D-2-Phenylglycine

ChemicalBook > CAS DataBase List > D-2-Phenylglycine

D-2-Phenylglycine

Description Storage

Product Name: D-2-Phenylglycine
CAS No.: 875-74-1
Chemical Name: D-2-Phenylglycine
Synonyms: (R)-2-AMino-2-phenylacetic acid;D-PHENYLGLYCINE;D-(-)-PHENYLGLYCINE;H-D-PHG-OH;(2R)-2-amino-2-phenylacetic acid;ycine;D-Phg-OH;D-(-)-α-PhenyL;D-2-Phenylglyc;PHENYLGLYCINE-D
CBNumber: CB9413124
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 875-74-1.mol

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D-2-Phenylglycine Property

Melting point:: 302 °C (dec.)(lit.)
alpha: -156 º (c=1,1N HCl)
Boiling point:: 273.17°C (rough estimate)
Density: 1.2 g/cm3 (20℃)
vapor pressure: 0Pa at 25℃
refractive index: -158 ° (C=1, 1mol/L HCl)
Flash point:: 150 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Aqueous Acid (Sparingly), Water (Slightly, Heated)
pka: 1.94±0.10(Predicted)
form: Crystalline Powder
color: White
optical activity: [α]20/D 155°, c = 1 in 1 M HCl
Water Solubility: 0.3g/100mL
Merck: 14,7291
BRN: 2208676
LogP: -1.76 at 20℃
CAS DataBase Reference: 875-74-1(CAS DataBase Reference)
NIST Chemistry Reference: d a-Phenylglycine(875-74-1)
EPA Substance Registry System: Benzeneacetic acid, .alpha.-amino-, (.alpha.R)- (875-74-1)

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Safety

Hazard Codes: T
Risk Statements: 23/24/25-36/37/38-22-20
Safety Statements: 22-24/25-45-36/37/39-26-44-28-7-4
WGK Germany: 3
TSCA: Yes
HS Code: 29224995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P25485
Product name: D?(?)-α-Phenylglycine
Purity: 99%
Packaging: 25g
Price: $40.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: P25485
Product name: D?(?)-α-Phenylglycine
Purity: 99%
Packaging: 100g
Price: $111
Updated: 2024/03/01

TCI Chemical

Product number: P0820
Product name: D-2-Phenylglycine
Purity: >99.0%(T)
Packaging: 25g
Price: $22
Updated: 2024/03/01

TCI Chemical

Product number: P0820
Product name: D-2-Phenylglycine
Purity: >99.0%(T)
Packaging: 100g
Price: $54
Updated: 2024/03/01

Alfa Aesar

Product number: A15669
Product name: D-(-)-2-Phenylglycine, 99%
Packaging: 25g
Price: $24.65
Updated: 2024/03/01

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D-2-Phenylglycine Chemical Properties,Usage,Production

Description

L-phenylglycine (Cephalexin EP Impurity A) is a derivative of glycine, a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in the spinal cord and an allosteric modulator of NMDA receptors.

Storage

Store at room temperature. Store in cool dry place in tightly closed container. Store away from oxidizing agent.

Description

d-Phenylglycine is widely used in large quantity as the side chain that makes ampicillin and cephalexin orally acceptable.

Chemical Properties

White crystalline powder

Uses

D-(-)-2-Phenylglycine (Cefalexin EP Impurity A) is the derivative of glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Uses

D-(-)-2-Phenylglycine is the derivative of glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA r eceptors.

Definition

ChEBI: The R stereoisomer of alpha-phenylglycine.

Flammability and Explosibility

Non flammable

Synthesis

Industrially, dphenylglycine has been produced by a conventional resolution method or by kinetic resolution with acylase. Another enzymatic procedure has been developed by Yamada et al. , as shown below.

D-2-Phenylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-2-Phenylglycine chloride hydrochloride Ampicillin (2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-phenylacetic acid 1R，3R-chrysanthemic acid Potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate

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View Lastest Price from D-2-Phenylglycine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-D-Phg-OH 875-74-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1T+
Release date: 2023-09-23

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: D-2-Phenylglycine 875-74-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-03

Shanghai UCHEM Inc.

