Gimeracil

Product Name: Gimeracil
CAS No.: 103766-25-2
Chemical Name: Gimeracil
Synonyms: CDHP;CDH3;CS-84;Gimost;gimestat;imeraciL;GIMERACIL;Gimeradll;Cadherin-3;P-cadherin
CBNumber: CB5362004
Molecular Formula: C5H4ClNO2
Formula Weight: 145.54
MOL File: 103766-25-2.mol

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Gimeracil Property

Melting point:: 274 °C
Boiling point:: 255.1±40.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 5 mg/ml).
pka: 4.50±1.00(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: ZPLQIPFOCGIIHV-UHFFFAOYSA-N
CAS DataBase Reference: 103766-25-2(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2075
Product name: Gimeracil
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $64.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2075
Product name: Gimeracil
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $159
Updated: 2024/03/01

TCI Chemical

Product number: C2243
Product name: Gimeracil
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $89
Updated: 2024/03/01

TCI Chemical

Product number: C2243
Product name: Gimeracil
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $295
Updated: 2024/03/01

Cayman Chemical

Product number: 16525
Product name: Gimeracil
Purity: ≥98%
Packaging: 100mg
Price: $68
Updated: 2024/03/01

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Gimeracil Chemical Properties,Usage,Production

Description

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

Chemical Properties

Off-White Solid

Uses

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Uses

Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

Uses

Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)

Definition

ChEBI: Gimeracil is an organic molecular entity.

References

1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712

Gimeracil Preparation Products And Raw materials

Raw materials

Preparation Products

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Gimeracil Suppliers

Americas 1 Canada 3 China 281 Cyprus 1 Europe 4 Germany 1 India 9 Japan 2 South Korea 3 United Kingdom 7 United States 37 Global 349

Jinan Sunshine Pharmaceutical Co.,Ltd.

Tel: 531-82812892
Fax: 0531-82812892
Email: sunshinepharm0531@163.com
Country: China
ProdList: 68
Advantage: 58

Shandong Zhongke Taidou Chemical Co., Ltd.

Tel: 0531-88682302 18615650139
Fax: 0531-62325738
Email: 3303447386@qq.com
Country: China
ProdList: 112
Advantage: 62

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

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View Lastest Price from Gimeracil manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Gimeracil 103766-25-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Henan Bao Enluo International TradeCo.，LTD

Product: Gimeracil 103766-25-2
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-02

Hebei Mojin Biotechnology Co., Ltd

Product: Gimeracil 103766-25-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-01

103766-25-2, GimeracilRelated Search:

2,4-Dihydroxypyridine 2-Chloro-5-chloromethylpyridine Clopidol 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE 5-Chloropyridine-2,3-diol 2,4-Dihydroxypyridine Gimeracil-13C3 Gimeracil AURORA KA-4855 AURORA KA-6096 AURORA KA-3471 AURORA KA-2491 AURORA KA-8145 AURORA KA-3473 AURORA KA-6035 AURORA KA-4741 AURORA KA-3807 AURORA KA-4737

GIMERACIL

gimestat

5-Chloro-2,4-dihydroxypyridine

5-Chloro-4-hydroxy-2(1H)-pyridinone

5-Chloro-4-hydroxy-2-pyridone

2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI)

5-chloropyridine-2,4-diol

2(1H)-Pyridinone, 5-chloro-4-hydroxy-

Gimeracil,(CDHP)

CDHP

5-Chloro-2,4-pyridinediol

5-Chloro-4-hydroxy-2(1H)-pyridone

CS-84

（CDHP）Gimeracil

5-Chloro-4-hydroxy-2(1H)-pyridinone,5-chloro-2,4-pyridinediol,cdhp compound

5-Chloro-4-hydroxy pyridine-2(1H)-one (GIMERACIL)

5-Chloro-2,4-dihydroxypyridine 5-Chloro-2,4-pyridinediol 5-Chloro-4-hydroxy-2(1H)-pyridinone

Gimeracil Gimestat

Anti-CDH3, N-Terminal antibody produced in rabbit

Cadherin-3

CDH3

P-cadherin

Placental cadherin

Gimeracil Imp.(4-ME-CDHP)

Gimeracil, >=99%

Gimeracil &gt

imeraciL

5-chloro-4-hydroxy-1,2-dihydropyridin-2-one

Recombinant Human Cadherin-3/CDH3 Protein, His Tag

Recombinant Mouse P-Cadherin/Cdh3 Protein, Fc Tag

Gimeracil ISO 9001：2015 REACH

Gimost

Gimeradll

103766-25-2

Antitumors for Research and Experimental Use

PYRIDINE

Anticancer

oncology

Biochemistry

Chloropyridines

Halopyridines

Intermediates & Fine Chemicals

Pharmaceuticals

103766-25-2