2-BROMO-5-FLUORO-4-METHYLANILINE

Product Name: 2-BROMO-5-FLUORO-4-METHYLANILINE
CAS No.: 202865-78-9
Chemical Name: 2-BROMO-5-FLUORO-4-METHYLANILINE
Synonyms: 2-BROMO-5-FLUORO-4-METHYLANILINE;2-Bromo-5-fluoro-4-methylaniline98%;2-broMo-5-fluoro-4-MethylbenzenaMine;2-Bromo-5-fluoro-4-methylaniline 98%;BENZENAMINE,2-BROMO-5-FLUORO-4-METHYL;2-Bromo-5-fluoro-4-methyl-phenylamine;4-Amino-5-bromo-2-fluorotoluene, 2-Bromo-5-fluoro-p-toluidine
CBNumber: CB9413962
Molecular Formula: C7H7BrFN
Formula Weight: 204.04
MOL File: 202865-78-9.mol

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2-BROMO-5-FLUORO-4-METHYLANILINE Property

Melting point:: 39-41°C
Boiling point:: 245.3±35.0 °C(Predicted)
Density: 1.589±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.95±0.10(Predicted)
CAS DataBase Reference: 202865-78-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2921430090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B700410
Product name: 2-Bromo-5-fluoro-4-methylaniline
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC7405
Product name: 2-Bromo-5-fluoro-4-methylaniline
Purity: 98%
Packaging: 1g
Price: $35
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3730-B-25
Product name: 2-Bromo-5-fluoro-4-methylaniline
Purity: 98%
Packaging: 1g
Price: $56
Updated: 2021/12/16

Apolloscientific

Product number: PC7405
Product name: 2-Bromo-5-fluoro-4-methylaniline
Purity: 98%
Packaging: 5g
Price: $103
Updated: 2021/12/16

Matrix Scientific

Product number: 097824
Product name: 2-Bromo-5-fluoro-4-methylaniline
Purity: 95+%
Packaging: 1g
Price: $114
Updated: 2021/12/16

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2-BROMO-5-FLUORO-4-METHYLANILINE Chemical Properties,Usage,Production

Synthesis

452-77-7

202865-78-9

General procedure for the synthesis of 2-bromo-5-fluoro-4-methylaniline from 3-fluoro-4-methylaniline: Step A- Synthesis of compound 28B: Compound 28A (3-fluoro-4-methylaniline, 6.00 g, 47.9 mmol) and anhydrous potassium carbonate (6.70 g, 48.5 mmol) were dissolved in anhydrous dichloromethane (130 mL), and the mixture was cooled to -15 °C in a salt-ice bath. Subsequently, a solution of bromine (7.70 g, 48.2 mmol) in anhydrous dichloromethane (80 mL) was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was maintained at -15 °C and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of ice water (100 mL) to the reaction mixture and the aqueous layer was extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to afford the crude product compound 28B (2-bromo-5-fluoro-4-methylaniline, 11.0 g, quantitative yield), which could be used in subsequent steps without further purification.

References

[1] Patent: WO2009/32123, 2009, A2. Location in patent: Page/Page column 158
[2] Patent: WO2009/32125, 2009, A1. Location in patent: Page/Page column 98
[3] Patent: WO2009/32124, 2009, A1. Location in patent: Page/Page column 198-199
[4] Patent: WO2009/152200, 2009, A1. Location in patent: Page/Page column 65
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 3, p. 244 - 248

2-BROMO-5-FLUORO-4-METHYLANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-5-FLUORO-4-METHYLANILINE Suppliers

China 68 France 1 Germany 1 India 1 Italy 1 United Kingdom 9 United States 17 Global 98

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202865-78-9, 2-BROMO-5-FLUORO-4-METHYLANILINERelated Search:

4-BROMO-2-FLUORO-5-METHYLANILINE 97% 2-BROMO-4-FLUORO-5-METHYLANILINE,2-BROMO-4-FLUORO-5-METHYLANILINE Hydrochloride 3-Fluoro-4-methylaniline 2-Bromo-5-fluoroaniline 4-Bromofluorobenzene 5-Bromo-2-fluorotoluene 4-BROMO-5-FLUORO-2-METHYLANILINE 4-Bromo-3-fluoro-2-methylaniline 2-BROMO-5-FLUORO-4-METHYLANILINE 2,6-Dibromo-3-fluoro-4-methylaniline 5-Bromo-2-fluoro-4-nitrotoluene 2'-BROMO-5'-FLUORO-4'-METHYLACETANILIDE 2-BROMO-6-FLUORO-4-METHYLANILINE 4-BROMO-2-FLUORO-5-METHYLANILINE 2-bromo-4-fluoro-N-methylaniline 2-Bromo-4-fluoro-6-methylaniline 98%,2-Bromo-4-fluoro-6-methylaniline98%,2-BROMO-4-FLUORO-6-METHYLANILINE 5-Bromo-2-fluoro-4-methylaniline 4-bromo-2-fluoro-N-methylaniline

2-BROMO-5-FLUORO-4-METHYLANILINE

2-Bromo-5-fluoro-4-methylaniline 98%

2-broMo-5-fluoro-4-MethylbenzenaMine

4-Amino-5-bromo-2-fluorotoluene, 2-Bromo-5-fluoro-p-toluidine

2-Bromo-5-fluoro-4-methyl-phenylamine

2-Bromo-5-fluoro-4-methylaniline98%

BENZENAMINE,2-BROMO-5-FLUORO-4-METHYL

202865-78-9

Anilines, Amides & Amines

Bromine Compounds

Fluorine Compounds