gabazine bromide (SR95531);4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
CBNumber: CB9356638
Molecular Formula: C15H18BrN3O3
Formula Weight: 368.23
MOL File: 104104-50-9.mol

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SR-95531 Property

Melting point:: 200 °C(Solv: ethanol (64-17-5))
storage temp.: Store at RT
solubility: DMSO: 30 mg/mL
form: solid
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S106
Product name: SR-95531
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $644
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.05986
Product name: SR95531 (Gabazine) - CAS 104104-50-9 - Calbiochem
Packaging: 10mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 14585
Product name: SR 95531 (hydrobromide)
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 14585
Product name: SR 95531 (hydrobromide)
Purity: ≥98%
Packaging: 10mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: S106
Product name: SR-95531
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $191
Updated: 2024/03/01

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SR-95531 Chemical Properties,Usage,Production

Description

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABA_A receptors (K_i = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABA_A receptor isoforms from mice, rats, and humans.

Uses

Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.

Biological Activity

Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

storage

Room temperature

SR-95531 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-95531 Suppliers

China 70 Europe 1 Germany 2 India 3 Switzerland 1 United Kingdom 4 United States 11 Global 92

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
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VDM Biochemicals

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Email: sales@vdmbio.com
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Fax: 021-50323701
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Country: China
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Shanghai Raise Chemical Technology Co.,Ltd

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Email: rs@raise-chem.com
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Sigma-Aldrich

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AN PharmaTech Co Ltd

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EMMX Biotechnology LLC

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Shanghai EFE Biological Technology Co., Ltd.

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Amadis Chemical Company Limited

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104104-50-9, SR-95531Related Search:

SR 3677 dihydrochloride N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR 35021 SR-95531,SR 95531 HYDROBROMIDE,SR-95531 SPECIFIC GABA-A ANTAG,SR-95531,2-(3-Carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium SR-95531 SR95531, [BUTYRYL-2,3-3H]-

Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide

1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide

6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br

6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide

Gabazine Hydrobromide

4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide

GABAZINE

GABAZINE BROMIDE

2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM

2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE

6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE

SR 95531 HYDROBROMIDE

SR-95531

SR 95531 hydrobromide NEW

SR 95531 hydrobromid

4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid

Gabazine bromide (SR95531)

Inhibitor,Gamma-aminobutyric acid Receptor,Gabazine,γ-Aminobutyric acid Receptor,inhibit,SR 95531,GABA Receptor,SR-95531

104104-50-9

104105-50-9

C15H17N3O3HBr

C15H18BrN3O3

C15H18N3O3Br

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Ion Channels

Ligand-Gated Ion Channels

GABA and Glycine Receptor Modulators

GABA/Glycine receptor