ChemicalBook > CAS DataBase List > SUC-ALA-ALA-PRO-PHE-PNA

SUC-ALA-ALA-PRO-PHE-PNA

Product Name
SUC-ALA-ALA-PRO-PHE-PNA
CAS No.
70967-97-4
Chemical Name
SUC-ALA-ALA-PRO-PHE-PNA
Synonyms
SAAPNA;SUC-AAPF-PNA;Cathepsin G substrate;70967-97-4/107409-54-1;SUC-ALA-ALA-PRO-PHE-PNA;Cathepsin G Substrate I;N-SUCCINYL-ALA-ALA-PRO-PHE-PNA;SUC-ALA-ALA-PRO-PHE-PNA USP/EP/BP;SUC-ALA-ALA-PRO-PHE-PARANITROANILIDE;CATHEPSIN G SUBSTRATE I, COLORIMETRIC
CBNumber
CB9399626
Molecular Formula
C30H36N6O9
Formula Weight
624.64
MOL File
70967-97-4.mol
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SUC-ALA-ALA-PRO-PHE-PNA Property

storage temp. 
-20°C
solubility 
DMF: 25 mg/mL, clear, light yellow
form 
White to off-white solid
color 
White to off-white
BRN 
4289896
Sequence
{Suc}-Ala-Ala-Pro-Phe-{pNA}
InChIKey
LKDMKWNDBAVNQZ-UHYNAWRVNA-N
SMILES
N1(CCC[C@H]1C(=O)N[C@H](C(=O)NC1=CC=C([N+]([O-])=O)C=C1)CC1=CC=CC=C1)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(=O)O |&1:4,8,30,35,r|
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7388
Product name
N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide
Packaging
25mg
Price
$100
Updated
2025/07/31
Sigma-Aldrich
Product number
573462
Product name
N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide
Packaging
25mg
Price
$85.1
Updated
2025/07/31
Cayman Chemical
Product number
14993
Product name
Suc-AAPF-pNA
Purity
≥95%
Packaging
10mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
14993
Product name
Suc-AAPF-pNA
Purity
≥95%
Packaging
25mg
Price
$78
Updated
2024/03/01
Sigma-Aldrich
Product number
S7388
Product name
N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide
Packaging
100mg
Price
$371
Updated
2025/07/31
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SUC-ALA-ALA-PRO-PHE-PNA Chemical Properties,Usage,Production

Description

Suc-AAPF-pNA is a chromogenic substrate that can be cleaved by cathepsin G (Km = 1.7 mM), subtilisins, chymotrypsin (Km = 60 μM), chymase (Km = 4 mM), and cyclophilin, but not neutrophil elastase. Release of p-nitroanilide is monitored at 405-410 nm. This substrate can be used for inhibitor screening and kinetic analysis.

Uses

N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide has been used as a substrate to determine chymotrypsin activity.

Biochem/physiol Actions

N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide is a substrate for subtilisin and proteases.

References

[1] K. NAKAJIMA. Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.[J]. The Journal of Biological Chemistry, 1979, 107 1: 4027-4032. DOI: 10.1016/s0021-9258(18)50690-6
[2] J ERMOLIEFF. Heparin protects cathepsin G against inhibition by protein proteinase inhibitors.[J]. The Journal of Biological Chemistry, 1994, 269 47: 29502-29508.
[3] JAMES L. KOFRON. Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay[J]. Biochemistry Biochemistry, 1991, 30 25: 6127-6134. DOI: 10.1021/bi00239a007
[4] H NAKAKUBO. Secretory production of recombinant human chymase as an active form in Pichia pastoris.[J]. Yeast, 2000, 16 4: 315-323. DOI: 10.1002/1097-0061(20000315)16:4<315::aid-yea527>3.0.co;2-4

SUC-ALA-ALA-PRO-PHE-PNA Preparation Products And Raw materials

Raw materials

Preparation Products

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SUC-ALA-ALA-PRO-PHE-PNA Suppliers

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70967-97-4, SUC-ALA-ALA-PRO-PHE-PNARelated Search:

SUC-ALA-ALA-ALA-PNA N,N'-Ethylenebis(stearamide) 5-METHYL-N,N-DIMETHYLTRYPTAMINE L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- EC 3.4.22.1 SUC-GLY-PHE-GLY-PNA CHYMOTRYPSIN SUBSTRATE I, COLORIMETRIC SUC-ALA-ALA-PRO-VAL-AMC Chymotrypsin Substrate II, Fluorogenic SUC-ALA-PRO-PNA SUC-ALA-PHE-LYS-AMC SUC-PHE-PRO-PHE-PNA Suc-Phe-Gly-Leu-βNA SUC-PHE-ALA-ALA-PHE-PNA SUC-ALA-ALA-VAL-AMC SUC-ALA-ALA-PRO-NVA-PNA SUC-VAL-PRO-PHE-SBZL SUC-PHE-LEU-PHE-SBZL

  • N-Succinyl-Ala-Ala-Pro-Phe 4-nitroanilide
  • succinyl-alanyl-alanyl-prolyl-phenylalanine-4-nitroanilide
  • N-succinyl-alanyl-alanyl-prolyl-phenylanaline nitroanilide
  • N-Succinyl-Ala-Ala-Pro-Phe-pNA, N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide
  • Cathepsin G Substrate I
  • N-SUCCINYL-L-ALANYL-L-ALANYL-L-PROLYL-L-PHENYLALANINE 4-NITROANILIDE
  • N-SUCCINYL-ALA-ALA-PRO-PHE-PNA
  • N-SUCCINYL-ALA-ALA-PRO-PHE P-NITROANILIDE
  • Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide - CAS 70967-97-4 - Calbiochem
  • SAAPNA
  • N-Succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine p-nitroanilide
  • Cathepsin G substrate
  • CATHEPSIN G SUBSTRATE I, COLORIMETRIC
  • SUCCINYL-L-ALANYL-L-ALANYL-L-PROLYL-L-PHENYLALANINE-4-NITROANILIDE
  • SUCCINYL-ALA-ALA-PRO-PHE-P-NITROANILIDE
  • SUC-ALA-ALA-PRO-PHE-PARANITROANILIDE
  • SUC-ALA-ALA-PRO-PHE-PNA
  • SUC-AAPF-PNA
  • SUC-ALA-ALA-PRO-PHE-PNA USP/EP/BP
  • 70967-97-4/107409-54-1
  • N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-phenylalaninamide
  • Succinyl-Ala-Ala-Pro-Phe-<i>p</i>-nitroanilide
  • L-Phenylalaninamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-
  • 70967-97-4
  • C30H36N6O9
  • Chymotrypsin, alpha
  • Enzyme Substrates
  • Enzymes, Inhibitors, and Substrates
  • Substrates
  • Substrates by Enzyme
  • Apoptosis and Cell Cycle
  • Cathepsins and Granzymes
  • Cathepsin G
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Biochemicals and Reagents
  • BioChemical
  • amino
  • ADC Linker