Product: D-2-Phenylglycine 875-74-1
Price: US $56.00/kg
Min. Order: 1kg
Purity: 0.98
Supply Ability: 100kg
Release date: 2024-01-10

875-74-1, D-2-PhenylglycineRelated Search:

(S)-Amlodipine Diethylstilbestrol 4-Aminophenylacetic acid Citric acid Anilinoacetic acid α-Lipoic Acid Folic acid Glycine Ethyl 2-(Chlorosulfonyl)acetate 4-Hydroxy-D-(-)-2-phenylglycine Potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate D(-)-Phenylglycinamide Methyl D-(-)-4-hydroxy-phenylglycinate Ascoric Acid 3-Hydroxy-4-Methyl-2(5H)-thiophenone (6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- 7-Amino-3-methyl-3-cephem-4-carboxylic acid 7-Amino-3-chloro cephalosporanic acid

.alpha.-amino-,(R)-Benzeneaceticacid

Benzeneacetic acid, alpha-amino-, (R)-

Benzeneaceticacid,alpha-amino-,(R)-

D-(-)-2-Phenylglycine,99%

(R)-(-)-ALPHA-AMINOPHENYLACETIC ACID FOR RESOLUTION OF RACEMATES

D(-)-alpha-Aminophenylacetic

D-a-a(1,4-cyclohexadienyl)Glyc

Benzeneacetic acid, .alpha.-amino-, (.alpha.R)-

d-(-)-à-aminophenylacetic acid

D-Phenylglycine Base

Benzeneacetic acid, alpha-amino-, (alphaR)- (9CI)

D-Phenylglycine, (R)-(-)-a-Aminophenylacetic acid

D(-)-a-Aminophenyl ycsysnar acid

D-Phenylglycine,99%e.e.

(R)-(-)-α-Aminophenylacetic acid for resolution of racemates for synthesis

PHENYLGLYCINE-D

(R)-PHENYLGLYCINE

(R)-(-)-ALPHA-AMINOPHENYLACETIC ACID

(R)-ALPHA-AMINOPHENYLACETIC ACID

(R)-(-)-ALPHA-PHENYLAMINOACETIC ACID

(R)-AMINO-PHENYL-ACETIC ACID

(R)-(-)-2-PHENYLGLYCINE

H-D-PHG-OH

H-D-(PHENYL)GLY-OH

D-(-)-PHENYLGLYCINE

D-PHENYLGLYCINE

D-(-)-2-PHENYLGLYCINE

D-2-PHENYLGLYCINE

(-)-D-ALPHA-PHENYLGLYCINE

D(-)-ALPHA-PHENYLGLYCINE

Cefaclor Impurity A (EP)

Cephalexin EP Impurity A (Ampicillin EP Impurity L)

Ampicillin Impurity 12（Ampicillin EP Impurity L）

Ampicillin EP Impurity L (Cephalexin EP Impurity A)

D-(-)-α-PhenyL

ycine

(R)-(-)-2-Phenylglycine, D-2-Phenylglycine, R(-)-α-Aminophenylacetic acid

D(-)-alpha-Phenylglycine,98%

D-(-)-α-Phenylglycine ,99%

D()-α-Phenylglycine,(R)-()-2-Phenylglycine, D-2-Phenylglycine, R-()-α-Aminophenylacetic acid

R-(-)-|á-Aminophenylacetic acid

D(-)-alpha-Phenylglycine, 98% 100GR

D(-)-alpha-Phenylglycine, 98% 25GR

(R)-(-)-A-AMINOPHENYLACETIC ACID FOR RES

(R)-2-AMino-2-phenylacetic acid

D-2-Phenylglyc

Cefalexine EP IMpurity A

Cefaclor EP IMpurity A

(2R)-AMino-2-phenylethanoic acid

Cephalexin IMpurity A (D-2-Phenylglycine)

Benzeneacetic acid, a-aMino-, (aR)-

D-(-)-alpha-Phenylglycine 99%

D-(-)-alpha-Phenylglycine, 95+%

(2R)-2-amino-2-phenylacetic acid

C-Phenylglycine

Cefalexin Impurity 1(EP Impurity A)

Cefaclor Impurity 1(Cefaclor EP Impurity A)

D-Phenylglycine≥ 99% (Assay)