ChemicalBook > CAS DataBase List > 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE

5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE

Product Name: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE
CAS No.: 147619-40-7
Chemical Name: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE
Synonyms: GimeracilImpurity19;3-Cyano GiMeracil Methyl Ether;5-Chloro-3-cyano-4-methoxy-2(1H)-pyridone;5-Chloro-3-Cyano-4-methony-2-(1H)-pyridinone;5-chloro-1,2-dihydro-4-methoxy-2-oxopyridine-3-carbonitrile;3-pyridinecarbonitrile, 5-chloro-1,2-dihydro-4-methoxy-2-ox;5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE;5-Chloro-4-Methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile;3-pyridinecarbonitrile, 5-chloro-1,2-dihydro-4-methoxy-2-oxo-;MPC 5-chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
CBNumber: CB9373532
Molecular Formula: C7H5ClN2O2
Formula Weight: 184.58
MOL File: 147619-40-7.mol

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5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Property

Boiling point:: 376.8±42.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Dimethyl Sulfoxide, Methanol
form: Solid
pka: 5.93±0.10(Predicted)
color: Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C981310
Product name: 3-CyanoGimeracilMethylEther
Packaging: 10g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148588
Product name: 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
Packaging: 25mg
Price: $63
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148588
Product name: 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
Packaging: 50mg
Price: $109
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148588
Product name: 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
Packaging: 100mg
Price: $190
Updated: 2021/12/16

AK Scientific

Product number: 7343AA
Product name: 5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile
Packaging: 5g
Price: $230
Updated: 2021/12/16

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5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

3-Cyano Gimeracil Methyl Ether is a useful Intermediate in the synthesis of the antitumor agent Gimeracil.

Uses

Intermediate in the synthesis of antitumor agent Gimeracil.

Synthesis

21642-98-8

147619-40-7

General procedure for the synthesis of 5-chloro-2-hydroxy-3-cyano-4-methoxypyridine from 4-methoxy-2-oxo-1,2-dihydro-3-cyano-pyridine: 3-cyano-4-methoxy-2(1H)-pyridinone (6.0 g, 0.04 mol) was added to a 250 mL three-necked flask along with 45 mL of glacial acetic acid, and cooled down to below 15 °C. Subsequently, sulfonyl chloride (6.18 g, 0.045 mol) was added slowly, and the temperature of the reaction solution was controlled between 10 and 15 °C, and the titration rate was adjusted according to the temperature change. After the dropwise addition, stirring was continued for 30 min. Then, the reaction mixture was heated to 52 ± 2 °C and the reaction was held at 50-54 °C for 4 hours. The reaction process was monitored by thin layer chromatography (TLC, unfolding agent: ethyl acetate/methanol = 9:1). After confirming the complete reaction of the ingredients, the reaction solution was cooled to 20±2°C and stirred for 2 hours. The solid product was collected by filtration and the filter cake was washed with 58 mL of water. The wet product was dried at 80 °C under atmospheric pressure for 12 h to give 7.01 g of 3-cyano-4-methoxy-5-chloro-2(1H)-pyridinone as a white powder in 95.0% yield (theoretical yield 7.38 g).

References

[1] Patent: CN106316934, 2017, A. Location in patent: Paragraph 0022; 0023; 0025; 0027; 0028
[2] Patent: CN103664772, 2016, B. Location in patent: Paragraph 0013-0017
[3] Heterocycles, 1993, vol. 36, # 1, p. 145 - 148

5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 147619-40-7
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-09-08

Shaanxi Dideu Medichem Co. Ltd

Product: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE 147619-40-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE 147619-40-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

147619-40-7, 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILERelated Search:

5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Gimeracil 3-Cyano-1,2-dihydro-4-hydroxy-2-oxopyridine 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE

5-Chloro-3-cyano-4-methoxy-2(1H)-pyridone

3-Cyano GiMeracil Methyl Ether

5-Chloro-4-Methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile

3-pyridinecarbonitrile, 5-chloro-1,2-dihydro-4-methoxy-2-oxo-

MPC 5-chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile

3-pyridinecarbonitrile, 5-chloro-1,2-dihydro-4-methoxy-2-ox

5-Chloro-3-Cyano-4-methony-2-(1H)-pyridinone

5-chloro-1,2-dihydro-4-methoxy-2-oxopyridine-3-carbonitrile

5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE ISO 9001：2015 REACH

GimeracilImpurity19

147619-40-7

C7H5ClN2O2

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