ChemicalBook > CAS DataBase List > alpha-Lobeline hydrochloride

alpha-Lobeline hydrochloride

Product Name
alpha-Lobeline hydrochloride
CAS No.
134-63-4
Chemical Name
alpha-Lobeline hydrochloride
Synonyms
Lobelin Hydrochlorde;LOBELINE HYDROCHLORIDE;(-)-id;a-Lobeline;A-LOBELINE HCL;(-)-LOBELINE HCL;LOBELINE HCL, A-;Einecs 205-150-2;ALPHA-LOBELIN HCL;Lobeline HCl salt
CBNumber
CB9404885
Molecular Formula
C22H28ClNO2
Formula Weight
373.92
MOL File
134-63-4.mol
More
Less

alpha-Lobeline hydrochloride Property

Melting point:
183-185 °C (dec.)(lit.)
alpha 
D20 -43° (c = 2)
refractive index 
-57.5 ° (C=1, H2O)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 25 mg/mL
form 
powder
color 
white to off-white
optical activity
[α]20/D 56.8°, c = 2 in H2O
Merck 
14,5551
BRN 
3920196
LogP
3.610 (est)
CAS DataBase Reference
134-63-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
23/25
Safety Statements 
36/37/39-45
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
3
RTECS 
OJ8490100
F 
8
HazardClass 
6.1(b)
PackingGroup 
III
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000112
Product name
Lobeline hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000112
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
141879
Product name
(?)-Lobeline hydrochloride
Purity
98%
Packaging
1g
Price
$304
Updated
2024/03/01
Cayman Chemical
Product number
29526
Product name
(–)-Lobelin (hydrochloride)
Packaging
250mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
29526
Product name
(–)-Lobelin (hydrochloride)
Packaging
500mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
29526
Product name
(–)-Lobelin (hydrochloride)
Packaging
1g
Price
$143
Updated
2024/03/01
More
Less

alpha-Lobeline hydrochloride Chemical Properties,Usage,Production

Description

(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (Ki = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.

Chemical Properties

White to Off-White Solid

Uses

A neuronal nicotinic acetylcholine receptor agonist. A respiratory stimulant

Uses

A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.

Biological Activity

High affinity nicotinic receptor ligand, with a K i value of 4.4 nM in rat brain.

in vitro

clastogenicity of lobeline and possible interactions between lobeline and ethyl alcohol were investigated in a mutagen-sensitivity assay on cultures of human lymphoblastoid cell lines. lobeline alone was not clastogenic, but there was a marked increase in genetic damage resulting from a coclastogenic interaction between lobeline and ethyl alcohol. [5]

in vivo

male c57bl/6j mice were individually housed and acclimatized to 10% alcohol. lobeline is a partial nicotinic agonist that attenuates alcohol consumption and preference in male c57bl/6j mice. [3] cf-1 male mice received an intraperitoneal injection of lobeline (5 or 10mg/kg). lobeline did not show genotoxic or mutagenic effects and did not increase the ethanol-induced genotoxic effects in blood. lobeline also protected blood cells against oxidative damage induced by hydrogen peroxide. [4]

alpha-Lobeline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

alpha-Lobeline hydrochloride Suppliers

Americas 1 Belgium 1 Canada 1 China 158 Europe 1 France 2 Germany 6 India 7 Japan 1 Switzerland 3 United Kingdom 13 United States 35 Venezuela 1 Global 230
Suzhou Zhongke New Drug Basket Biomedical Technology Co., Ltd.
Tel
13616278204
Email
shenlei@supharm.cn
Country
China
ProdList
64
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17988
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1937
Advantage
57
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3924
Advantage
50
GIHI CHEMICALS CO.,LTD
Tel
0086-571-86217390
Fax
0086-571-86217391
Email
Sales@gihichem.com
Country
China
ProdList
861
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16687
Advantage
50
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Fax
021-50426030
Email
2630597085@qq.com
Country
China
ProdList
1889
Advantage
55
Nanjing Chempioneer Pharmaceutical Co., Ltd.
Tel
18068075658
Fax
-
Email
sales@chempioneer.com
Country
China
ProdList
1811
Advantage
58
Shanghai Synchem Pharma Co., ltd
Tel
021-61984905-1 18016477331
Email
synchempharma@aliyun.com
Country
China
ProdList
6454
Advantage
55
Beijing NuoqiYa Biotechnology Co., Ltd.
Tel
4000-819-385 010-62329685 13718666987
Fax
010-62340519
Country
China
ProdList
1971
Advantage
55
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9030
Advantage
60
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10457
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1993
Advantage
55
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1940
Advantage
55
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1831
Advantage
55
Wuhan Magic Biological Technology Co., Ltd.
Tel
18872289958、027-52304252、3400508168
Fax
027-52304252
Email
3400508168@qq.com
Country
China
ProdList
1910
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3978
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28822
Advantage
58
Guangzhou LES biological Technology Co.,Ltd.
Tel
13672434928
Fax
-
Email
3307355104@qq.com
Country
China
ProdList
3650
Advantage
58
Shanghai Standard Technology Co.,Ltd.
Tel
021-57127007-6622 15618937986
Fax
+86 (21) 5132-0077
Email
zhaok@nature-standard.com
Country
China
ProdList
3920
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15503
Advantage
58
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
021-58958618
Email
xiaoyangw@gmail.com
Country
China
ProdList
2129
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
6912
Advantage
58
Nanjing Digger Medical Technology Co. Ltd.
Tel
025-025-51191215 18013836722
Fax
025-51191215
Email
2399235533@qq.com
Country
China
ProdList
4933
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55791
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1991
Advantage
58
Suzhou Greet Medical Technology Co., Ltd.
Tel
0512-62384765 13701544574
Email
renwei@great-chem.cn
Country
China
ProdList
67
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10523
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418671
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34572
Advantage
58
More
Less

