2-(Chloromethyl)pyrimidine

Product Name: 2-(Chloromethyl)pyrimidine
CAS No.: 54198-88-8
Chemical Name: 2-(Chloromethyl)pyrimidine
Synonyms: EOS-62429;2-Chlormethyl-pyrimidin;2-chloroMrthyl pyriMidine;2-(CHLOROMETHYL)-PYRIMIDINE;2-(Chloromethyl)pyrimidin...;PYRIMIDINE, 2-(CHLOROMETHYL)-;pyrimidin-2-yl-methyl chloride;Pyrimidine, 2-(chloromethyl)- (9CI);2-(ChloroMethyl)pyriMidine(HCl ForM);2-(Chloromethyl)pyrimidine(HCl salt form)
CBNumber: CB9379246
Molecular Formula: C5H5ClN2
Formula Weight: 128.56
MOL File: 54198-88-8.mol

More

Less

2-(Chloromethyl)pyrimidine Property

Boiling point:: 101-103 °C(Press: 26 Torr)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 0.43±0.13(Predicted)
form: liquid
color: Brown

More

Less

Safety

HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 068531
Product name: 2-(Chloromethyl)pyrimidine
Purity: >95%
Packaging: 1g
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: W6849
Product name: 2-(Chloromethyl)pyrimidine
Packaging: 1g
Price: $151
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-CM
Product name: 2-(Chloromethyl)pyrimidine
Packaging: 1g
Price: $159
Updated: 2021/12/16

Matrix Scientific

Product number: 068531
Product name: 2-(Chloromethyl)pyrimidine
Purity: >95%
Packaging: 5g
Price: $425
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-CM
Product name: 2-(Chloromethyl)pyrimidine
Packaging: 5G
Price: $493
Updated: 2021/12/16

More

Less

2-(Chloromethyl)pyrimidine Chemical Properties,Usage,Production

Synthesis

42839-09-8

54198-88-8

General procedure for the synthesis of 2-(chloromethyl)pyrimidine from 2-pyrimidine methanol: To a stirred solution of pyrimidin-2-ylmethanol (4.5 g, 40.90 mmol) in dichloromethane (DCM, 50 mL) was slowly added thionyl chloride (SOCl2, 10 mL) at 0 °C and protected by an inert atmosphere. The reaction mixture was gradually warmed to 50 °C and stirred continuously for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete conversion of the feedstock, the volatiles were removed by distillation under reduced pressure. The residue was quenched with ice-cold water and subsequently neutralized with saturated sodium bicarbonate (NaHCO3) solution and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography to afford 2-(chloromethyl)pyrimidine in brown liquid form (960 mg, 18% yield). The product was characterized as follows: 1H-NMR (DMSO-d6, 400 MHz): δ8.84 (d, 2H), 7.52 (t, 1H), 4.82 (s, 2H); Mass spectrometry (ESI): m/z 128.5 [M + 1]+; Liquid Chromatography-Mass Spectrometry (LC-MS) purity: 95.09% (column: Chromolith RP-18, 100×4.6 mm; retention time: 3.86 min; mobile phase: 5 mM NH4OAc/acetonitrile (ACN); flow rate: 0.8 mL/min); thin-layer chromatography (TLC) conditions: 70% ethyl acetate/hexane (Rf value: 0.6).

References

[1] Patent: WO2012/40230, 2012, A1. Location in patent: Page/Page column 81
[2] Patent: US4118567, 1978, A
[3] Patent: EP150984, 1991, B1
[4] Patent: US4826833, 1989, A
[5] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0509; 0510

2-(Chloromethyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(Chloromethyl)pyrimidine Suppliers

China 93 Europe 1 France 1 Germany 1 India 1 United Kingdom 4 United States 15 Global 116

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Anisyn, Inc.

Tel: --
Fax: --
Email: sales@anisyn.com
Country: United States
ProdList: 863
Advantage: 0

Paradigm Scientific, Inc.

Tel: --
Fax: --
Email: support@paradigmscientific.com
Country: United States
ProdList: 165
Advantage: 50

Precursor Chemicals, Inc.

Tel: --
Fax: --
Email: info@precursorchem.com
Country: United States
ProdList: 347
Advantage: 51

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Chemgenx, LLC

Tel: --
Fax: --
Country: United States
ProdList: 852
Advantage: 60

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

More

Less

View Lastest Price from 2-(Chloromethyl)pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(Chloromethyl)pyrimidine 54198-88-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

54198-88-8, 2-(Chloromethyl)pyrimidineRelated Search:

2-Chloro-5-chloromethylpyridine 2-Chloropyrimidine Chloromethyltrimethylsilane Chloromethane Pirimiphos-methyl Sulfamerazine tert-Butyldimethylsilyl chloride Pyrimidine Chloromethyl methyl ether 2-(CHLOROMETHYL)-6-METHYLPYRIMIDIN-4-OL 2-Chloromethyl-4,6-dimethoxypyrimidine 2-(CHLOROMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4-AMINE 4-CHLORO-2-CHLOROMETHYLQUINAZOLINE 4-CHLORO-2-(TRICHLOROMETHYL)QUINAZOLINE ETHYL 4-AMINO-2-(CHLOROMETHYL)-6-METHYLFURO[2,3-D]PYRIMIDINE-5-CARBOXYLATE 4-CHLORO-2-(DICHLOROMETHYL)-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE 6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE 2-(Chloromethyl)pyrimidine

PYRIMIDINE, 2-(CHLOROMETHYL)-

2-(CHLOROMETHYL)-PYRIMIDINE

Pyrimidine, 2-(chloromethyl)- (9CI)

2-(chloromethyl)pyrimidine(SALTDATA: HCl)

2-(Chloromethyl)pyrimidin...

2-chloroMrthyl pyriMidine

2-(ChloroMethyl)pyriMidine(HCl ForM)

2-Chlormethyl-pyrimidin

pyrimidin-2-yl-methyl chloride

EOS-62429

2-(Chloromethyl)pyrimidine(HCl salt form)

54198-88-8

PYRIMIDINE

Heterocycle-Pyrimidine series