ChemicalBook > CAS DataBase List > 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE

4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE

Product Name
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
CAS No.
106691-21-8
Chemical Name
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
Synonyms
AKOS 92593;4-Chloro-6-Methylthieno[2...;4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE;Thieno[2,3-d]pyrimidine, 4-chloro-6-methyl-;4-chloro-6-methylthieno[2,3-d]pyrimidine(SALTDATA: FREE);4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB9385175
Molecular Formula
C7H5ClN2S
Formula Weight
184.65
MOL File
106691-21-8.mol
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4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Property

Melting point:
88-91℃ (sublm)
Boiling point:
301.3±37.0 °C(Predicted)
Density 
1.445±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.56±0.40(Predicted)
Appearance
light yellow solid
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Safety

Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C367573
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
X3464
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
10g
Price
$1269
Updated
2021/12/16
Oakwood
Product number
021442
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
25g
Price
$1750
Updated
2021/12/16
AK Scientific
Product number
X3464
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
2.5g
Price
$467
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0320069
Product name
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
Purity
95.00%
Packaging
5MG
Price
$500.03
Updated
2021/12/16
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4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

108831-66-9

106691-21-8

GENERAL METHOD: A mixture of 6-methyl-3H-thieno[2,3-d]pyrimidin-4-one (0.01 mol), phosphorus trichloride (11 mL), and phosphorus pentachloride (1.5 g) was rapidly heated to 105°C and the reaction was carried out at reflux for 5-6 hours. After completion of the reaction, excess solvent was removed by distillation under reduced pressure. The crude product was dissolved in dichloromethane (12 mL) and neutralized with cold sodium hydroxide solution (0.5 N). The organic phase was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized with isopropanol to afford the target product 4-chloro-6-methylthieno[2,3-d]pyrimidine in 80% yield.

References

[1] Pharmaceutical Chemistry Journal, 1987, vol. 21, # 2, p. 126 - 129
[2] Khimiko-Farmatsevticheskii Zhurnal, 1987, vol. 21, # 2, p. 197 - 200
[3] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 148 - 160
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 2, p. 305 - 308
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 3, p. 870 - 876

4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Suppliers

China 45 Germany 1 India 1 Switzerland 1 United Kingdom 2 United States 8 Global 58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Synthfine Chemical Co.,Ltd
Tel
15921303235
Fax
QQ489466966
Email
sales@synthfine.com
Country
China
ProdList
1043
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58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
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View Lastest Price from 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE 106691-21-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-11-24
Career Henan Chemical Co
Product
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE 106691-21-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-14

106691-21-8, 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINERelated Search:

4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2,5,6-TRIMETHYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-6-ETHYLTHIENO[2,3-D]PYRIMIDINE 7-TERT-BUTYL-4-CHLORO-5,6,7,8-TETRAHYDRO-BENZO[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-5,6,7,8-TETRAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-6-PHENYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-PYRIDIN-3-YL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLOROTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-2,5-DIMETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE 4-CHLORO-2-METHYL-6-PHENYL-THIENO[2,3-D]PYRIMIDINE 4-CHLORO-6-METHYL-2,3-DIHYDRO-1H-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE 4-CHLORO-2-ETHYL-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-ETHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

  • 4-chloro-6-methylthieno[2,3-d]pyrimidine(SALTDATA: FREE)
  • 4-Chloro-6-Methylthieno[2...
  • AKOS 92593
  • 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
  • Thieno[2,3-d]pyrimidine, 4-chloro-6-methyl-
  • 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
  • 106691-21-8