2'-Deoxyadenosine monohydrate

ChemicalBook > CAS DataBase List > 2'-Deoxyadenosine monohydrate

2'-Deoxyadenosine monohydrate

Product Name: 2'-Deoxyadenosine monohydrate
CAS No.: 16373-93-6
Chemical Name: 2'-Deoxyadenosine monohydrate
Synonyms: 2-DEOXYADENOSINE MONOHYDRATE;2′-Da;Adenyldeoxy;2'-Deoxyadenosine mo;ADENINE DEOXYRIBOSIDE;2'-DEOXYADENOSINE:H2O;DEOXYADENOSINE HYDRATE;2'-Deoxy-adenosine ,98%;2-DEOXYADENOSINE H2O D2;2-deoxyadenosine 99-100%
CBNumber: CB9375521
Molecular Formula: C10H15N5O4
Formula Weight: 269.26
MOL File: 16373-93-6.mol

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2'-Deoxyadenosine monohydrate Property

Melting point:: 187-189 °C
refractive index: -25.5 ° (C=0.5, H2O)
storage temp.: 2-8°C
solubility: H2O: soluble50mg/mL, clear, colorless
form: powder
color: White to light beige
Water Solubility: 0.3 g/100 mL (20 ºC)
BRN: 5191174
Stability:: Stable, but air sensitive. Incompatible with strong oxidizing agents.
InChIKey: WZJWHIMNXWKNTO-VWZUFWLJSA-N
CAS DataBase Reference: 16373-93-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 24/25-37/39-36-26
RIDADR: UN2811 6.1/PG 3
WGK Germany: 3
RTECS: AU7358600
F: 10-23
TSCA: Yes
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D7400
Product name: 2′-Deoxyadenosine monohydrate
Purity: ≥99%
Packaging: 1g
Price: $73.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: D7400
Product name: 2′-Deoxyadenosine monohydrate
Purity: ≥99%
Packaging: 5g
Price: $225
Updated: 2024/03/01

TCI Chemical

Product number: D0046
Product name: 2'-Deoxyadenosine Monohydrate
Purity: >99.0%(T)
Packaging: 5g
Price: $58
Updated: 2024/03/01

TCI Chemical

Product number: D0046
Product name: 2'-Deoxyadenosine Monohydrate
Purity: >99.0%(T)
Packaging: 25g
Price: $229
Updated: 2024/03/01

Alfa Aesar

Product number: A11166
Product name: 2'-Deoxyadenosine monohydrate, 99%
Packaging: 1g
Price: $39
Updated: 2024/03/01

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2'-Deoxyadenosine monohydrate Chemical Properties,Usage,Production

Description

2'-Deoxyadenosine monohydrate is an adenosine nucleotide, which can be synthesized by the enzyme adenosine kinase. 2'-Deoxyadenosine monohydrate is a competitive inhibitor of phosphodiesterase, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis.

Chemical Properties

White crystalline powder

Uses

2'-Deoxyadenosineise is used by some cells as an energy source under energy stress conditions and to affect cAMP levels. 2'-dAdo is used in comparison studies of the functions of adenosine analogues on various biological processes.

Uses

2′-Deoxyadenosine monohydrate has been used:

as a component for nucleoside supplementation
as a standard for to estimate DNA global methylation rate in proliferating oil palm embryogenic suspensions
to reverse sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein (SAMHD1)
inhibition of human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV)

Uses

2'-Deoxyadenosine monohydrate is used in the synthesis of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.

Biochem/physiol Actions

Excess 2′-deoxyadenosine gets converted to adenosine triphosphate (dATP), which inhibits ribonucleotide reductase.

Purification Methods

Purify it by recrystallisation from H2O (hydrated crystals; solubility of the monohydrate is 1.1% in H2O at 20o). It has max 258nm (pH 1), 260nm (pH 7) and 261nm (pH 13). [Ness & Fletcher J Am Chem Soc 81 4752 1959, Walker & Butler Can J Chem 34 1168 1956.] The 3',5'-O-diacetyl derivative has m 151-152o (from EtOAc/pet ether). [Beilstein 26 III/IV 3589.]

2'-Deoxyadenosine monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2'-Deoxyadenosine monohydrate manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: 2'-Deoxyadenosine monohydrate 16373-93-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.7%
Supply Ability: 200000kg
Release date: 2024-04-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2'-Deoxyadenosine monohydrate 16373-93-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1000kg
Release date: 2023-01-13

Henan Bao Enluo International TradeCo.，LTD

Product: 2'-Deoxyadenosine monohydrate 16373-93-6
Price: US $80.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-11

16373-93-6, 2'-Deoxyadenosine monohydrateRelated Search:

ADENOSINE 5'-TRIPHOSPHATASE ERBIUM (III) 2,4-PENTANEDIONATE MELIBIOSE 2'-Deoxyadenosine 2'-Deoxyadenosine 5'-phosphate Cyclic AMP 8-BROMOADENOSINE 3'-ADENYLIC ACID 2-Chloroadenosine Vidarabine Adenosine 5'-monophosphate monohydrate N6-Benzoyl-2'-deoxyadenosine Bucladesine sodium N6-ISOPENTENYLADENOSINE-D6 N6-BENZYLADENOSINE ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 5'-Tosyladenosine N6,N6-DIMETHYLADENOSINE

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2''-DEOXYADENOSINE CELL CULTURE REAGENT WHITE CRYSTALLINE POWDER 98-100%

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2′-Da

9-(2-Deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6-aMine Hydrate

9-(2-Deoxy-β-D-erythro-pentofuranosyl)adenine

Adenine Deoxyribonucleoside Hydrate

Adenine Deoxyribose Hydrate

Adenyldeoxy

(2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-(hydroxyMethyl)tetrahydrofuran-3-ol hydrate

[8-2H]2'-deoxyadenosine Monohydrate

Adenosine, 2'-deoxy-,hydrate (1:1)

Deoxyadenosine Monohydrat

2'-Deoxyadenosine 1-hydrate

2'-Deoxyadenosine Monohydrate&gt

2'-Deoxyadenosine monohydrate USP/EP/BP

2-DEOXYADENOSINE H2O D2

2''-Deoxy-β-D-adenosine Monohydrate

2'-Deoxyadenosine Monohydrate, ≥ 99.0%

2'-Deoxyadenosine monohydrate(2'-dA.H2O)

2'-Deoxyadenosine monohydrate

16373-93-6

47810-77-9

C10H13N5O3xH2O

C10H13N5O3H2O

AMINE

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Nucleosides

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