alpha-Bromo-p-toluenesulphonyl chloride
- Product Name
- alpha-Bromo-p-toluenesulphonyl chloride
- CAS No.
- 66176-39-4
- Chemical Name
- alpha-Bromo-p-toluenesulphonyl chloride
- Synonyms
- BUTTPARK 94\04-08;4-Bromomethylbenzenesulfonyl c;4-(Chlorosulphonyl)benzyl bromide;α-bromo-p-toluenesulfonyl chloride;à-bromo-p-toluenesulfonyl chloride;alpha-Bromo-p-toluenesulfonylchloride;ALPHA-BROMO-P-TOLUENESULPHONYL CHLORIDE;4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE;4-bromo methy benzene sulfonyl chloride;4-(BROMOMETHYL)BENZENESULPHONYL CHLORIDE
- CBNumber
- CB9364844
- Molecular Formula
- C7H6BrClO2S
- Formula Weight
- 269.54
- MOL File
- 66176-39-4.mol
alpha-Bromo-p-toluenesulphonyl chloride Property
- Melting point:
- 71-75 °C(lit.)
- Boiling point:
- 160-170 °C
- Density
- 1.6944 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- color
- Off-white to light yellow
- Sensitive
- Moisture Sensitive
- BRN
- 2364328
- CAS DataBase Reference
- 66176-39-4(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 557153
- Product name
- 4-(Bromomethyl)benzenesulfonyl chloride
- Purity
- 95%
- Packaging
- 5g
- Price
- $110
- Updated
- 2025/07/31
- Product number
- 557153
- Product name
- 4-(Bromomethyl)benzenesulfonyl chloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $34.8
- Updated
- 2023/06/20
- Product number
- B3936
- Product name
- 4-(Bromomethyl)benzenesulfonyl Chloride
- Purity
- >95.0%(GC)(T)
- Packaging
- 1g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- B3936
- Product name
- 4-(Bromomethyl)benzenesulfonyl Chloride
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- B688250
- Product name
- α-Bromo-p-toluenesulfonylChloride
- Packaging
- 100g
- Price
- $1265
- Updated
- 2021/12/16
alpha-Bromo-p-toluenesulphonyl chloride Chemical Properties,Usage,Production
Chemical Properties
off-white to light yellow crystalline powder
Uses
4-(Bromomethyl)benzenesulfonyl chloride may be used to synthesize:
- 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide
- benzene-sulfonamide derivatives, which are potent Chemokine Receptor Type 4 (CXCR4) inhibitors
- imidazole derivatives having antifungal activity
Synthesis
98-59-9
66176-39-4
General procedure for the synthesis of 4-bromomethylbenzenesulfonyl chloride from p-toluenesulfonyl chloride: to a stirred solution of p-toluenesulfonyl chloride (20 g, 104.9 mmol) in carbon tetrachloride (500 mL) was added sequentially N-bromosuccinimide (20.6 g, 115.7 mmol) and benzoyl peroxide (2.54 g, 10.84 mmol) at room temperature. The reaction mixture was refluxed for 10 hours and then filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give a yellow oil. The oily substance was recrystallized using hexane as eluent to give 4-bromomethylbenzenesulfonyl chloride (20.6 g, 65% yield) as a final white solid.
References
[1] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 5, p. 1487 - 1493
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4197 - 4204
[3] Journal of the American Chemical Society, 1957, vol. 79, p. 4232
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2437 - 2451
[5] Patent: US5318980, 1994, A
alpha-Bromo-p-toluenesulphonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
alpha-Bromo-p-toluenesulphonyl chloride Suppliers
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- Country
- Germany
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View Lastest Price from alpha-Bromo-p-toluenesulphonyl chloride manufacturers
- Product
- alpha-Bromo-p-toluenesulphonyl chloride 66176-39-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- alpha-Bromo-p-toluenesulphonyl chloride 66176-39-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 100kg/week
- Release date
- 2019-08-05