Laurocapram

Chemical properties Penetration enhancer Application References

Product Name: Laurocapram
CAS No.: 59227-89-3
Chemical Name: Laurocapram
Synonyms: AZONE;azon;n-dodecylcaprolactam;n0252;tranzone;NSC11340;usafnd-72;NSC 11340;NSC-11340;USAF NO-72
CBNumber: CB9414646
Molecular Formula: C18H35NO
Formula Weight: 281.48
MOL File: 59227-89-3.mol

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Laurocapram Property

Melting point:: -7°
Boiling point:: bp50m 160°
Density: 0.906-0.926
refractive index: 1.470-1.473
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka: -0.43±0.20(Predicted)
form: Oil
color: Colourless
Merck: 14,5385
LogP: 6.570 (est)
CAS DataBase Reference: 59227-89-3(CAS DataBase Reference)
EPA Substance Registry System: Laurocapram (59227-89-3)

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Safety

Safety Statements: 24/25
RTECS: CM3995000
HS Code: 29339900
Hazardous Substances Data: 59227-89-3(Hazardous Substances Data)
Toxicity: LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: L0317
Product name: Laurocapram
Purity: >96.0%(GC)
Packaging: 5mL
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: L0317
Product name: Laurocapram
Purity: >96.0%(GC)
Packaging: 25mL
Price: $148
Updated: 2024/03/01

TRC

Product number: L185003
Product name: Laurocapram
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 090554
Product name: N-Dodecylcaprolactam
Purity: 95+%
Packaging: 1g
Price: $49
Updated: 2021/12/16

ApexBio Technology

Product number: C6524
Product name: Laurocapram
Packaging: 500mg
Price: $50
Updated: 2021/12/16

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Laurocapram Chemical Properties,Usage,Production

Chemical properties

Colorless or slightly yellow transparent liquid, insoluble in water, it can form emulsion with water, soluble in various organic solvents.

Penetration enhancer

Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.
Laurocapram on hydrophilic and lipophilic drugs have significantly transdermal Aided role. It has good aided effect on many kinds of plant extracts in emulsion state or colloidal state, and alkaloids effect is particularly evident. Transdermal penetration is stronger than dimethyl sulfoxide. 8-bromo cyclic nucleotide containing 1% azone permeability effect is equivalent to 12 times the 50% dimethyl sulfoxide. Often in combination with propylene glycol, synergy, the best use of transdermal concentration of 0.1% to 5%, safe and low toxic, non-irritating. The chemical property is stable, and it is kept up to four years at the room temperature.
It can be considered a decyl methyl sulfoxide with pyrrolidone composite for good novel penetration enhancers, skin irritation. It can promote the drug through the skin barrier corticosteroids, indomethacin, fluorouracil, hydroquinone and many other drugs transdermal absorption, improving local and systemic blood concentration, and improving the bioavailability of the drug. Lipophilic, they have transdermal effect for hydrophilic drugs. It can soften the skin and enhance its permeability. They have anti-inflammatory, analgesic and anti-itching effect. Low toxicity, oral LD50> 7g/kg, it is not compatible with strong acids or Vaseline to avoid reduce the effect.

Application

Laurocapram is used as the penetration enhancer in cosmetic preparations and personal-care products. Laurocapram is combined as an excipient (an inert substance) not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough to be active until internal use. It can be used as a topical smear, massage penetration enhancers; pesticides, as a pro-absorbing agent and sterilization plant growth regulators, pesticides pro penetration; in addition, can be used for coloring and dyeing leather and other areas of accelerator.

References

http://www.chemicalland21.com/lifescience/foco/LAUROCAPRAM.htm

Uses

antifungal lipopeptide

Uses

Laurocapram is a useful intermediate.

Uses

Pharmaceutic aid (excipient).

Laurocapram Preparation Products And Raw materials

Raw materials

Caprolactam

Preparation Products

1-Chloro-3-Phenylacetone

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Laurocapram Suppliers

Americas 1 China 496 China Hong Kong 1 Europe 4 Germany 2 India 2 Japan 2 Slovakia 1 South Korea 1 United Kingdom 6 United States 27 Global 543

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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Advantage: 62

HBCChem, Inc.

Tel: +1-510-219-6317
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Country: United States
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Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Alfa Chemistry

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Country: United States
ProdList: 24072
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

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Advantage: 58

TargetMol Chemicals Inc.

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Country: United States
ProdList: 38632
Advantage: 58

MedChemExpress

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Combi-Blocks Inc.

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TCI America

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Frontier Scientific, Inc.

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Matrix Scientific

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CarboMer, Inc.

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HBCChem Inc.

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3B Scientific Corporation

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Waterstone Technology, LLC

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AlliChem, LLC

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Riedel-de Haen AG

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Beta Pharma, Inc.

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HONEST JOY HOLDINGS LIMITED

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2A PharmaChem USA

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3B Scientific Corporation

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AK Scientific, Inc.

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APAC Pharmaceutical, LLC

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NetQem

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ChemPacific Corporation

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View Lastest Price from Laurocapram manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Laurocapram 59227-89-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-21

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Laurocapram 59227-89-3
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-08

Baoji Guokang Bio-Technology Co., Ltd.

Product: Laurocapram 59227-89-3
Price: US $46.70/KG
Min. Order: 100g
Purity: 99%
Supply Ability: 10 tons
Release date: 2021-06-07

59227-89-3, LaurocapramRelated Search:

Lauric acid Myrcene Laurocapram solution in water LAURETH-4 Lauramidopropyl betaine Sodium lauryl polyoxyethylene ether sulfate potassium dodecyl sulphate Sodium dodecyl sulfate Hexamethylenetetramine Poly(vinyl alcohol) Sodium thiosulfate pentahydrate Magnesium sulfate Ammonium lauryl sulfate MAGNESIUM LAURYL SULFATE Lauryl glucoside LDAO Lauryl betaine POLYETHYLENEGLYCOL 600 MONOOCTYL ETHER

n0252

acecloguanosine

N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone

Lauocapram

Azone, Laurocapram

DODECYLAZACYCLOHEPTAN-2-ONE

1-n-Dodecylazacycloneptan-2-one

1-Dodecylhexahydro-1H-azepine-2-one

4,5,6,7-Tetrahydro-1-dodecyl-1H-azepine-2(3H)-one

USAF NO-72

1-dodecylazepan-2-one

1-laurylazepan-2-one

hexahydro-n-lauryl-2h-azepin-2-on

1-Dodecyl-2-azepanone

DodecylcaprolactaM

1-Dodecylhexahydro-2H-Azepin-2-One (LaurocapraM)

LaurocapraM SynonyMs 1-Dodecylhexahydro-2H-azepin-2-one

Azone (oil)

n-laurylcaprolactam

tranzone

usafnd-72

AZONE

azon

LAUROCAPRAM

1-DODECYL AZACYCLOHEPTA-2-ONE

1-dodecylazacycloheptan-2-one

1-dodecylhexahydro-2h-azepin-2-one

n-dodecylcaprolactam

Laurocapra

Laurocapramum

Laurocapram Laurocapram

2H-Azepin-2-one, 1-dodecylhexahydro-

N-Dodecyl-epsilon-caprolactam

Laurocapram (water soluble)

Laurocapram USP/EP/BP

Hot Selling Laurocapram 59227-89-3 with Reasonable Price and Fast Delivery! !

NSC 11340

NSC11340

NSC-11340

Laurel azone

59227-89-3

C18H35NO

Cosmetic

Pharmaceutical intermediates, pharmaceutical raw materials

ketone

59227-89-3

bc0001

john's