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Gimeracil

Product Name
Gimeracil
CAS No.
103766-25-2
Chemical Name
Gimeracil
Synonyms
CDHP;CDH3;CS-84;Gimost;gimestat;imeraciL;GIMERACIL;Gimeradll;Cadherin-3;P-cadherin
CBNumber
CB5362004
Molecular Formula
C5H4ClNO2
Formula Weight
145.54
MOL File
103766-25-2.mol
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Gimeracil Property

Melting point:
274 °C
Boiling point:
255.1±40.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 5 mg/ml).
pka
4.50±1.00(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
ZPLQIPFOCGIIHV-UHFFFAOYSA-N
CAS DataBase Reference
103766-25-2(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2075
Product name
Gimeracil
Purity
≥98% (HPLC)
Packaging
5MG
Price
$64.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2075
Product name
Gimeracil
Purity
≥98% (HPLC)
Packaging
25MG
Price
$159
Updated
2024/03/01
TCI Chemical
Product number
C2243
Product name
Gimeracil
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
C2243
Product name
Gimeracil
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$295
Updated
2024/03/01
Cayman Chemical
Product number
16525
Product name
Gimeracil
Purity
≥98%
Packaging
100mg
Price
$68
Updated
2024/03/01
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Gimeracil Chemical Properties,Usage,Production

Description

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

Chemical Properties

Off-White Solid

Uses

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Uses

Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

Uses

Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)

Definition

ChEBI: Gimeracil is an organic molecular entity.

References

1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712

Gimeracil Preparation Products And Raw materials

Raw materials

Preparation Products

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Gimeracil Suppliers

Jinan Sunshine Pharmaceutical Co.,Ltd.
Tel
531-82812892
Fax
0531-82812892
Email
sunshinepharm0531@163.com
Country
China
ProdList
68
Advantage
58
Shandong Zhongke Taidou Chemical Co., Ltd.
Tel
0531-88682302 18615650139
Fax
0531-62325738
Email
3303447386@qq.com
Country
China
ProdList
112
Advantage
62
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
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View Lastest Price from Gimeracil manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Gimeracil 103766-25-2
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-09
Hebei Weibang Biotechnology Co., Ltd
Product
Cocal 103766-25-2
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-07-14
Henan Bao Enluo International TradeCo.,LTD
Product
Gimeracil 103766-25-2
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-02

103766-25-2, GimeracilRelated Search:


  • GIMERACIL
  • gimestat
  • 5-Chloro-2,4-dihydroxypyridine
  • 5-Chloro-4-hydroxy-2(1H)-pyridinone
  • 5-Chloro-4-hydroxy-2-pyridone
  • 2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI)
  • 5-chloropyridine-2,4-diol
  • 2(1H)-Pyridinone, 5-chloro-4-hydroxy-
  • Gimeracil,(CDHP)
  • CDHP
  • 5-Chloro-2,4-pyridinediol
  • 5-Chloro-4-hydroxy-2(1H)-pyridone
  • CS-84
  • (CDHP)Gimeracil
  • 5-Chloro-4-hydroxy-2(1H)-pyridinone,5-chloro-2,4-pyridinediol,cdhp compound
  • 5-Chloro-4-hydroxy pyridine-2(1H)-one (GIMERACIL)
  • 5-Chloro-2,4-dihydroxypyridine 5-Chloro-2,4-pyridinediol 5-Chloro-4-hydroxy-2(1H)-pyridinone
  • Gimeracil Gimestat
  • Anti-CDH3, N-Terminal antibody produced in rabbit
  • Cadherin-3
  • CDH3
  • P-cadherin
  • Placental cadherin
  • Gimeracil Imp.(4-ME-CDHP)
  • Gimeracil, >=99%
  • Gimeracil &gt
  • imeraciL
  • 5-chloro-4-hydroxy-1,2-dihydropyridin-2-one
  • Recombinant Human Cadherin-3/CDH3 Protein, His Tag
  • Recombinant Mouse P-Cadherin/Cdh3 Protein, Fc Tag
  • Gimeracil ISO 9001:2015 REACH
  • Gimost
  • Gimeradll
  • 103766-25-2
  • Antitumors for Research and Experimental Use
  • PYRIDINE
  • Anticancer
  • oncology
  • Biochemistry
  • Chloropyridines
  • Halopyridines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 103766-25-2