5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE
- Product Name
- 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE
- CAS No.
- 147619-40-7
- Chemical Name
- 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE
- Synonyms
- GimeracilImpurity19;3-Cyano GiMeracil Methyl Ether;5-Chloro-3-cyano-4-methoxy-2(1H)-pyridone;5-Chloro-3-Cyano-4-methony-2-(1H)-pyridinone;5-chloro-1,2-dihydro-4-methoxy-2-oxopyridine-3-carbonitrile;3-pyridinecarbonitrile, 5-chloro-1,2-dihydro-4-methoxy-2-ox;5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE;5-Chloro-4-Methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile;3-pyridinecarbonitrile, 5-chloro-1,2-dihydro-4-methoxy-2-oxo-;MPC 5-chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
- CBNumber
- CB9373532
- Molecular Formula
- C7H5ClN2O2
- Formula Weight
- 184.58
- MOL File
- 147619-40-7.mol
5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Property
- Boiling point:
- 376.8±42.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Dimethyl Sulfoxide, Methanol
- form
- Solid
- pka
- 5.93±0.10(Predicted)
- color
- Light Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C981310
- Product name
- 3-CyanoGimeracilMethylEther
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC148588
- Product name
- 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
- Packaging
- 25mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- FC148588
- Product name
- 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
- Packaging
- 50mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- FC148588
- Product name
- 5-Chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
- Packaging
- 100mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 7343AA
- Product name
- 5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile
- Packaging
- 5g
- Price
- $230
- Updated
- 2021/12/16
5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Solid
Uses
3-Cyano Gimeracil Methyl Ether is a useful Intermediate in the synthesis of the antitumor agent Gimeracil.
Uses
Intermediate in the synthesis of antitumor agent Gimeracil.
Synthesis
21642-98-8
147619-40-7
General procedure for the synthesis of 5-chloro-2-hydroxy-3-cyano-4-methoxypyridine from 4-methoxy-2-oxo-1,2-dihydro-3-cyano-pyridine: 3-cyano-4-methoxy-2(1H)-pyridinone (6.0 g, 0.04 mol) was added to a 250 mL three-necked flask along with 45 mL of glacial acetic acid, and cooled down to below 15 °C. Subsequently, sulfonyl chloride (6.18 g, 0.045 mol) was added slowly, and the temperature of the reaction solution was controlled between 10 and 15 °C, and the titration rate was adjusted according to the temperature change. After the dropwise addition, stirring was continued for 30 min. Then, the reaction mixture was heated to 52 ± 2 °C and the reaction was held at 50-54 °C for 4 hours. The reaction process was monitored by thin layer chromatography (TLC, unfolding agent: ethyl acetate/methanol = 9:1). After confirming the complete reaction of the ingredients, the reaction solution was cooled to 20±2°C and stirred for 2 hours. The solid product was collected by filtration and the filter cake was washed with 58 mL of water. The wet product was dried at 80 °C under atmospheric pressure for 12 h to give 7.01 g of 3-cyano-4-methoxy-5-chloro-2(1H)-pyridinone as a white powder in 95.0% yield (theoretical yield 7.38 g).
References
[1] Patent: CN106316934, 2017, A. Location in patent: Paragraph 0022; 0023; 0025; 0027; 0028
[2] Patent: CN103664772, 2016, B. Location in patent: Paragraph 0013-0017
[3] Heterocycles, 1993, vol. 36, # 1, p. 145 - 148
5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE Suppliers
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- Country
- India
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View Lastest Price from 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE manufacturers
- Product
- 5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 147619-40-7
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE 147619-40-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE 147619-40-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21