Methylaminoacetaldehyde dimethyl acetal

Synthesis

Product Name: Methylaminoacetaldehyde dimethyl acetal
CAS No.: 122-07-6
Chemical Name: Methylaminoacetaldehyde dimethyl acetal
Synonyms: Methylaminoacetaldeh;Methimazole USP RC A;Methimazole Impurity 1;MethylaMinoacetaldehyde;Thiamazole EP Impuriy A;Thiamazole EP Impurity A;METHYLAMINODIMETHYLACETAL;Methimazole EP Impurity A;Methylaminoacetaldehyde dime;Methimazole Related Compound A
CBNumber: CB9417627
Molecular Formula: C5H13NO2
Formula Weight: 119.16
MOL File: 122-07-6.mol

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Methylaminoacetaldehyde dimethyl acetal Property

Melting point:: -73°C
Boiling point:: 140 °C (lit.)
Density: 0.928 g/mL at 25 °C (lit.)
refractive index: n20/D 1.414(lit.)
Flash point:: 85 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: liquid &_& neat
pka: 8.29±0.20(Predicted)
color: Colorless to Light yellow to Light orange
PH: 10.9 (10g/l, H2O, 20℃)
Water Solubility: miscible
Sensitive: Air Sensitive
BRN: 605322
CAS DataBase Reference: 122-07-6(CAS DataBase Reference)
NIST Chemistry Reference: Ethanamine, 2,2-dimethoxy-N-methyl-(122-07-6)
EPA Substance Registry System: Ethanamine, 2,2-dimethoxy-N-methyl- (122-07-6)

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Safety

Hazard Codes: Xi
Risk Statements: 10-36-36/37/38
Safety Statements: 26-36-37/39-16
RIDADR: UN 1989 3/PG 3
WGK Germany: 3
F: 2-10
Hazard Note: Irritant
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29225000
Hazardous Substances Data: 122-07-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M28006
Product name: (Methylamino)acetaldehyde dimethyl acetal
Purity: 97%
Packaging: 25g
Price: $52
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3038
Product name: Methimazole Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 100MG
Price: $344
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1411016
Product name: Methimazole Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 3x50mg
Price: $1300
Updated: 2024/03/01

TCI Chemical

Product number: M0884
Product name: Methylaminoacetaldehyde Dimethyl Acetal
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $61
Updated: 2024/03/01

TCI Chemical

Product number: M0884
Product name: Methylaminoacetaldehyde Dimethyl Acetal
Purity: >98.0%(GC)(T)
Packaging: 500mL
Price: $516
Updated: 2024/03/01

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Methylaminoacetaldehyde dimethyl acetal Chemical Properties,Usage,Production

Synthesis

In the autoclave, add 3.00 kg of chloroacetaldehyde dimethyl acetal, 30 kg of 33% methylamine methanol solution, close the autoclave valve, heat up to 130-135 ° C, and the pressure is up to 1.2 MPa, then continue to decrease, and the reaction is incubated for 6 hours. Cool down to 25°C and press into a neutralizer. The temperature was lowered to below 10°C under stirring, 3.26 kg of 40% sodium methoxide methanol solution was added dropwise, and the temperature was kept at 0-5°C for 2-3 hours. After filtration, the filter cake was washed with methanol, and the filtrate was transferred to a distillation pot. Distill methanol at atmospheric pressure until it no longer evaporates, change it to vacuum distillation, turn on brine to condense and collect the intermediate, collect 52-60°C/24mmHg fraction, obtain 2.51kg of methylaminoacetaldehyde dimethyl acetal, GC purity 94.6 %, yield 83.1%.

Description

Methylaminoacetaldehyde dimethyl acetal can be used as a pharmaceutical synthesis intermediate, such as the preparation of methimazole, the chemical name is 1-methylimidazole-2-thiol, which is an antithyroid drug, and its mechanism of action is to inhibit thyroid endoperoxide Enzymes, thereby hindering the oxidation of iodide absorbed into the thyroid and the coupling of tyrosine, hindering the synthesis of thyroxine (T4) and triiodothyronine (T3). Animal experiments have observed that B lymphocytes synthesize antibodies, reduce the level of thyroid-stimulating antibodies in the blood circulation, and restore the suppressor T cells to normal.

