ChemicalBook > CAS DataBase List > Sucralose

Sucralose

Product Name
Sucralose
CAS No.
56038-13-2
Chemical Name
Sucralose
Synonyms
TGS;ctopyranoside;loro-4-deoxy-;Sucralose 0.1;TRICHLOROSUCROSE;Sucralose in stock GMP Factory;4,1’,6’-trichloro-4,1’,6’-trideoxy-galacto-sucrose;E955;ucralose;SUCRALOSE
CBNumber
CB9363034
Molecular Formula
C12H19Cl3O8
Formula Weight
397.63
MOL File
56038-13-2.mol
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Sucralose Property

Melting point:
115-1018°C
Boiling point:
104-107 C
alpha 
D +68.2° (c = 1.1 in ethanol)
Density 
1.375 g/cm
vapor pressure 
0Pa at 25℃
storage temp. 
2-8°C
form 
Powder
pka
12.52±0.70(Predicted)
color 
White
PH
6-8 (100g/l, H2O, 20°C)
Odor
wh. cryst. powd., odorless, sweet taste
optical activity
[α]/D 86.0±2.0°, c = 1 in H2O
Water Solubility 
Soluble in Water.
Merck 
14,8880
BRN 
3654410
Stability:
Hygroscopic
LogP
-0.51 at 20℃
CAS DataBase Reference
56038-13-2(CAS DataBase Reference)
EPA Substance Registry System
.alpha.-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl 4-chloro-4-deoxy- (56038-13-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25
WGK Germany 
3
RTECS 
LW5440140
HS Code 
2932 14 00
Hazardous Substances Data
56038-13-2(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 10000 mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1.00895
Product name
Sucralose granular
Purity
EMPROVE?ESSENTIALPhEur,NF,JPE
Packaging
10g
Price
$33
Updated
2024/03/01
Sigma-Aldrich
Product number
69293
Product name
Sucralose
Purity
≥98.0% (HPLC)
Packaging
100g
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
1.00895
Product name
Sucralose granular
Purity
EMPROVE?ESSENTIALPhEur,NF,JPE
Packaging
1kg
Price
$487
Updated
2024/03/01
Sigma-Aldrich
Product number
1623626
Product name
Sucralose
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
400mg
Price
$491
Updated
2024/03/01
Sigma-Aldrich
Product number
1.00895
Product name
Sucralose granular
Purity
EMPROVE?ESSENTIALPhEur,NF,JPE
Packaging
10Kg
Price
$6750
Updated
2024/03/01
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Sucralose Chemical Properties,Usage,Production

Description

Sucralose is the only non-caloric sweetener made from sugar. It is in fact the latest non nutritive sweetener to have been approved by US FDA and other regulatory bodies and have hit the markets .
Sucralose is derived from sugar through a multi-step patented manufacturing process that selectively substitutes three atoms of chlorine for three hydroxyl groups on the sugar molecule. This change produces a sweetener that has no calories, yet is 600 times sweeter than sucrose, making it roughly twice as sweet as saccharin and four times as sweet as aspartame.

Chemical Properties

Sucralose is a white to off-white colored, free-flowing, crystalline powder.

History

Sucralose, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl- 4-chloro-4-deoxy-α-D-galactopyranoside, is a trichloro-galactosucrose sweetener developed by the British sugar company Tate & Lyle during the 1970s (U.S. Pat. 4,343,934 (Aug. 10, 1982), M. R. Jenner and D. Waite (to Talres Development), (U.S. Pat. 4,362,869 (Dec. 7, 1982), M. R. Jenner and co-workers (to Talres Development), and (U.S. Pat. 4,435,440 (Mar. 6, 1984), L. Hough, S. P. Phadnis, and R. A. Khan (to Tate & Lyle). It was licensed to McNeil-PPC, Inc., a Johnson & Johnson subsidiary, in the United States until a new agreement took place in February, 2004. McNeil Nutritionals retained ownership of SPLENDA Brand and the right for its worldwide retail and food service business. Tate & Lyle became the sole manufacturer of SPLENDA Brand sucralose and owned the right for its worldwide ingredient sales.

