Methylaminoacetaldehyde dimethyl acetal
Synthesis- Product Name
- Methylaminoacetaldehyde dimethyl acetal
- CAS No.
- 122-07-6
- Chemical Name
- Methylaminoacetaldehyde dimethyl acetal
- Synonyms
- Methylaminoacetaldeh;Methimazole USP RC A;Methimazole Impurity 1;MethylaMinoacetaldehyde;Thiamazole EP Impuriy A;Thiamazole EP Impurity A;METHYLAMINODIMETHYLACETAL;Methimazole EP Impurity A;Methylaminoacetaldehyde dime;Methimazole Related Compound A
- CBNumber
- CB9417627
- Molecular Formula
- C5H13NO2
- Formula Weight
- 119.16
- MOL File
- 122-07-6.mol
Methylaminoacetaldehyde dimethyl acetal Property
- Melting point:
- -73°C
- Boiling point:
- 140 °C (lit.)
- Density
- 0.928 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.414(lit.)
- Flash point:
- 85 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- liquid &_& neat
- pka
- 8.29±0.20(Predicted)
- color
- Colorless to Light yellow to Light orange
- PH
- 10.9 (10g/l, H2O, 20℃)
- Water Solubility
- miscible
- Sensitive
- Air Sensitive
- BRN
- 605322
- CAS DataBase Reference
- 122-07-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanamine, 2,2-dimethoxy-N-methyl-(122-07-6)
- EPA Substance Registry System
- Ethanamine, 2,2-dimethoxy-N-methyl- (122-07-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36-36/37/38
- Safety Statements
- 26-36-37/39-16
- RIDADR
- UN 1989 3/PG 3
- WGK Germany
- 3
- F
- 2-10
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29225000
- Hazardous Substances Data
- 122-07-6(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M28006
- Product name
- (Methylamino)acetaldehyde dimethyl acetal
- Purity
- 97%
- Packaging
- 25g
- Price
- $52
- Updated
- 2024/03/01
- Product number
- PHR3038
- Product name
- Methimazole Related Compound A
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 100MG
- Price
- $344
- Updated
- 2024/03/01
- Product number
- 1411016
- Product name
- Methimazole Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 3x50mg
- Price
- $1300
- Updated
- 2024/03/01
- Product number
- M0884
- Product name
- Methylaminoacetaldehyde Dimethyl Acetal
- Purity
- >98.0%(GC)(T)
- Packaging
- 25mL
- Price
- $61
- Updated
- 2024/03/01
- Product number
- M0884
- Product name
- Methylaminoacetaldehyde Dimethyl Acetal
- Purity
- >98.0%(GC)(T)
- Packaging
- 500mL
- Price
- $516
- Updated
- 2024/03/01
Methylaminoacetaldehyde dimethyl acetal Chemical Properties,Usage,Production
Synthesis
In the autoclave, add 3.00 kg of chloroacetaldehyde dimethyl acetal, 30 kg of 33% methylamine methanol solution, close the autoclave valve, heat up to 130-135 ° C, and the pressure is up to 1.2 MPa, then continue to decrease, and the reaction is incubated for 6 hours. Cool down to 25°C and press into a neutralizer. The temperature was lowered to below 10°C under stirring, 3.26 kg of 40% sodium methoxide methanol solution was added dropwise, and the temperature was kept at 0-5°C for 2-3 hours. After filtration, the filter cake was washed with methanol, and the filtrate was transferred to a distillation pot. Distill methanol at atmospheric pressure until it no longer evaporates, change it to vacuum distillation, turn on brine to condense and collect the intermediate, collect 52-60°C/24mmHg fraction, obtain 2.51kg of methylaminoacetaldehyde dimethyl acetal, GC purity 94.6 %, yield 83.1%.
Description
Methylaminoacetaldehyde dimethyl acetal can be used as a pharmaceutical synthesis intermediate, such as the preparation of methimazole, the chemical name is 1-methylimidazole-2-thiol, which is an antithyroid drug, and its mechanism of action is to inhibit thyroid endoperoxide Enzymes, thereby hindering the oxidation of iodide absorbed into the thyroid and the coupling of tyrosine, hindering the synthesis of thyroxine (T4) and triiodothyronine (T3). Animal experiments have observed that B lymphocytes synthesize antibodies, reduce the level of thyroid-stimulating antibodies in the blood circulation, and restore the suppressor T cells to normal.
Chemical Properties
clear colorless to light yellowish liquid
Uses
(Methylamino)acetaldehyde dimethyl acetal can be used as a reactant to synthesize:
- Aza[3.3.2] cyclazines by reacting with 5-methyloxazolo[3,2-a]pyridinium salts via synthesis of functionalized 5-aminoindolizines intermediates.
- N-(2,2-Dimethoxyethyl)-N-methyl-3,4-dimethoxyphenylglycine by Petasis reaction with glyoxylic acid and 3,4-dimethoxyphenylboronic acid.
- Substituted imidazoles via copper-catalyzed reaction with various nitriles.
Uses
2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,
Methylaminoacetaldehyde dimethyl acetal Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methylaminoacetaldehyde dimethyl acetal manufacturers
- Product
- Methylaminoacetaldehyde dimethyl acetal 122-07-6
- Price
- US $30.00-28.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.0% up
- Supply Ability
- 50 tons per month
- Release date
- 2022-09-26
- Product
- Methylaminoacetaldehyde dimethyl acetal 122-07-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Methylaminoacetaldehyde dimethyl acetal 122-07-6
- Price
- US $95.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2020-10-24