ChemicalBook > CAS DataBase List > A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE

A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE

Product Name
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
CAS No.
165806-95-1
Chemical Name
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
Synonyms
MethanidylidyneazaniuM;A-TOSYL-(4-FLUOROBENZYL) ISOCYANIDE;Alpha-tosyl-(4-fluorobenzal)isocyanide;Alpha-Tosyl-(4-fluorobenzyl) isocyanide;a-(p-Toluenesulfonyl)-4-fluorobenzylison;1-fluoro-4-(isocyano(tosyl)methyl)benzene;[1-(4-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE;a-(p-Toluenesulfonyl)-4-fluorobezylisonitrile;α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile;A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
CBNumber
CB9382376
Molecular Formula
C15H12FNO2S
Formula Weight
289.32
MOL File
165806-95-1.mol
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A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Property

Melting point:
>89°C (dec.)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Light Orange
InChI
InChI=1S/C15H12FNO2S/c1-11-3-9-14(10-4-11)20(18,19)15(17-2)12-5-7-13(16)8-6-12/h3-10,15H,1H3
InChIKey
UXCQPEDHCCJBNL-UHFFFAOYSA-N
SMILES
C(C1C=CC(F)=CC=1)([N+]#[C-])S(C1C=CC(C)=CC=1)(=O)=O
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Safety

Hazard Codes 
Xi
HS Code 
2930909899
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
P768818
Product name
α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile
Packaging
100mg
Price
$75
Updated
2021/12/16
TRC
Product number
P768818
Product name
α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile
Packaging
1g
Price
$500
Updated
2021/12/16
Apolloscientific
Product number
PC8908
Product name
(4-Fluorophenyl)(isocyano)methyl4-methylphenylsulphone
Purity
98%
Packaging
1g
Price
$98
Updated
2021/12/16
AK Scientific
Product number
W3603
Product name
a-Tosyl-(4-fluorobenzyl)isocyanide
Packaging
1g
Price
$117
Updated
2021/12/16
SynQuest Laboratories
Product number
8763-3-X0
Product name
alpha-[(4-Methylphenyl)sulfonyl]-4-fluorobenzylisonitrile
Packaging
1g
Price
$157
Updated
2021/12/16
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A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Chemical Properties,Usage,Production

Uses

Alpha-(p-toluenesulfonyl)-4-fluorobenzylisonitrile is a useful reagent for the development of DNA-compatible method for novel functionalized imidazoles.

Synthesis

165806-94-0

165806-95-1

4-Fluorophenyl-toluenesulfonylmethylformamide (2.01 g, 6.25 mmol) was used as the raw material, which was dissolved in DME (32 mL) and cooled to -10 °C. POCl3 (1.52 mL, 16.3 mmol) and triethylamine (4.6 mL, 32.6 mmol, dissolved in DME 3 mL) were added sequentially while keeping the internal temperature below -5 °C. The reaction mixture was slowly warmed to room temperature over 1 h and subsequently poured into water and extracted with EtOAc. The organic phase was washed with saturated aqueous NaHCO3, dried over Na2SO4 and concentrated. The residue was ground with petroleum ether and filtered to give α-tosyl(4-fluorobenzyl)isonitrile (1.7 g, 90% yield).1H NMR (CDCl3) δ 7.63 (d, 2H), 7.33 (m, 4H), 7.10 (t, 2H), 5.60 (s, 1H), 2.50 (s, 3H).

References

[1] Patent: US6046208, 2000, A
[2] Patent: US5658903, 1997, A
[3] Patent: US5716955, 1998, A
[4] Patent: US5739143, 1998, A
[5] Patent: US5756499, 1998, A

A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE Suppliers

China 75 China Hong Kong 1 Germany 2 India 4 United Kingdom 5 United States 14 Global 101
Alfa Aesar
Tel
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Fax
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Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
CHEMSWORTH
Tel
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Fax
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Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE 165806-95-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
2000
Release date
2025-09-25
Shaanxi Dideu New Materials Co. Ltd
Product
A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE 165806-95-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-07-04
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
A-TOSYL-(4-FLUOROBENZYL) ISOCYANIDE 165806-95-1
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-27

165806-95-1, A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILERelated Search:

A-TOSYL-(4-CHLOROBENZYL) ISOCYANIDE [1-(3-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE [1-(2-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE (1-PHENYL-1-TOSYL)METHYL ISOCYANIDE α-Tosyl-(2,4-difluorobenzyl)isocyanide A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE METHYL ISOCYANIDE PHENYLSULFONYLMETHYL ISOCYANIDE 4-FLUOROBENZYLISOCYANIDE 4-FLUOROBENZYL PHENYL SULFIDE 1-METHYL-1-TOSYLMETHYL ISOCYANIDE 2-CHLORO-4-FLUORO-1-[ISOCYANO-(TOLUENE-4-SULFONYL)-METHYL]-BENZENE

  • A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
  • A-TOSYL-(4-FLUOROBENZYL) ISOCYANIDE
  • ALPHA-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE
  • ALPHA-(P-TOLUENESULFONYL)-4-FLUOROBEZYLISONITRILE
  • [1-(4-FLUOROPHENYL)-1-TOSYL]METHYL ISOCYANIDE
  • α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile
  • (4-Fluorophenyl)(isocyano)methyl 4-methylphenyl sulphone
  • Benzene,1-fluoro-4-[isocyano[(4-Methylphenyl)sulfonyl]Methyl]-
  • Alpha-tosyl-(4-fluorobenzal)isocyanide
  • alpha-[(4-Methylphenyl)sulphonyl]-4-fluoroBenzylisonitrile
  • 1-{[(4-fluorophenyl)Methane]sulfonyl}-4-Methylbenzene
  • MethanidylidyneazaniuM
  • Alpha-Tosyl-(4-fluorobenzyl) isocyanide
  • 4-Fluoro-alpha-(toluene-4-sulphonyl)benzyl isocyanide, (4-Fluorophenyl)(isocyano)methyl p-tolyl sulphone
  • a-(p-Toluenesulfonyl)-4-fluorobezylisonitrile
  • 1-fluoro-4-(isocyano(tosyl)methyl)benzene
  • 1-[(4-fluorophenyl)(isocyano)Methanesulfonyl]-4- Methylbenzene
  • α-(p-toluenesulfonyl)-4-fluorobenzylisocyanide
  • alpha-[(4-Methylphenyl)sulfonyl]-4-fluorobenzylisonitrile
  • a-(p-Toluenesulfonyl)-4-fluorobenzylison
  • ^a-(p-Toluenesulfonyl)-4-fluorobenzylisonitrile,97%
  • A-(P-TOLUENESULFONYL)-4-FLUOROBENZYLISONITRILE ISO 9001：2015 REACH
  • 1-fluoro-4-[isocyano(4-methylbenzenesulfonyl)methyl]benzene
  • 1-[(4-fluorophenyl)-isocyanomethyl]sulfonyl-4-methylbenzene
  • A-(P-Toluenesulfonyl)-4-fluorobenzylisocyanide
  • 165806-95-1
  • C15H12FNO2S