Uses

antiprotozoal

Uses

Sucralose (1,6-dichloro-1,6-dideoxy-p-fructofuranosyl-4-chloro-oc- D-galactopyra- noside) is a nonnutritive sweetener based on sucrose. It is selectively chlorinated and the glycoside link between the two rings is resistant to hydrolysis by acid or enzymes, so it is not metabolized. It has 400 to 800 times the sweetness of sucrose, is very soluble in water, and is stable in heat. It can be used in food products that are baked or fried.
Sucralose is produced by the selective chlorination of the sucrose molecule using a patented process by Tate and LyIe that replaces the three hydroxyl groups (OH) with three chlorine (Cl) atoms.
This modified sugar is minimally absorbed by the body and passes out unchanged. It was approved for use in foods and beverages in 1999 in the United States.

Uses

A low-calorie artificial sweetener

Uses

High intensity sweetener manufactured by replacing three hydroxyl groups on the sucrose molecule with three chlorine atoms. The results are a sweetener of 0 cal that is not digested. It is 600 times as sweet as sugar with a similar flavor profile. It is heat stable, readily soluble, and maintains its stability at elevated temperatures. It has been approved for use in specific categories that include baked products, beverages, confectioneries, and certain desserts and toppings.

Definition

ChEBI: A disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond.

Production Methods

Sucralose may be prepared by a variety of methods that involve the selective substitution of three sucrose hydroxyl groups by chlorine. Sucralose can also be synthesized by the reaction of sucrose (or an acetate) with thionyl chloride.

General Description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Sucralose is a polar, chlorinated sugar synthesized from saccharose precursor. It is widely used as a sweetener in a number of food and beverage products.

Pharmaceutical Applications

Sucralose is used as a sweetening agent in beverages, foods, and pharmaceutical applications. It has a sweetening power approximately 300–1000 times that of sucrose and has no aftertaste. It has no nutritional value, is noncariogenic, does not promote dental caries, and produces no glycemic response.

Biochem/physiol Actions

A synthetic sweet tastant detectable by humans. Activates T1R2/T1R3 sweet taste receptors on enteroendocrine cells and elicits increased hormonal secretion of glucagon-like peptide-1 and glucose-dependent insulinotrophic peptide.

Safety

Sucralose is generally regarded as a nontoxic and nonirritant material and is approved, in a number of countries, for use in food products. Following oral consumption, sucralose is mainly unabsorbed and is excreted in the feces.
The WHO has set an acceptable daily intake for sucralose of up to 15 mg/kg body-weight.
LD50 (mouse, oral): > 16 g/kg
LD50 (rat, oral): > 10 g/kg

storage

Sucralose is a relatively stable material. In aqueous solution, at highly acidic conditions (pH < 3), and at high temperatures (≤35℃), it is hydrolyzed to a limited extent, producing 4-chloro-4- deoxygalactose and 1,6-dichloro-1,6-dideoxyfructose. In food products, sucralose remains stable throughout extended storage periods, even at low pH. However, it is most stable at pH 5–6.
Sucralose should be stored in a well-closed container in a cool, dry place, at a temperature not exceeding 21℃. Sucralose, when heated at elevated temperatures, may break down with the release of carbon dioxide, carbon monoxide, and minor amounts of hydrogen chloride.

Regulatory Status

The FDA, in April 1998, approved sucralose for use as a tabletop sweetener and as an additive in a variety of food products. In the UK, sucralose was fully authorized for use in food products in 2005. It is also accepted for use in many other countries worldwide. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Sucralose Preparation Products And Raw materials

Raw materials

Sweetening agent Sucrose Raffinose β-Galactosidase Phosphorus pentachloride Triphenylantimony Monoester Thionyl chloride D-GALACTOSE 1-[2-(2-AZIDOETHOXY)ETHOXYETHYL]-2,3,4,6-TETRA-O-ACETATE

Preparation Products

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Sucralose Suppliers

Australia 1 Austria 2 Brazil 2 Canada 8 Chile 1 China 605 China Hong Kong 2 Czech Republic 1 Denmark 1 Egypt 1 Europe 2 France 1 Germany 14 India 67 Indonesia 4 Italy 6 Japan 3 Malaysia 1 Philippines 1 Poland 1 Singapore 2 South Africa 1 South Korea 1 Spain 6 Switzerland 3 Thailand 2 The Netherlands 2 Turkey 1 Ukraine 1 United Arab Emirates 1 United Kingdom 14 United States 81 Global 839
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View Lastest Price from Sucralose manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Sucralose 56038-13-2
Price
US $1000.00-400.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-12
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sucralose 56038-13-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-05-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Sucralose 56038-13-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-102%
Supply Ability
2000kg
Release date
2021-07-29