Chemical Properties

clear colorless to light yellowish liquid

Uses

(Methylamino)acetaldehyde dimethyl acetal can be used as a reactant to synthesize:

Aza[3.3.2] cyclazines by reacting with 5-methyloxazolo[3,2-a]pyridinium salts via synthesis of functionalized 5-aminoindolizines intermediates.
N-(2,2-Dimethoxyethyl)-N-methyl-3,4-dimethoxyphenylglycine by Petasis reaction with glyoxylic acid and 3,4-dimethoxyphenylboronic acid.
Substituted imidazoles via copper-catalyzed reaction with various nitriles.

Uses

2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,

Methylaminoacetaldehyde dimethyl acetal Preparation Products And Raw materials

Raw materials

Preparation Products

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Methylaminoacetaldehyde dimethyl acetal Suppliers

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View Lastest Price from Methylaminoacetaldehyde dimethyl acetal manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd

Product: Methylaminoacetaldehyde dimethyl acetal 122-07-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98
Supply Ability: 1000
Release date: 2025-01-09

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: Methylaminoacetaldehyde dimethyl acetal 122-07-6
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methylaminoacetaldehyde dimethyl acetal 122-07-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

122-07-6, Methylaminoacetaldehyde dimethyl acetalRelated Search:

ETHANE Dimethoxymethane Chloroacetaldehyde dimethyl acetal Dimethyl sulfoxide Hexafluoroethane Emamectin 2-Aminobenzyl alcohol Bromoacetaldehyde dimethyl acetal 2-(Trifluoromethoxy)aniline 2,2-Diethoxyethylamine Acetal Dimethyl fumarate Aminoacetaldehyde dimethyl acetal 1,1-Dimethoxyethane N,N-Dimethylformamide Acetylacetaldehyde dimethyl acetal 4-Chlorobutanal dimethyl acetal Polyoxymethylene

1-METHYLAMINO-2,2-DIMETHOXYETHANE

2,2-DIMETHOXY-N-METHYLETHYLAMINE

2-(METHYLAMINO)ACETALDEHYDE DIMETHYLACETAL

1,1-DIMETHOXY-2-(METHYLAMINO)-ETHANE

(methylamino)-acetaldehyddimethylacetal

2,2-Dimethoxyethyl(methyl)amine

2,2-dimethoxy-n-methyl-ethanamin

2,2-Dimethoxy-N-methylethanamine

Acetaldehyde, (methylamino)-, dimethyl acetal

Methylamionacetaldehydediethylacetal

N-METHYLAMINOACETALDEHYDE DIMETHYL ACETAL

N-(2,2-DIMETHOXYETHYL)METHYLAMINE

METHYLAMINOACETALDEHYDE DIMETHYL ACETAL

Thiamazole EP Impurity A

Methimazole Impurity 1

Thiamazole Impurity 1（Thiamazole Impurity A)

METHYLAMINODIMETHYLACETAL

N-Methyl-2,2-dimethoxyethylamine

2-(Methylamino)acetaldehyde dimethylacetal 98%

1,1-Dimethoxy-2-methylaminoethane, 2,2-Dimethoxy-N-methylethylamine

Methyl(2,2-dimethoxyethyl)amine

N-Methyl-2,2-dimethoxyethanamine

Methylaminoacetaldehyde dimethyl acetal,97%

Ethanamine, 2,2-dimethoxy-N-methyl-

N-Methylaminoacetaldehyde dimethyl

2,2-Dimethoxy-N-methylethylamine, 1,1-Dimethoxy-2-(methylamino)ethane

Methylaminoacetaldeh

MethylaMinoacetaldehyde

N-MethylaMinoacetaldehyde-diMethylacetale

MethylaMinoacetaldehyde diMethyl acetal, 97% 100GR

(METHYLAMINO)ACETALDEHYDE DIMETHYL ACETA

(2,2-dimethoxy-ethyl)-mehyl-amine

Methimazole Related Compound A

Methylaminochloroacetaldehyde dimethyl acetal

MethylaminoacetaldehydeDimethylAcetal&gt

N- methyl acetaldehyde diethylene glycol

Methimazole USP RC A

Thiamazole EP Impuriy A

Methimazole EP Impurity A

TIANFU-CHEM 122-07-6 Methylaminoacetaldehyde dimethyl acetal

Methimazole Related Compound A (3 x 50 mg) (2,2-Dimethoxy-N-methylethanamine) (1411016)

Methylaminoacetaldehyde dime

Methimazole USP Related Compound A

Methylacetaldehyde dimethyl acetal

Methylaminoacetaldehyde dimethyl alcohol

Thiamazole EP Impurity A (Methimazole USP Related Compound A)

122-07-6

CH3NHCH2CHOCH32

AMINE

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