2'-Hydroxypropiophenone
- Product Name
- 2'-Hydroxypropiophenone
- CAS No.
- 610-99-1
- Chemical Name
- 2'-Hydroxypropiophenone
- Synonyms
- 2-Propionylphenol;o-Propiophenol;2'-hydroxy acetone;o-Hydroxylpropioph;2'-Hydroxypropiophen;2-HYDROXYNITROBENZENE;O-HYDROXYPROPIOPHENONE;2-HYDROXYPROPIOPHENONE;o-Hydroxylpropiophenone;2'-hydroxyphenylacetone
- CBNumber
- CB5717338
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 610-99-1.mol
2'-Hydroxypropiophenone Property
- Melting point:
- 20-22 °C
- Boiling point:
- 115 °C15 mm Hg(lit.)
- Density
- 1.094 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.548(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- 8.33±0.35(Predicted)
- color
- Colourless
- BRN
- 1860264
- InChI
- 1S/C9H10O2/c1-2-8(10)7-5-3-4-6-9(7)11/h3-6,11H,2H2,1H3
- InChIKey
- KDUWXMIHHIVXER-UHFFFAOYSA-N
- SMILES
- CCC(=O)c1ccccc1O
- LogP
- 2.540
- CAS DataBase Reference
- 610-99-1(CAS DataBase Reference)
- NIST Chemistry Reference
- ortho-Hydroxypropiophenone(610-99-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H55103
- Product name
- 2′-Hydroxypropiophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $45.01
- Updated
- 2025/07/31
- Product number
- H0298
- Product name
- 2'-Hydroxypropiophenone
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- H996363
- Product name
- 2''-Hydroxypropiophenone
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0021063
- Product name
- 2'-HYDROXY PROPIOPHENONE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1129.92
- Updated
- 2021/12/16
- Product number
- CHM0021063
- Product name
- 2'-HYDROXY PROPIOPHENONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $815.93
- Updated
- 2021/12/16
2'-Hydroxypropiophenone Chemical Properties,Usage,Production
Chemical Properties
CLEAR BROWNISH LIQUID
Definition
ChEBI: 2'-hydroxypropiophenone is an aromatic ketone.
Preparation
Obtained by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide , then at 130–150° for 2–3 h after solvent elimination (32–35%)
with aluminium chloride in chlorobenzene using microwave irradiation for 3 min at 106° (28%)
with aluminium chloride in nitrobenzene at 50° for 18 h (16%) or at 20° for 48 h (10%)
with aluminium chloride in nitromethane at 20° for 7 days (20%)
with aluminium chloride in heptane at 80–90° for 7 h (53%) or in tetrachlo- roethane at 95° for 5 h (43%)
with aluminium chloride without solvent at 250° for 5 min or at 180–200° for 15 min (76–78%), at 140–160° (32–35%), at 140°
with zirconium chloride in o-dichlorobenzene at 120° for 3 h (83%)
with titanium tetrachloride in o-dichlorobenzene at 150° for 1 h (62%) , in nitromethane at 20° for 7 days (13%) or without solvent at 50° for 10 h (30%)
with titanium tetrabromide in o-dichlorobenzene at 150° for 1 h (60%)
with stannic chloride at 50° for 3 h (25%)
with boron trifluoride at 120–135° for 15 min (15%)
with zinc chloride at 180–200° for 15 min (10%)
with polyphosphoric acid at 100° (13%)
Also obtained by Friedel–Crafts acylation of phenol with propionyl chloride in the presence of aluminium chloride (40%), at 120–130° for 1 h (45%) according to the method
Also obtained by acylation of phenol with propionic acid
in the presence of boron trifluoride at 165° for 1 h (45%) or at 80° for 2 h (8%)
in the presence of polyphosphoric acid at 100° for 10 min (by-product)
in the presence of zinc chloride at 160° for 1 h
Also obtained by isomerization of 4-hydroxypropiophenone with aluminium chloride (1.5 equiv) at 165° for 1 h (40%) or at 180–200° for 15 min (55%)
Also obtained by demethylation of 2-propionylanisole with fuming hydrochloric acid (d = 1.19) in a sealed tube at 110° for 6 h
Also obtained (by-product) by heating 3-tert-butyl-4-hydroxypropiophenone with aluminium chloride at 170° for 15 min (13%)
Also obtained by treatment of 2,3-dimethylchromone with sodium ethoxide in boiling ethanol for 30 h according to the method
Also obtained from 2-allylphenol by treatment with perbenzoic acid in ethyl ether, first at 0°, then between 0° and 25° for 24 h (78%)
Also obtained by reaction of 2-bromophenyl propionate in a ethyl ether/hexane/THF mixture at low temperature (78 to 95°) with sec-butyllithium to give, after hydrolysis, the titled ketone (metal-promoted Fries rearrangement) (17%)
Also obtained by reaction of ethylmagnesium bromide
with 2-hydroxybenzamide in boiling benzene, followed by hydrolysis (30%)
with 2-hydroxy-N,N-diethylbenzamide in boiling benzene, followed by hydrolysis (82–84%)
Also isolated by heating of 1-(o-hydroxyphenyl)cyclopropyltrimethylam-monium iodide for 1 h at 140° with 1.5 equiv of N,N-diisopropylethylamine (not water-free) (38%)
Also obtained by hydrolysis of 2-(1-methyliminopropyl)phenol (4aa) with aqueous acetic acid/THF at 40° for 4 h (86%)
Also obtained by photolysis of phenyl propionate in water or in solution containing b-cyclodextrine (254 nm) at 25° for 2 h
Also obtained by treatment of 2-(1-hydroxypropyl)phenol with MnO2 in methylene chloride for 7 h at r.t.
2'-Hydroxypropiophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2'-Hydroxypropiophenone Suppliers
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View Lastest Price from 2'-Hydroxypropiophenone manufacturers
- Product
- 2'-Hydroxypropiophenone 610-99-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-11-18
- Product
- 2-Propionylphenol 610-99-1
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.01KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-21
- Product
- 2'-Hydroxypropiophenone 610-99-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-13