Gimeracil
- Product Name
- Gimeracil
- CAS No.
- 103766-25-2
- Chemical Name
- Gimeracil
- Synonyms
- CDHP;CDH3;CS-84;Gimost;gimestat;imeraciL;GIMERACIL;Gimeradll;Cadherin-3;P-cadherin
- CBNumber
- CB5362004
- Molecular Formula
- C5H4ClNO2
- Formula Weight
- 145.54
- MOL File
- 103766-25-2.mol
Gimeracil Property
- Melting point:
- 274 °C
- Boiling point:
- 255.1±40.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to 5 mg/ml).
- pka
- 4.50±1.00(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey
- ZPLQIPFOCGIIHV-UHFFFAOYSA-N
- CAS DataBase Reference
- 103766-25-2(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML2075
- Product name
- Gimeracil
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $64.9
- Updated
- 2024/03/01
- Product number
- SML2075
- Product name
- Gimeracil
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $159
- Updated
- 2024/03/01
- Product number
- C2243
- Product name
- Gimeracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $89
- Updated
- 2024/03/01
- Product number
- C2243
- Product name
- Gimeracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $295
- Updated
- 2024/03/01
- Product number
- 16525
- Product name
- Gimeracil
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $68
- Updated
- 2024/03/01
Gimeracil Chemical Properties,Usage,Production
Description
Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3
Chemical Properties
Off-White Solid
Uses
Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.
Uses
Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
Uses
Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)
Definition
ChEBI: Gimeracil is an organic molecular entity.
References
1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712
Gimeracil Preparation Products And Raw materials
Raw materials
Preparation Products
Gimeracil Suppliers
- Tel
- --
- Fax
- --
- amakryaleas@aciceurope.eu
- Country
- Cyprus
- ProdList
- 52
- Advantage
- 58
View Lastest Price from Gimeracil manufacturers
- Product
- Gimeracil 103766-25-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- Gimeracil 103766-25-2
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-02
- Product
- Gimeracil 103766-25-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-09-01