ChemicalBook > CAS DataBase List > A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE

A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE

Product Name
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
CAS No.
165806-95-1
Chemical Name
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
Synonyms
MethanidylidyneazaniuM;A-TOSYL-(4-FLUOROBENZYL) ISOCYANIDE;Alpha-tosyl-(4-fluorobenzal)isocyanide;Alpha-Tosyl-(4-fluorobenzyl) isocyanide;a-(p-Toluenesulfonyl)-4-fluorobenzylison;1-fluoro-4-(isocyano(tosyl)methyl)benzene;[1-(4-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE;a-(p-Toluenesulfonyl)-4-fluorobezylisonitrile;α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile;A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
CBNumber
CB9382376
Molecular Formula
C15H12FNO2S
Formula Weight
289.32
MOL File
165806-95-1.mol
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A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Property

Melting point:
>89°C (dec.)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Light Orange
InChI
InChI=1S/C15H12FNO2S/c1-11-3-9-14(10-4-11)20(18,19)15(17-2)12-5-7-13(16)8-6-12/h3-10,15H,1H3
InChIKey
UXCQPEDHCCJBNL-UHFFFAOYSA-N
SMILES
C(C1C=CC(F)=CC=1)([N+]#[C-])S(C1C=CC(C)=CC=1)(=O)=O
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Safety

Hazard Codes 
Xi
HS Code 
2930909899
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
P768818
Product name
α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile
Packaging
100mg
Price
$75
Updated
2021/12/16
TRC
Product number
P768818
Product name
α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile
Packaging
1g
Price
$500
Updated
2021/12/16
SynQuest Laboratories
Product number
8763-3-X0
Product name
alpha-[(4-Methylphenyl)sulfonyl]-4-fluorobenzylisonitrile
Packaging
5G
Price
$402
Updated
2021/12/16
Apolloscientific
Product number
PC8908
Product name
(4-Fluorophenyl)(isocyano)methyl4-methylphenylsulphone
Purity
98%
Packaging
10g
Price
$474
Updated
2021/12/16
Matrix Scientific
Product number
071803
Product name
Alpha-Tosyl-(4-fluorobenzyl) isocyanide
Purity
95+%
Packaging
5g
Price
$700
Updated
2021/12/16
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A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Chemical Properties,Usage,Production

Uses

Alpha-(p-toluenesulfonyl)-4-fluorobenzylisonitrile is a useful reagent for the development of DNA-compatible method for novel functionalized imidazoles.

Synthesis

165806-94-0

165806-95-1

4-Fluorophenyl-toluenesulfonylmethylformamide (2.01 g, 6.25 mmol) was used as the raw material, which was dissolved in DME (32 mL) and cooled to -10 °C. POCl3 (1.52 mL, 16.3 mmol) and triethylamine (4.6 mL, 32.6 mmol, dissolved in DME 3 mL) were added sequentially while keeping the internal temperature below -5 °C. The reaction mixture was slowly warmed to room temperature over 1 h and subsequently poured into water and extracted with EtOAc. The organic phase was washed with saturated aqueous NaHCO3, dried over Na2SO4 and concentrated. The residue was ground with petroleum ether and filtered to give α-tosyl(4-fluorobenzyl)isonitrile (1.7 g, 90% yield).1H NMR (CDCl3) δ 7.63 (d, 2H), 7.33 (m, 4H), 7.10 (t, 2H), 5.60 (s, 1H), 2.50 (s, 3H).

References

[1] Patent: US6046208, 2000, A
[2] Patent: US5658903, 1997, A
[3] Patent: US5716955, 1998, A
[4] Patent: US5739143, 1998, A
[5] Patent: US5756499, 1998, A

A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Suppliers

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View Lastest Price from A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE 165806-95-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
2000
Release date
2025-09-25
Shaanxi Dideu New Materials Co. Ltd
Product
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE 165806-95-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-07-04
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
A-TOSYL-(4-FLUOROBENZYL) ISOCYANIDE 165806-95-1
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-27

165806-95-1, A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILERelated Search:

A-TOSYL-(4-CHLOROBENZYL) ISOCYANIDE [1-(3-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE [1-(2-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE (1-PHENYL-1-TOSYL)METHYL ISOCYANIDE α-Tosyl-(2,4-difluorobenzyl)isocyanide A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE METHYL ISOCYANIDE PHENYLSULFONYLMETHYL ISOCYANIDE 4-FLUOROBENZYLISOCYANIDE 4-FLUOROBENZYL PHENYL SULFIDE 1-METHYL-1-TOSYLMETHYL ISOCYANIDE 2-CHLORO-4-FLUORO-1-[ISOCYANO-(TOLUENE-4-SULFONYL)-METHYL]-BENZENE

  • A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
  • A-TOSYL-(4-FLUOROBENZYL) ISOCYANIDE
  • ALPHA-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
  • ALPHA-(P-TOLUENESULFONYL)-4-FLUOROBEZYLISONITRILE
  • [1-(4-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE
  • α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile
  • (4-Fluorophenyl)(isocyano)methyl 4-methylphenyl sulphone
  • Benzene,1-fluoro-4-[isocyano[(4-Methylphenyl)sulfonyl]Methyl]-
  • Alpha-tosyl-(4-fluorobenzal)isocyanide
  • alpha-[(4-Methylphenyl)sulphonyl]-4-fluoroBenzylisonitrile
  • 1-{[(4-fluorophenyl)Methane]sulfonyl}-4-Methylbenzene
  • MethanidylidyneazaniuM
  • Alpha-Tosyl-(4-fluorobenzyl) isocyanide
  • 4-Fluoro-alpha-(toluene-4-sulphonyl)benzyl isocyanide, (4-Fluorophenyl)(isocyano)methyl p-tolyl sulphone
  • a-(p-Toluenesulfonyl)-4-fluorobezylisonitrile
  • 1-fluoro-4-(isocyano(tosyl)methyl)benzene
  • 1-[(4-fluorophenyl)(isocyano)Methanesulfonyl]-4- Methylbenzene
  • α-(p-toluenesulfonyl)-4-fluorobenzylisocyanide
  • alpha-[(4-Methylphenyl)sulfonyl]-4-fluorobenzylisonitrile
  • a-(p-Toluenesulfonyl)-4-fluorobenzylison
  • ^a-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile,97%
  • A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE ISO 9001：2015 REACH
  • 1-fluoro-4-[isocyano(4-methylbenzenesulfonyl)methyl]benzene
  • 1-[(4-fluorophenyl)-isocyanomethyl]sulfonyl-4-methylbenzene
  • A-(P-Toluenesulfonyl)-4-fluorobenzylisocyanide
  • 165806-95-1
  • C15H12FNO2S