Description Synthesis
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Oxytetracycline dihydrate

Description Synthesis
Product Name
Oxytetracycline dihydrate
CAS No.
6153-64-6
Chemical Name
Oxytetracycline dihydrate
Synonyms
trramycin;OXYCYCLINE;DOXYCYCLINE USP 23;OXYTETRACYCLINEFEED;DOXYCYCLINE HYCHLATE;Terramycin Dihydrate;Doxycycline dihydrate;OXYTETRACYCLINE HCL BP;Oxytetracycline (200 mg);OXYTETRACYCLINE DIHYDRATE
CBNumber
CB9426658
Molecular Formula
C22H26N2O10
Formula Weight
478.45
MOL File
6153-64-6.mol
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Oxytetracycline dihydrate Property

Melting point:
181-182 °C
alpha 
-216 º (c=1,0.1 M HCl)
storage temp. 
Sealed in dry,Room Temperature
solubility 
1 M HCl: 0.1 M yellow to yellow-orange, clear
form 
crystalline
color 
yellow
Water Solubility 
slightly soluble
CAS DataBase Reference
6153-64-6(CAS DataBase Reference)
EPA Substance Registry System
Oxytetracycline dihydrate (6153-64-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
63-36-36/37/38
Safety Statements 
22-24/25-36/37/39-26-36
WGK Germany 
3
HS Code 
29413000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O4636
Product name
Oxytetracycline dihydrate
Purity
BioXtra
Packaging
10g
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
1491004
Product name
Oxytetracycline
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1537
Product name
Oxytetracycline
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
O4636
Product name
Oxytetracycline dihydrate
Purity
BioXtra
Packaging
50g
Price
$124
Updated
2024/03/01
TRC
Product number
O877501
Product name
Oxytetracycline dihydrate
Packaging
1g
Price
$120
Updated
2021/12/16
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Oxytetracycline dihydrate Chemical Properties,Usage,Production

Description

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. It's a prescription antibiotic that interferes with bacteria's ability to produce essential proteins.

Synthesis

Oxytetracycline dihydrate is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

Chemical Properties

yellow crystalline powder

Uses

Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial.

Uses

antihypertensive

brand name

Terramycin (Pfizer).

General Description

Oxytetracycline was found in the culture broth of Streptomyces rimosus by Pfizer in 1950 and named terramycin. It is closely related to chlortetracycline (aureomycin), and its structure was elucidated in 1952. Oxytetracycline has had wide clinical use as a substitute for chlortetracycline, even after the introduction of tetracycline. Oxytetracycline is administered orally, topically, and parenterally.

Purification Methods

Terramycin crystallises (as dihydrate) from water or aqueous EtOH and is soluble in MeOH, EtOH, Me2CO and H2O (0.25mg/mL at 25o ) but insoluble in Et2O and pet ether. It is amphoteric, and an aqueous solution has pH 2.0-5.0. It has max at 247, 275 and 353nm in 0.1 M phosphate (pH 4.5). [Finlay et al. Science 111 85 1951.] The hydrochloride, [2058-46-0] M 496.9 [Beilstein 14 IV 2630], crystallises from MeOH in needles and from H2O at 50o it forms plates. Terramycin has also been purified via the hydrochloride by dissolving it in H2O, adjusting to pH 6, and the solid is filtered off after 1hour. The crystals of the dihydrate are dried to constant weight in vacuum/CaCl2/25o. Drying at 60o in vacuo gives the anhydrous base m 184.5-185.5o (sintering at 180o). The dihydrate has m 181-182o. Its optical rotation in MeOH decreases from [] D 25 +26o (c 0.5%) to [] D 25 +11.3o after standing for 16hours. It forms a sodium salt and a CaCl2 complex. [Regna et al. J Am Chem Soc 73 4211 1951, Beilstein 14 IV 2633.]

Oxytetracycline dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Oxytetracycline dihydrate manufacturers

Dideu Industries Group Limited
Product
Oxytetracycline dihydrate 6153-64-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Oxytetracycline dihydrate 6153-64-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Oxytetracycline dihydrate 6153-64-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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