ChemicalBook > CAS DataBase List > Gimeracil

Gimeracil

Product Name
Gimeracil
CAS No.
103766-25-2
Chemical Name
Gimeracil
Synonyms
CDHP;CDH3;CS-84;Gimost;gimestat;imeraciL;GIMERACIL;Gimeradll;Cadherin-3;P-cadherin
CBNumber
CB5362004
Molecular Formula
C5H4ClNO2
Formula Weight
145.54
MOL File
103766-25-2.mol
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Gimeracil Property

Melting point:
274 °C
Boiling point:
255.1±40.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 5 mg/ml).
pka
4.50±1.00(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
ZPLQIPFOCGIIHV-UHFFFAOYSA-N
CAS DataBase Reference
103766-25-2(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2075
Product name
Gimeracil
Purity
≥98% (HPLC)
Packaging
5MG
Price
$64.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2075
Product name
Gimeracil
Purity
≥98% (HPLC)
Packaging
25MG
Price
$159
Updated
2024/03/01
TCI Chemical
Product number
C2243
Product name
Gimeracil
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
C2243
Product name
Gimeracil
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$295
Updated
2024/03/01
Cayman Chemical
Product number
16525
Product name
Gimeracil
Purity
≥98%
Packaging
100mg
Price
$68
Updated
2024/03/01
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Gimeracil Chemical Properties,Usage,Production

Description

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

Chemical Properties

Off-White Solid

Uses

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Uses

Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

Uses

Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)

Definition

ChEBI: Gimeracil is an organic molecular entity.

References

1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712

Gimeracil Preparation Products And Raw materials

Raw materials

Preparation Products

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Gimeracil Suppliers

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Jinan Sunshine Pharmaceutical Co.,Ltd.
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View Lastest Price from Gimeracil manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Gimeracil 103766-25-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Henan Bao Enluo International TradeCo.，LTD
Product
Gimeracil 103766-25-2
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-02
Hebei Mojin Biotechnology Co., Ltd
Product
Gimeracil 103766-25-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2023-09-01

103766-25-2, GimeracilRelated Search:

2,4-Dihydroxypyridine 2-Chloro-5-chloromethylpyridine Clopidol 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE 5-Chloropyridine-2,3-diol 2,4-Dihydroxypyridine Gimeracil-13C3 Gimeracil AURORA KA-4855 AURORA KA-6096 AURORA KA-3471 AURORA KA-2491 AURORA KA-8145 AURORA KA-3473 AURORA KA-6035 AURORA KA-4741 AURORA KA-3807 AURORA KA-4737

  • GIMERACIL
  • gimestat
  • 5-Chloro-2,4-dihydroxypyridine
  • 5-Chloro-4-hydroxy-2(1H)-pyridinone
  • 5-Chloro-4-hydroxy-2-pyridone
  • 2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI)
  • 5-chloropyridine-2,4-diol
  • 2(1H)-Pyridinone, 5-chloro-4-hydroxy-
  • Gimeracil,(CDHP)
  • CDHP
  • 5-Chloro-2,4-pyridinediol
  • 5-Chloro-4-hydroxy-2(1H)-pyridone
  • CS-84
  • （CDHP）Gimeracil
  • 5-Chloro-4-hydroxy-2(1H)-pyridinone,5-chloro-2,4-pyridinediol,cdhp compound
  • 5-Chloro-4-hydroxy pyridine-2(1H)-one (GIMERACIL)
  • 5-Chloro-2,4-dihydroxypyridine 5-Chloro-2,4-pyridinediol 5-Chloro-4-hydroxy-2(1H)-pyridinone
  • Gimeracil Gimestat
  • Anti-CDH3, N-Terminal antibody produced in rabbit
  • Cadherin-3
  • CDH3
  • P-cadherin
  • Placental cadherin
  • Gimeracil Imp.(4-ME-CDHP)
  • Gimeracil, >=99%
  • Gimeracil &gt
  • imeraciL
  • 5-chloro-4-hydroxy-1,2-dihydropyridin-2-one
  • Recombinant Human Cadherin-3/CDH3 Protein, His Tag
  • Recombinant Mouse P-Cadherin/Cdh3 Protein, Fc Tag
  • Gimeracil ISO 9001：2015 REACH
  • Gimost
  • Gimeradll
  • 103766-25-2
  • Antitumors for Research and Experimental Use
  • PYRIDINE
  • Anticancer
  • oncology
  • Biochemistry
  • Chloropyridines
  • Halopyridines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 103766-25-2