View Lastest Price from alpha-Lobeline hydrochloride manufacturers

Wuhan Monad Medicine Tech Co.,LTD
Product
Lobeline hydrochloride 134-63-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%min
Supply Ability
5000
Release date
2021-04-16
Dideu Industries Group Limited
Product
alpha-Lobeline hydrochloride 134-63-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28
Career Henan Chemical Co
Product
alpha-Lobeline hydrochloride 134-63-4
Price
US $1.00/KG
Min. Order
1g
Purity
98%
Supply Ability
200kgs
Release date
2020-01-09

134-63-4, alpha-Lobeline hydrochlorideRelated Search:

Diethylstilbestrol N-Ethylmethylamine Lobeline Methyl salicylate 1-AdaMantanethylaMine 2'-Hydroxyacetophenone Kresoxim-methyl PHENYL VALERATE Thiophanate-methyl Topotecan hydrochloride Tribenuron methyl α-Lipoic Acid 3,4-Dihydroxyacetophenone 1-Hydroxyethylidene-1,1-diphosphonic acid 4-Ethyl-5-fluoro-6-hydroxypyrimidine 3'-Hydroxyacetophenone CHLOROPHOSPHONAZO III 3-Nitroacetophenone

  • (-)-id
  • 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor
  • 2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone
  • Lobelinhydrochloride
  • 2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone
  • Lobelin Hydrochlorde
  • 2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL
  • 2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE
  • 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenyl-ethyl]-1-methyl-2-piperidyl]-1-phenyl-ethanone hydrochloride
  • [2-[(2R,6S)-6-[(2S)-2-HYDROXYPHENETHYL]]-1-METHYL-2-PIPERIDYL]ACETOPHENONE HYDROCHLORIDE
  • (-)-LOBELINE HCL
  • LOBELINE HCL, A-
  • (-)-LOBELINE HYDROCHLORIDE
  • LOBELINE HYDROCHLORIDE
  • L-LOBELINE HYDROCHLORIDE
  • A-LOBELINE HCL
  • A-LOBELINE, HYDROCHLORIDE
  • ALPHA-LOBELINE HYDROCHLORIDE
  • ALPHA-LOBELIN HCL
  • 2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride
  • 2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone, L-Lobeline, Hydrochloride
  • a-Lobeline
  • Lobeline HCl salt
  • Apolipoprotein B (LDL), Sheep anti-Human, Guinea pig, Swine (NO X w/Bovine, Horse, Dog, Cat, Rabbit, Chicken, Goat, Mouse, Rat)
  • 2-[(6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenylethanone
  • a-Lobeline Hydrochloride (L-Lobeline hydrochloride
  • 2-[6-(beta-Hydroxyphenylethyl)-1-methyl-2-piperidinyl]acetophenone hydrochloride
  • Acetophenone, 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-, hydrochloride, (-)-
  • Einecs 205-150-2
  • Ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride
  • Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride, (2R-(2alpha,6alpha(S*))-
  • α-Lobeline Hydrochcloride
  • 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenonehydrochloride
  • Lobeline hydrochloride ,99%
  • α-Lobeline hydrochloride,2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride, ()-Lobeline hydrochloride
  • 2-[1-chloro-6-(2-hydroxy-2-phenylethyl)-1-Methyl-1$l^{5}-piperidin-2-yl]-1-phenylethan-1-one
  • 2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-Methyl-2-piperidinyl]-1-phenylethanone Hydrochloride
  • 2-[6-(2-hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride
  • (-)-Lobeline hydrochloride, 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride
  • α-Lobeline hydrochloride, L-Lobeline hydrochloride
  • 2-(6-(2-Hydroxy-2-phenylethyl)-1-Methylpiperidin-2-yl)-1-phenylethanone hydrochloride
  • Lobeline hydrochloride CRS
  • 2-((2R,6S)-6-((S)-2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one hydrochloride
  • alpha-Lobeline hydrochloride USP/EP/BP
  • (-)-a-Lobeline Hydrochloride
  • Lobeline hydrochloride (C-07475)
  • α-Lobeline hydrochloride
  • Lobelinehydrochlonide
  • α-Lobeline Hydrochcloride
  • (-)-Lobeline hydrochloride
  • (–)-Lobelin (hydrochloride)
  • 2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride
  • (?)-Lobeline hydrochloride
  • 134-63-4
  • C22H27NO2HCl
  • Building Blocks
  • Asymmetric Synthesis
  • Chiral Building Blocks