56038-13-2, SucraloseRelated Search:

Neotame Aspartame Sodium benzoate Sweetening agent Glycyrrhizic acid Alitame Acesulfame Saccharin D-tagatose Stevioside Thaumatin Molasses Trichlormethiazide 1',6,6'-Trichloro Sucrose Sucralose 6-Acetate 2,3,3',4,4'-penta-O-acetylsucrose Sucralose EP Impurity D 2,3,6,3',4'-penta-O-acetylsucrose

  • 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl4-chloro-4-deoxy-alpha-d-gala
  • 4,1’,6’-trichloro-4,1’,6’-trideoxy-galacto-sucrose
  • alpha-d-galactopyranoside,1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl4-ch
  • ctopyranoside
  • Sucralose in stock GMP Factory
  • 1,6-dichloro-1
  • 4,1',6'-trichlorogalactosucrose
  • loro-4-deoxy-
  • 1,6-DICHLORO-1,6-DIDEOXY-BETA-D-FRUCTOFURANOSYL-4-CHLORO-4-DEOXY-ALPHA-D-GALACOTOPYRANOSIDE
  • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactose
  • SUCRALOSE
  • TRICHLOROSUCROSE
  • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside
  • SUCRALOSE FCC (TRICHLOROGALACTOSUCROSE)
  • SucraloseC12H19Cl3O8
  • Sucralose98%Min.
  • Sucralose99%
  • Steviosides90%
  • Sucralose&Int.
  • SPLENDA [R]
  • .alpha.-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl 4-chloro-4-deoxy-
  • trichlorogalactosucrose
  • 4,16trichloro-4,16trideoxy pentagalactosucrose
  • SUCRALOSE /4,1'',6'',-TRICHLORO-4,1'',6''TRIDEOXY-PENTAGALACTOSUCROSE
  • SUCRALOSE(TRICHLOROSUCROSE)
  • Sucralose 98.0-102.0%
  • 4,1,6-TRICHLOROGALACTOSUCROSE (SUCRALOSE)
  • 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galacotopyranoside
  • 1,6-Dichloro-1,6-Dideoxy-B-D-Fructofuranosyl-4-Chloro-4-Deoxy-A-D-Galacotopyranoside
  • (2R,3R,4R,5R,6R)-2-{[(2S,3R,4R,5R)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydro furan-2-yl]oxy}-
  • Sucralose 0.1
  • α-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-
  • E955,Trichlorosucrose
  • (2R,3R,4R,5R,6R)-2-{[(2S,3R,4R,5R)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydrofuran-2-yl]oxy}-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol (Sucralose)
  • TGS
  • E955, Trichlorosucrose, 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside
  • 4，1’，6’-trichloro-galactosucorose
  • trichlorosucorose
  • 1',4,6'-Trichloro-galacto-sucrose
  • 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactopyranoside
  • (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-oxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
  • (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
  • (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl]oxy-5-chloro-6-methylol-tetrahydropyran-3,4-diol
  • (2R,3R,4R,5R,6R)-2-((2R,3S,4S,5S)-2,5-Bis(Chloromethyl)-3,4-Dihydroxytetrahydrofuran-2-Yloxy)-5-Chloro-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4-Diol
  • SUBERIC ACID(RG)
  • E955
  • Sucralose,1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside, E955, Trichlorosucrose
  • Sucralose (400 mg)
  • Sucralose (400 mg)G1E3170.998mg/mg(ai)
  • Sucralose, FCC
  • Sucralose, NF
  • 2-{[2,5-bis(chloroMethyl)-3,4-dihydroxyoxolan-2-yl]oxy}-5-chloro-6-(hydroxyMethyl)oxane-3,4-diol
  • 1-(1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl)-4-chloro-4-deoxy-alpha-D-galactopyranoside
  • SUCRALOSE(P)
  • Sucralose ,98%
  • Sucralose (E955
  • Sucralose &gt
  • Sucralose Standard