ChemicalBook > CAS DataBase List > alpha-Bromo-p-toluenesulphonyl chloride

alpha-Bromo-p-toluenesulphonyl chloride

Product Name
alpha-Bromo-p-toluenesulphonyl chloride
CAS No.
66176-39-4
Chemical Name
alpha-Bromo-p-toluenesulphonyl chloride
Synonyms
BUTTPARK 94\04-08;4-Bromomethylbenzenesulfonyl c;4-(Chlorosulphonyl)benzyl bromide;α-bromo-p-toluenesulfonyl chloride;à-bromo-p-toluenesulfonyl chloride;alpha-Bromo-p-toluenesulfonylchloride;ALPHA-BROMO-P-TOLUENESULPHONYL CHLORIDE;4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE;4-bromo methy benzene sulfonyl chloride;4-(BROMOMETHYL)BENZENESULPHONYL CHLORIDE
CBNumber
CB9364844
Molecular Formula
C7H6BrClO2S
Formula Weight
269.54
MOL File
66176-39-4.mol
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alpha-Bromo-p-toluenesulphonyl chloride Property

Melting point:
71-75 °C(lit.)
Boiling point:
160-170 °C
Density 
1.6944 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Crystalline Powder
color 
Off-white to light yellow
Sensitive 
Moisture Sensitive
BRN 
2364328
CAS DataBase Reference
66176-39-4(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557153
Product name
4-(Bromomethyl)benzenesulfonyl chloride
Purity
95%
Packaging
5g
Price
$110
Updated
2025/07/31
Sigma-Aldrich
Product number
557153
Product name
4-(Bromomethyl)benzenesulfonyl chloride
Purity
95%
Packaging
1g
Price
$34.8
Updated
2023/06/20
TCI Chemical
Product number
B3936
Product name
4-(Bromomethyl)benzenesulfonyl Chloride
Purity
>95.0%(GC)(T)
Packaging
1g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
B3936
Product name
4-(Bromomethyl)benzenesulfonyl Chloride
Purity
>95.0%(GC)(T)
Packaging
5g
Price
$153
Updated
2025/07/31
TRC
Product number
B688250
Product name
α-Bromo-p-toluenesulfonylChloride
Packaging
100g
Price
$1265
Updated
2021/12/16
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alpha-Bromo-p-toluenesulphonyl chloride Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow crystalline powder

Uses

4-(Bromomethyl)benzenesulfonyl chloride may be used to synthesize:

  • 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide
  • benzene-sulfonamide derivatives, which are potent Chemokine Receptor Type 4 (CXCR4) inhibitors
  • imidazole derivatives having antifungal activity

Synthesis

98-59-9

66176-39-4

General procedure for the synthesis of 4-bromomethylbenzenesulfonyl chloride from p-toluenesulfonyl chloride: to a stirred solution of p-toluenesulfonyl chloride (20 g, 104.9 mmol) in carbon tetrachloride (500 mL) was added sequentially N-bromosuccinimide (20.6 g, 115.7 mmol) and benzoyl peroxide (2.54 g, 10.84 mmol) at room temperature. The reaction mixture was refluxed for 10 hours and then filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give a yellow oil. The oily substance was recrystallized using hexane as eluent to give 4-bromomethylbenzenesulfonyl chloride (20.6 g, 65% yield) as a final white solid.

References

[1] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 5, p. 1487 - 1493
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4197 - 4204
[3] Journal of the American Chemical Society, 1957, vol. 79, p. 4232
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2437 - 2451
[5] Patent: US5318980, 1994, A

alpha-Bromo-p-toluenesulphonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from alpha-Bromo-p-toluenesulphonyl chloride manufacturers

Henan Fengda Chemical Co., Ltd
Product
alpha-Bromo-p-toluenesulphonyl chloride 66176-39-4
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Career Henan Chemical Co
Product
alpha-Bromo-p-toluenesulphonyl chloride 66176-39-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
100kg/week
Release date
2019-08-05

66176-39-4, alpha-Bromo-p-toluenesulphonyl chlorideRelated Search:

Benzenesulfonyl chloride Mesitylene-2-sulfonyl chloride alpha-Bromo-p-toluenesulphonyl chloride alpha-Toluenesulfonyl chloride

  • BUTTPARK 94\04-08
  • ALPHA-BROMO-P-TOLUENESULPHONYL CHLORIDE
  • 4-(BROMOMETHYL)BENZENE-1-SULFONYL CHLORIDE
  • 4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE
  • 4-(BROMOMETHYL)BENZENESULPHONYL CHLORIDE
  • 4-(BROMOMETHYLENE)BENZENESULFONYL CHLORIDE
  • à-bromo-p-toluenesulfonyl chloride
  • α-bromo-p-toluenesulfonyl chloride
  • 4-(Bromomethyl)benzenesulphonyl chloride 98%
  • alpha-Bromo-p-toluenesulfonylchloride
  • 4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE 95%
  • 4-Bromomethylbenzenesulfonyl chloride,95%
  • 4-(Chlorosulphonyl)benzyl bromide
  • 4-(Bromomethyl)benzenesulfonyl Chloride &gt
  • Benzenesulfonyl chloride, 4-(bromomethyl)-
  • alpha-Bromo-p-toluenesulphonyl chloride ISO 9001：2015 REACH
  • 4-bromo methy benzene sulfonyl chloride
  • 4-Bromomethylbenzenesulfonyl c
  • 66176-39-4
  • BrCH2C6H4SO2Cl
  • C7H6O2BrClS
  • C7H6BrCIO2S
  • SULFONYL CHLORIDE
  • Building Blocks
  • Organic Building Blocks
  • Sulfonyl Halides
  • Sulfur Compounds
  • Benzenesulfonyl chloride