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ChemicalBook > CAS DataBase List > cis-1,2-Diaminocyclohexane

cis-1,2-Diaminocyclohexane

Description References
Product Name
cis-1,2-Diaminocyclohexane
CAS No.
1436-59-5
Chemical Name
cis-1,2-Diaminocyclohexane
Synonyms
cis<;(2-aminocyclohexyl)amine;cis-1,2-Cyclohexandiamine;CIS-1,2-CYCLOHEXANEDIAMINE;CIS-1,2-DIAMINOCYCLOHEXANE;meso-1,2-Cyclohexanediamine;cis-Cyclohexane-1,2-diamine;1,2-DIAMINOCYCLOHEXANE, cis;1,2-Cyclohexanediamine, cis-;(R)(S)-1,2-Diaminocyclohexane
CBNumber
CB9412187
Molecular Formula
C6H14N2
Formula Weight
114.19
MOL File
1436-59-5.mol
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cis-1,2-Diaminocyclohexane Property

Melting point:
8°C
Boiling point:
92-93 °C/18 mmHg (lit.)
Density 
0.952 g/mL at 25 °C (lit.)
vapor pressure 
0.4 mm Hg ( 20 °C)
refractive index 
n20/D 1.493(lit.)
Flash point:
161 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
Water Solubility 
Completely miscible in water
form 
Low Melting Solid
pka
9.93(at 20℃)
color 
Brown
InChIKey
SSJXIUAHEKJCMH-OLQVQODUSA-N
CAS DataBase Reference
1436-59-5(CAS DataBase Reference)
NIST Chemistry Reference
cis-1,2-Cyclohexanediamine(1436-59-5)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
F 
10-34
HazardClass 
8
PackingGroup 
II
HS Code 
29213000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C1463
Product name
cis-1,2-Cyclohexanediamine
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$72
Updated
2024/03/01
TCI Chemical
Product number
C1463
Product name
cis-1,2-Cyclohexanediamine
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$210
Updated
2024/03/01
TRC
Product number
D416224
Product name
cis-1,2-Diaminocyclohexane
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
D416224
Product name
cis-1,2-Diaminocyclohexane
Packaging
500mg
Price
$55
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0014089
Product name
CIS-1, 2-DIAMINO CYCLOHEXANE
Purity
95.00%
Packaging
1G
Price
$686.54
Updated
2021/12/16
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cis-1,2-Diaminocyclohexane Chemical Properties,Usage,Production

Description

cis-1, 2-Diaminocyclohexane is a cyclohexane derivative. It can be used for the synthesis of platinum complexes with high antitumor activity. It can also be used for the preparation of multidentate ligands for uranyl and transition metal complexation. Moreover, it can also be used as the base for the manufacturing of titanium salalen catalyst. Its derivative also has the potential to be manufactured into a potent factor Xa inhibitor. 

References

Khokhar, Abdul R., et al. "Chemical and Biological Studies on a Series of Novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-Diaminocyclohexane)platinum(IV) Carboxylate Complexes." Journal of Medicinal Chemistry 40.1(1997):112.
Mauldin, S. K., et al. "High-performance liquid chromatographic separation of platinum complexes containing the cis-1,2-diaminocyclohexane carrier ligand. " Analytical Biochemistry157.1 (1986):129-43.
Berkessel, A, et al. "Titanium salalen catalysts based on cis-1,2-diaminocyclohexane: enantioselective epoxidation of terminal non-conjugated olefins with H2O2. " Angewandte Chemie 52.32(2013):8467-71.
Yoshikawa, K, et al. "Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties. " Bioorganic & Medicinal Chemistry 17.24(2009):8221.
http://www.sigmaaldrich.com/catalog/product/aldrich/307467?lang=en&region=US

Chemical Properties

Clear colorless liquid

Uses

cis-1,2-Diaminocyclohexane was used in the synthesis of platinum complexes that have high antitumor activity.It was also used in the synthesis of multidentate ligands for uranyl and transition metal complexation.

General Description

cis-1,2-Diaminocyclohexane perturbed the spectrum of free pyrroloquinoline quinone (PQQ), a covalently linked form of which is the carbonyl cofactor of lysyl oxidase and also induced similar changes in the spectrum of lysyl oxidase.

Purification Methods

Dry the diamine over solid KOH and distil it in a vacuum. It is a strong base, keep away from CO2, store in the dark under N2. [Beilstein 13 IV 1.]

cis-1,2-Diaminocyclohexane Preparation Products And Raw materials

Raw materials

Sodium azide 3-Methylbenzoyl chloride Palladium Phthalic acid Thionyl chloride

Preparation Products

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View Lastest Price from cis-1,2-Diaminocyclohexane manufacturers

Shanghai UCHEM Inc.
Product
cis-1,2-Diaminocyclohexane 1436-59-5
Price
US $31.00-274.00/g
Min. Order
5g
Purity
0.98
Supply Ability
25kg
Release date
2023-12-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
cis-1,2-Diaminocyclohexane 1436-59-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
cis-1,2-Diaminocyclohexane 1436-59-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1436-59-5, cis-1,2-DiaminocyclohexaneRelated Search:

(+/-)-trans-1,2-Diaminocyclohexane 1,2-Cyclohexanediol trans-1,4-Diaminocyclohexane 1,2-Diaminocyclohexane 1,2-Cyclohexanedione Hexamethylenediamine CIS-1,2,3,6-TETRAHYDROPHTHALIMIDE CIS,CIS-9,12-OCTADECADIENOL cis-3-Hydroxycyclobutanecarboxylic acid cis-4-Hydroxy-D-proline cis-1,4-Dichloro-2-butene cis-Hexahydrophthalic acid CIS-CYCLOPENTANE-1,2-DICARBOXYLIC ACID CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE cis-1,3-cyclohexanedicarboxylic acid (1S,3R)-cyclopentane-1,3-dicarboxylic acid CIS-2-PHENYL-1,3-DIOXAN-5-OL CIS-1,4-DIACETOXY-2-BUTENE

  • (R)(S)-1,2-Diaminocyclohexane
  • 1,2-Cyclohexanediamine, cis-
  • cis-1,2-Cyclohexandiamine
  • meso-1,2-Cyclohexanediamine
  • CIS-1,2-DIAMINOCYCLOHEXANE
  • CIS-1,2-CYCLOHEXANEDIAMINE
  • (1R,2S)-1,2-Cyclohexanediamine
  • (±)-cis-1,2-Diaminocyclohexane,97%
  • (2-aminocyclohexyl)amine
  • cis-1,2-Diaminocyclohexane,cis-1,2-Cyclohexanediamine
  • (§1)-cis-1,2-Diaminocyclohexane, 97%
  • 1,2-CyclohexanediaMine,(1R,2S)-rel-
  • cis-1,2-DiaMinocyclohexane 97%
  • <i>cis</i>-1,2-Cyclohexanediamine
  • cis-Cyclohexane-1,2-diamine
  • (1R,2S)-cyclohexane-1,2-diaMine
  • 1,2-DIAMINOCYCLOHEXANE, cis
  • (1S,2R)-cyclohexane-1,2-diamine
  • cis-1,2-Cyclohexanediamine &gt
  • (Z)-1,1,1,4,4,4-hexafluorobut-2-ene, C4H2F6
  • <i>cis<
  • <i>cis</i>-1,2-Diaminocyclohexane
  • (±)-cis-1，2-Diaminocyclohexane
  • 1436-59-5
  • Organic Building Blocks
  • Nitrogen Compounds
  • Polyamines
  • Building Blocks